Science Library Category:

Vaccines

Published: 2013
SYNOPSIS

Following implementation of changes in a pediatric medical practice to address autism risks, no new cases of autism occurred.

TITLE

Can awareness of medical pathophysiology in autism lead to primary care autism prevention strategies?

Citation

Mumper E. North American Journal of Medicine and Science. 2013;6:134-144.

 

Summary

In 2005, the author’s pediatric practice implemented seven changes to address autism risks, focusing on minimizing environmental toxicant exposure, encouraging prolonged breastfeeding, recommending probiotics, providing nutritional counseling, limiting use of antibiotics and acetaminophen and allowing a modified vaccine schedule. No new cases of autism occurred in children born between 2005 and 2011, even though the CDC autism rate would have predicted about six new cases in the practice over that period. The author cautions that “epidemiology may be too blunt a tool to determine all risks for subsets of the population who may be more vulnerable to vaccine reactions.”

View Abstract

TAGS
Published: 2013
SYNOPSIS

Canadian researchers: aluminum in vaccines can cause both autoimmunity and neurological damage.

TITLE

Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity

CITATION

Shaw C, Tomljenovic L. Immunologic Research. 2013;56:304–316.

SUMMARY

“In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome. Aluminum is added to vaccines to help the vaccine work more effectively, but unlike dietary aluminum which will usually clear rapidly from the body, aluminum used in vaccines and injected is designed to provide a long-lasting cellular exposure. Thus, the problem with vaccine-derived aluminum is really twofold: It drives the immune response even in the absence of a viral or bacterial threat and it can make its way into the central nervous system. It is not really a matter of much debate that aluminum in various forms can be neurotoxic.”

View Abstract

TAGS
Published: 2013
SYNOPSIS

Research has determined there is a subgroup of the population that has hypersensitivity to the toxicity of thimerosal yet thimerosal containing vaccines are administered to all without consideration to this important fact. We can ban peanuts from schools because a subpopulation is allergic to them, so why is thimerosal still contained in our vaccines?

TITLE

B-lymphocytes from a population of children with autism spectrum disorder and their unaffected siblings exhibit hypersensitivity to thimerosal.

CITATION

Sharpe MA, Gist TL, Baskin DS. J Toxicol. 2013;2013:801517. doi: 10.1155/2013/801517. Epub 2013 Jun 9.

SUMMARY

Two medications (valproate and thalidomide) have been definitively shown to be causative with regards to autism spectrum disorder (ASD). Both of these medications share a common trait of inhibiting cell proliferation. Thus, these researchers set out to determine if thimerosal can inhibit cell proliferation using doses of thimerosal which reflect the concentrations that infants are exposed to via vaccinations. The design of this experiment was chosen to be able to distinguish between shared or different in utero environments among families with an ASD member. To accomplish this goal, B-cells were collected from, ASD individuals, their unaffected fraternal twins representing a shared in utero environment, and their unaffected nontwin siblings. In the same manner, B-cells were collected from control families with no history of ASD which were matched for age/sex/ethnicity and compared to ASD families. It was determined that there is a hypersensitivity to thimerosal among a subpopulation of ASD families. The target of thimerosal toxicity is the mitochondria and cell proliferation was inhibited at a dose that was lower than that required to cause cell death.  Among the hypersensitive population, the dose of thimerosal that could inhibit cell proliferation was found to be only 40% of that needed to inhibit proliferation in the control group. Whether a twin or sibling was hypersensitive was dependent on having another family member with hypersensitivity. This finding implies there is a genetic component to thimerosal hypersensitivity. Among the ASD families with hypersensitivity oxidative stress was determined to be the contributing factor. Poor antioxidant status, high lactate levels, and elevated markers of oxidative stress are a common finding among individuals with ASD. In 2008 the case of Hannah Poling was awarded compensation under the United States National Vaccine Injury Compensation Program. It was claimed that her vaccines induced a mitochondrial encephalopathy that resulted in autism. Since the mitochondria is the most significant target of thimerosal toxicity, it is particularly poