Close menu
Science Library Category:

Vaccine - Vaccination; Immunize - Immunization

Multiple Vaccinations and the Enigma of Vaccine Injury
Published: 2020
SYNOPSIS

The increasing rates of allergy, ear infections, and neurodevelopmental disorders (NDDs) in countries with high rates of vaccination could be related to mass vaccination and to its impact on liver function and vitamin A metabolism.

CITATION

Mawson, A.R.; Croft, A.M. Multiple Vaccinations and the Enigma of Vaccine Injury. Vaccines 2020, 8, 676.

SUMMARY

Mawson and Croft have written a comprehensive review article in the journal Vaccines and have investigated the role of multiple vaccinations in long term health effects include neurodevelopmental disorders, allergies, infections and neuropsychiatric disorders.  Past research on vaccine adverse events highlighted in the paper includes multiple childhood vaccines as well as multiple vaccines given to military personnel during the Gulf war.   Mawson and Croft hypothesize that multiple vaccines trigger the retinoid cascade which initiates apoptotic hepatitis that releases stored vitamin A compounds into circulation in toxic concentrations.  Further, the authors link vitamin A toxicity to multiple adverse events following vaccination.

This review article is a very important contribution to the science around vaccine injury, especially injuries following multiple vaccinations which given the bloated CDC infant vaccination schedule is the rule and not the exception.  Mawson has previously completed his own study of vaccinated versus unvaccinated children where he found relationships between vaccination status and multiple sequelae including allergic rhinitis, eczema, otitis media, pneumonia and neurodevelopmental disorders (Mawson et al. 2017, J Transl Sci).

View Abstract

Impact of catch-up vaccination on aluminum exposure due to new laws and post social distancing
Published: 2020
SYNOPSIS

Delay or catch-up vaccination due to COVID19 social distancing should be done judiciously if at all, to minimize aluminum toxicity.

CITATION

Lyons-Weiler, J. G McFarland and E La Joie. 2020. Impact of catch-up vaccination on aluminum exposure due to new laws and post social distancing; Journal of Trace Elements in Medicine and Biology Volume 62, December 2020, 126649 http://sciencedirect.com/science/article/pii/S0946672X20302145

SUMMARY

This study utilized the established clearance and accumulation models to calculate expected per-body-weight whole-body toxicity of aluminum from vaccines considering for children of all ages under CDC’s Catch-Up schedule from birth to ten years, assuming social distancing for 6 months. Our updated Pediatric Dose Limit (PDL) model assumes a linear improvement in renal function from birth to two years. The results indicate that due diligence in considering alternative spacing and use of non-aluminum containing vaccines when possible will reduce whole body toxicity and may reduce risk of morbidity associated with exposure to aluminum. The study concludes that careful consideration of expected aluminum exposures during regular and Catch-Up vaccination is found to be especially important for infants and children below 2 years of age.  We urge caution in the mass re-starting of vaccination under CDC’s Catch-Up schedule for children under 12 months and offer alternative strategies to minimize per-day/week/month exposure to aluminum hydroxide following the COVID-19 period of isolation.

View Abstract

HPV vaccination discourses and the construction of “at-risk” girls
Published: 2020
SYNOPSIS

Peer-reviewed critique of Merck’s reckless and immoral marketing strategy for Gardasil.

CITATION

Geneviève Rail,  Luisa Molino, Caroline Fusco, Moss Edward Norman,  LeAnne Petherick,  Jessica Polzer, Fiona Moola,  Mary Bryson. June 2018; Canadian Journal of Public Health (2018) 109:622–632 https://doi.org/10.17269/s41997-018-0108-8.

SUMMARY

The objective of this study was to investigate the deployment of HPV vaccination (HPVV) discourses and their impact on Canadian girls, parents, nurses and physicians.

View Abstract

Acute exposure and chronic retention of aluminum in three vaccine schedules and effects of genetic and environmental variation
Published: 2020
SYNOPSIS

The CDC vaccine schedule results in a high degree of chronic aluminum toxicity in the first seven months of life.

CITATION

McFarland G, La Joie E, Thomas P, Lyons-Weiler J. Journal of Trace Elements in Medicine and Biology. 2019 Dec 5;58:126444.

SUMMARY

This study shows that the CDC vaccine schedule results in a high degree of chronic aluminum toxicity in the first seven months of life—a time period critically important to neurodevelopment and immune system development. The authors reached this conclusion after assessing “time spent in toxicity” (defined as “the percentage of days of each week an infant spends with a body burden that exceeds the minimum safe level”) for the CDC schedule and two other lower-aluminum schedules. Important safety considerations include aluminum adjuvant dose per vaccine, spacing of aluminum-containing vaccines, the child’s weight at the time of vaccination and genetic variants that may limit ability to clear aluminum. Changes to the vaccine schedule, including use of vaccines that do not contain aluminum, can significantly reduce “time spent in toxicity.”

View Abstract

Continuing rotavirus circulation in children and adults despite high coverage rotavirus vaccination in Finland.
Published: 2019
SYNOPSIS

Pre-exanthem transmission of measles from airport staff to HCWs with secondary vaccine failure poses a grave challenge to hospital infection control.

CITATION

Markkula J, Hemming-Harlo M, Savolainen-Kopra C, Al-Hello H, Vesikari T. Journal of Infectious Medicine. 2019 Sep 30. pii: S0163-4453(19)30280-4. doi: 10.1016/j.jinf.2019.09.009.

SUMMARY

Despite good herd immunity with overall seroprevalence of >95% against measles, major outbreaks of measles occurred among HKIA staff having daily contact with many international pssengers. Lessons from severe acute respiratory syndrome (SARS) and measles outbreaks suggested that an airport can be a strategic epidemic center. Pre-exanthem transmission of measles from airport staff to HCWs with secondary vaccine failure poses a grave challenge to hospital infection control.

View Abstract

Vaccination with bovine, chick, yeast antigens synthesizes cross-reactive antibodies targeting human acetylcholine receptor and MuSK protein to cause Myasthenia Gravis: Confirmed by natural experiment (VAERS data), bioinformatics, case reports, animal experiments and titer study
Published: 2019
SYNOPSIS

Animal protein containing vaccines cause autoimmune diseases even when
the vaccine does not contain an adjuvant. Adjuvanted vaccines only make the problem worse.
Vaccines interact to cause autoimmune diseases.

CITATION

Arumugham, Vinu. Zenodo, 2019, September 16 http://doi.org/10.5281/zenodo.3421559.

SUMMARY

Myasthenia Gravis (MG) is a neuromuscular junction disorder, development of which is often reported following the administration of many vaccines. Most cases occur following administration of the influenza vaccines (per the Vaccine Adverse Event Reporting System-VAERS), most of which are manufactured using embryonated chicken eggs and contain residual egg proteins (AchR proteins). The chick proteins are very similar to the AchR proteins in human beings, so when the antibody production is directed against the chick protein there is a cross reaction with the human AchR, causing MG.

A similar mechanism is involved in Graves’ disease (GD). Yeast (Saccharomyces cerevisiae) is used to produce recombinant Hepatitis B vaccine (HBV), Human Papillomavirus vaccine (HPV) and injectable insulin products. We show significant protein sequence homology between GD autoepitopes, animal proteins and S. cerevisiae proteins. Humoral immune response directed against S. cerevisiae occurs following HBV, HPV administration and prolonged injectable insulin usage as in type 1 diabetes. Thus leading to the development of GD and numerous other autoimmune disorders.

The findings described add to the evidence that non-target antigens (NTA) in vaccines cause numerous disorders.

View Abstract

Primary vaccine failure to routine vaccines: Why and what to do?
Published: 2019
SYNOPSIS

About 2%–10% of healthy individuals fail to mount antibody levels to routine vaccines.

CITATION

Wiedermann U, Garner-Spitzer E, Wagner A. Human Vaccines & Immunotherapeutics. 2016;12(1):239–243.

SUMMARY

Two sets of factors are responsible for vaccine failure: vaccine-related factors (e.g., failures in vaccine attenuation, vaccination regimes or administration) and host-related factors (e.g., genetics, immune status, age, health or nutritional status). Primary vaccine failure describes the inability to respond to primary vaccination, and secondary vaccine failure is characterized by a loss of protection after initial effectiveness. Studies indicate that about 2%–10% of healthy individuals fail to mount antibody levels to routine vaccines. T-regulatory as well as B-regulatory cells and the production of IL-10 are involved in non/hypo-responsiveness to vaccination. Non-responsiveness increases with age, indicating that vaccine schedules and doses (at least for primary vaccination) should be adapted according to age. Studies also suggest that different vaccination approaches may be needed for allergic or obese individuals. The significant paradigm shift taking place in many fields of medical research and care should extend the concept of personalized medicine into the field of vaccinology.

View Abstract

The 112-Year Odyssey of Pertussis and Pertussis Vaccines—Mistakes Made and Implications for the Future
Published: 2019
SYNOPSIS

Because of linked-epitope suppression, all children who were primed by DTaP vaccines will be more susceptible to pertussis throughout their lifetimes, and there is no easy way to decrease this increased lifetime susceptibility.

CITATION

Cherry, James D. , Journal of the Pediatric Infectious Diseases Society, piz005, 2019 Feb 22.

SUMMARY

In the last 13 years, major pertussis epidemics have occurred in the United States, and numerous studies have shown the deficiencies of DTaP vaccines, including the small number of antigens that the vaccines contain and the type of cellular immune response that they elicit. The type of cellular response a predominantly, T2 response results in less efficacy and shorter duration of protection. Because of the small number of antigens (3–5 in DTaP vaccines vs >3000 in DTwP vaccines), linked-epitope suppression occurs. Because of linked-epitope suppression, all children who were primed by DTaP vaccines will be more susceptible to pertussis throughout their lifetimes, and there is no easy way to decrease this increased lifetime susceptibility.

View Abstract

Reconsideration of the immunotherapeutic pediatric safe dose levels of aluminum
Published: 2018
SYNOPSIS

The levels of aluminum present in individual vaccines and in the modern vaccine schedule as a whole are problematically high.

Citation

Lyons-Weiler J, Ricketson R. Reconsideration of the immunotherapeutic pediatric safe dose levels of aluminum. Journal of Trace Elements in Medicine and Biology. 2018;48:67-73.

Summary

The authors show that current levels of aluminum in vaccines derive from “outdated information, unwarranted assumptions and errors.” Whereas aluminum dosing in vaccines should be expressed in terms of micrograms per kilogram of body weight per day, the Food and Drug Administration (FDA) references aluminum amounts in terms of micrograms per dose. As a result, aluminum amounts do not appropriately adjust for toxicological differences between adults and children, males and females or normal-birthweight versus low-birthweight infants. The FDA also ignores dose-related toxicity and body burden despite routine administration of multiple aluminum-containing vaccines at a single health care visit. The levels of aluminum currently present in individual vaccines and in the modern vaccine schedule as a whole are “problematically high.”

View Abstract

Vaccines and neuroinflammation
Published: 2018
SYNOPSIS

Vaccination can trigger a series of cascading events that disturbs the balance between “protective immunity” and “destructive inflammation.”

Citation

Giannotta G, Giannotta N. International Journal of Public Health & Safety. 2018;3:3.

 

Summary

This study explores molecular mechanisms capable of explaining “post-vaccination inflammatory syndrome” and the neuroinflammation observed in children with autism. Focusing especially on vaccines (such as HPV vaccines) that contain biopersistent aluminum adjuvants, the authors describe how “continuously escalating doses of this poorly biodegradable adjuvant…may become insidiously unsafe,” especially in children who are vaccinated repeatedly or who have an immature or altered blood-brain barrier. Vaccination can trigger a series of cascading events (involving overexpression of the signaling molecules that regulate inflammation and activation of brain cells called microglia) that disturbs the balance between “protective immunity” and “destructive inflammation.”

View Abstract

Sponsorship bias in base-case values and uncertainty bounds of health economic evaluations? A systematic review of herpes zoster vaccination
Published: 2018
SYNOPSIS

Economic evaluations of vaccination programs may be biased when they are industry-funded.

Citation

Bilcke J, Verelst F, Beutels P. Sponsorship bias in base-case values and uncertainty bounds of health economic evaluations? A systematic review of herpes zoster vaccination. Medical Decision Making. 2018;38(6):730-745.

 

Summary

This study suggests that economic evaluations of vaccination programs have the potential to be biased when they are industry-funded. Industry-funded studies of shingles vaccination have reported more favorable cost-effectiveness ratios than non-industry funded studies. The authors caution researchers and decision-makers to be “aware of potential sponsorship bias” and also warn against cherry-picking, stating that evaluations “should consider all relevant data sources rather than (subjectively) selecting a subset of the available evidence.” In addition, they emphasize the importance of a “complete picture of the available evidence and uncertainty” when evaluating indicators such as disease burden and case fatality rate.

View Abstract

Cancer immunology, bioinformatics and chemokine evidence link vaccines contaminated with animal proteins to autoimmune disease: a detailed look at Crohn’s disease and Vitiligo
Published: 2018
SYNOPSIS

The contamination of vaccines with animal proteins that resemble human proteins can trigger autoimmunity.

Citation

Arumugham V, Trushin MV.  Journal of Pharmaceutical Sciences and Research. 2018;10(8):2106-2110.

Summary

Vaccines are contaminated with animal proteins that resemble human proteins, and this can result in autoimmunity. This study, which used bioinformatics to analyze animal proteins in vaccines and their similarity to human proteins, adds to growing evidence of vaccines inducing autoimmune diseases such as type 1 diabetes, Crohn’s disease, vitiligo, systemic lupus erythematosus and rheumatoid arthritis. The authors suggest that the live viruses and aluminum adjuvants in certain vaccines can stimulate the activation of particular T cells that, upon activation, may cause autoimmune disease. Because autoimmune reactions vary from person to person, “not everyone will develop overt disease”; thus, autoimmune illness may represent the tip of a broader “iceberg” of subclinical effects.

View Abstract

Post-licensure safety surveillance study of routine use of quadrivalent meningococcal diphtheria toxoid conjugate vaccine
Published: 2017
SYNOPSIS

Adolescents given meningococcal vaccines have experienced a wide variety of serious adverse events, including new autoimmune conditions and death.

CITATION

Hansen J, Zhang L, Klein NP, et al. Vaccine 2017;35(49 Pt B):6879-84.

 

SUMMARY

Adolescents receiving the Menactra® meningococcal vaccine (MenACWY-D) in 2005-2006 experienced a variety of adverse events in the six months following vaccination—including death—but the researchers (one of whom was affilated with the vaccine’s manufacturer, Sanofi Pasteur) concluded that only two diagnoses (diabetes and juvenile rheumatoid arthritis) were “possibly related to vaccination.” After comparing 31,000 Kaiser Permanente patients who received the MenACWY-D vaccine to 31,000 matched teens who had received a tetanus-diphtheria (Td) or hepatitis vaccine the previous year, the researchers assessed 1660 outcomes and determined that 1.3% were “significantly elevated” in the meningococcal group. There were two deaths in vaccinees with cancer (“with onset preceding vaccination”) following MenACWY-D vaccination as well as a third cardiac-related death; there was also one fetal death in a young woman who received Menactra® during pregnancy. Many of the adverse events, including difficulty breathing, occurred two or more months following vaccination.

View Abstract

Advanced Clinical Decision Support for Vaccine Adverse Event Detection and Reporting
Published: 2015
SYNOPSIS

The odds of a VAERS report submission during the implementation period were 30.2 times greater than the odds during the comparable preimplementation period when an open-source, electronic health record–based clinical decision support system is used.

CITATION
SUMMARY

Reporting of adverse events (AEs) following vaccination can help identify rare or unexpected complications of immunizations and aid in characterizing potential vaccine safety signals. We developed an open-source, generalizable clinical decision support system called Electronic Support for Public Health–Vaccine Adverse Event Reporting System (ESP-VAERS) to assist clinicians with AE detection and reporting.

In the 8 months following implementation, 91 622 vaccinations were given. ESP-VAERS sent 1385 messages to responsible clinicians describing potential AEs. Clinicians opened 1304 (94.2%) messages, responded to 209 (15.1%), and confirmed 16 for transmission to VAERS. An additional 16 high-probability AEs were sent automatically. Reported events included seizure, pleural effusion, and lymphocytopenia. The odds of a VAERS report submission during the implementation period were 30.2 (95% confidence interval, 9.52–95.5) times greater than the odds during the comparable preimplementation period.

View Abstract

Can awareness of medical pathophysiology in autism lead to primary care autism prevention strategies?
Published: 2013
SYNOPSIS

Following implementation of changes in a pediatric medical practice to address autism risks, no new cases of autism occurred.

Citation

Mumper E. North American Journal of Medicine and Science. 2013;6:134-144.

 

Summary

In 2005, the author’s pediatric practice implemented seven changes to address autism risks, focusing on minimizing environmental toxicant exposure, encouraging prolonged breastfeeding, recommending probiotics, providing nutritional counseling, limiting use of antibiotics and acetaminophen and allowing a modified vaccine schedule. No new cases of autism occurred in children born between 2005 and 2011, even though the CDC autism rate would have predicted about six new cases in the practice over that period. The author cautions that “epidemiology may be too blunt a tool to determine all risks for subsets of the population who may be more vulnerable to vaccine reactions.”

View Abstract

Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010
Published: 2012
SYNOPSIS

Infants who received more vaccines had much higher hospitalization and death rates than infants who received fewer vaccines.

CITATION

GS Goldman, NZ Miller. Human and Experimental Toxicology, 2012, 31(10) 1012–1021.

SUMMARY

“The hospitalization rate increased linearly from 11.0% (107 of 969) for 2 doses to 23.5% (661 of 2817) for 8 doses and decreased linearly from 20.1% (154 of 765) for children aged < 0.1 year to 10.7% (86 of 801) for children aged 0.9 year. Our findings show a positive correlation between the number of vaccine doses administered and the percentage of hospitalizations and deaths. Since vaccines are given to millions of infants annually, it is imperative that health authorities have scientific data from synergistic toxicity studies on all combinations of vaccines that infants might receive. Finding ways to increase vaccine safety should be the highest priority."

View Abstract

Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?
Published: 2011
SYNOPSIS

Canadian researchers report vaccine aluminum and autism prevalence related.

CITATION

Tomljenovic L, Shaw CA. Journal of Inorganic Biochemistry. 2011;105:1489-1499.

SUMMARY

“Dysfunctional immunity and impaired brain function are core deficits in ASD. Aluminum (Al), the most commonly used vaccine adjuvant, is a demonstrated neurotoxin and a strong immune stimulator. Hence, adjuvant Al has the potential to induce neuroimmune disorders. The application of the Hill’s criteria to these data indicates that the correlation between Al in vaccines and ASD may be causal. Because children represent a fraction of the population most at risk for complications following exposure to Al, a more rigorous evaluation of Al adjuvant safety seems warranted. By satisfying eight of the Hill’s criteria for establishing causality applicable to our study, we show that Al-adjuvanted vaccines may be a significant etiological factor in the rising prevalence of ASD in the Western world. We also show that children from countries with the highest ASD prevalence appear to have a much higher exposure to Al from vaccines, particularly at 2 months of age.”

View Abstract

Interindividual variations in the efficacy and toxicity of vaccines
Published: 2010
SYNOPSIS

Researchers warn of sizable difference in individual reaction to vaccines, stress need to avoid increasing side effects of vaccines.

CITATION

Chandan Thomasa, Majid Moridanib. Toxicology 278, 2010 204-210.

SUMMARY

“A number of currently available vaccines have shown significant differences in the magnitude of immune responses and toxicity in individuals undergoing vaccination. A number of factors may be involved in the variations in immune responses, which include age, gender, race, amount and quality of the antigen, the dose administered and to some extent the route of administration, and genetics of immune system. Hence, it becomes imperative that researchers have tools such as genomics and proteomics at their disposal to predict which set of population is more likely to be non-responsive or develop toxicity to vaccines.. With the increasing number of side effects associated with a number of vaccines reported over the years, it has become imperative to develop new technologies that can effectively assist in the development and evaluation of vaccines for efficacy and toxicity.”

View Abstract

Delayed acquisition of neonatal reflexes in newborn primates receiving a thimerosal-containing Hepatitis B vaccine: Influence of gestational age and birth weight
Published: 2009
SYNOPSIS

Newborn monkeys given a mercury-containing hepatitis b vaccine had significant delays in neonatal reflexes and neurological development.

CITATION

Laura Hewitson, Lisa A. Houser, Carol Stott, Gene Sackett, Jaime L. Tomko, David Atwood, Lisa Blue, E. Railey White, Andrew J. Wakefield. NeuroToxicology, 2009; doi:10.1016/j.neuro.2009.09.008.

SUMMARY

“In summary, this study provides preliminary evidence of abnormal early neurodevelopmental responses in male infant rhesus macaques receiving a single dose of Th-containing HB vaccine at birth and indicates that further investigation is merited.”

View Abstract

Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction
Published: 2009
SYNOPSIS

French scientists report aluminum from vaccines causes chronic cognitive dysfunction.

CITATION

Maryline Couette, Marie-Françoise Boisse, Patrick Maison, Pierre Brugieres, Pierre Cesaro, Xavier Chevalier, Romain K. Gherardi, Anne-Catherine Bachoud-Levi, François-Jérôme Authier. Journal of Inorganic Biochemistry, 2009.

SUMMARY

“In conclusion, long-term persistence of vaccine-derived aluminum hydroxide within the body assessed by MMF is associated with cognitive dysfunction, not solely due to chronic pain, fatigue and depression. In conclusion, this work is the first firm demonstration that cognitive dysfunction is a central feature in MMF, this dysfunction being much more frequent and severe than suspected by routine neurological evaluation. Instead of being a non-specific bystander effect of pain, fatigue or depression, MACD seems to reflect an underlying organic, inflammatory or toxic, brain involvement.”

View Abstract

Evaluation of non-specific effects of infant immunization on early infant mortality in southern Indian population.
Published: 2005
SYNOPSIS

Among girls, those who received both BCG and DTP experienced higher mortality than those who received only one of the two vaccines (hazards ratio 2.4; 95% confidence interval 1.2-5.0).

CITATION

Moulton LH, Rahmathullah L, Halsey NA, Thulasiraj RD, Katz J, Tielsch JM. Tropical Medicine and International Health, 2005 Oct;10(10):947-55.

SUMMARY

In a study of children under 2 years of age in Guinea-Bissau, Kristensen et al. (2000) found immunization with Bacille Calmette Guerin (BCG) vaccine to be associated with lower mortality, but stated that oral polio vaccine (OPV) and diphtheria, tetanus, polio (DTP) vaccines were associated with higher mortality. More recently, it has been suggested that this effect may be gender-specific, existing primarily among girls. This evaluation, focused on relating timing of BCG and DTP vaccine receipt to mortality from 1 week to 6 months of age, with emphasis on gender differentials found that girls that received both BCG and DTP experienced higher mortality than those who received only one of the two vaccines.

View Abstract

Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism
Published: 2002
SYNOPSIS

Utah state scientists find autoimmune reaction to MMR in children with autism, including autoimmunity to myelin basic protein, a brain building-block.

CITATION

Singh VK, Lin SX, Newell E, Nelson C. Journal of Biomedical Science. 2002;9:359–364.

SUMMARY

“[A]s described herein, autistic children showed a serological correlation between MMR and brain autoimmunity, i.e., over 90% of MMR antibody-positive autistic sera also had autoantibodies to brain MBP. This is quite an intriguing observation in favor of a connection between atypical measles infection and autism; an atypical infection usually refers to infection that occurs in the absence of a rash. An atypical measles infection in the absence of a rash and unusual neurological symptoms was recently described to suggest the existence of a variant MV in children and adults. In light of these new findings, we suggest that a considerable proportion of autistic cases may result from an atypical measles infection that does not produce a rash but causes neurological symptoms in some children. The source of this virus could be a variant MV or it could be the MMR vaccine.”

Macrophagic myofasciitis lesions assess long-term persistence of vaccine derived aluminum hydroxide in muscle
Published: 2001
SYNOPSIS

French scientists tie aluminum adjuvant in vaccine to macrophagic myofasciitis.

CITATION

R.K. Gherardi, M. Coquet, P. Cherin, L. Belec, P. Moretto, P.A. Dreyfus. Brain, 2001, 124, 1821-1831.

SUMMARY

“Macrophagic myofasciitis (MMF) is an emerging condition of unknown cause, detected in patients with diffuse arthromyalgias and fatigue, and characterized by muscle infiltration by granular periodic acid-Schiff’s reagent-positive macrophages and lymphocytes. Intracytoplasmic inclusions have been observed in macrophages of some patients. To assess their significance, electron microscopy was performed in 40 consecutive cases and chemical analysis was done by microanalysis and atomic absorption spectrometry. Inclusions were constantly detected and corresponded to aluminium hydroxide, an immunostimulatory compound frequently used as a vaccine adjuvant.”

View Abstract

Annual Summary of Vital Statistics: Trends in the Health of Americans During the 20th Century
Published: 2000
SYNOPSIS

CDC scientists admit that 90% of infectious disease mortality decrease in the United States happened before vaccines were available.

CITATION

Bernard Guyer, MD, Mary Anne Freeman, MA, Donna M. Strobino, PhD, Edward J. Sondik, PhD. Pediatrics, Dec 2000, Vol. 106, No. 6.

SUMMARY

“Thus vaccination does not account for the impressive declines in mortality seen in the first half of the century…nearly 90% of the decline in infectious disease mortality among US children occurred before 1940, when few antibiotics or vaccines were available.”

View Abstract

Effects of Diphtheria-Tetanus-Pertussis or Tetanus Vaccination on Allergies and Allergy-Related Respiratory Symptoms Among Children and Adolescents in the United States
Published: 2000
SYNOPSIS

UCLA researchers find the DTP vaccine is causing asthma.

CITATION

Eric L. Hurwitz, DC, PhD, and Hal Morgenstern, PhD. Journal of Manipulative and Physiological Therapeutics, Volume 23, Number 2, February 2000.

SUMMARY

“Asthma and other allergic hypersensitivity reactions and related symptoms may be caused, in part, by the delayed effects of DTP or tetanus vaccination. Because the proportion of US children who have received at least 1 dose of DTP vaccine approaches 100%, the number of allergies and allergy-related conditions attributable to DTP or tetanus vaccination in the United States may be very high. For example, assuming that the estimated vaccination effect is unbiased, 50% of diagnosed asthma cases (2.93 million) in US children and adolescents would be prevented if the DTP or tetanus vaccination was not administered.”

View Abstract

The timing of pediatric immunizations and the risk of Insulin-Dependent diabetes mellitus
Published: 1997
SYNOPSIS

Addition of the Hepatitis B Vaccine in 1988 Increased the Rate of Type 1 Diabetes 1.62X in Children in New Zealand. The incidence of type I diabetes in person 0-19 years old living in Christchurch rose from 11.2 cases per 100,000 children annually in the years before the immunization program, 1982-1987, to 18.1 cases per 100,000 children annually ( P = .0008) in the years following the immunization, 1989-1991.

CITATION

Classen David C.; Classen, John Barthelow; Infectious Diseases in Clinical Practice: September-October 1997 – Volume 6 – Issue 7 – ppg 449-454.

SUMMARY

Insulin-dependent diabetes mellitus (IDDM) is believed to be an autoimmune disease induced by a variety of environmental stimuli. Vaccines and infectious agents have been suggested to have an influence, but most of this research has been centered on the ability of these agents to infect the pancreatic islet cells or contain antigens that mimic autoantigens. Classen found that administration of the diphtheria-tetanus-pertussis (DTP) and anthrax vaccines to mice and rats at birth prevented the development of diabetes, whereas administration of the DTP vaccine starting at 8 weeks was associated with an increased incidence of diabetes.

View Abstract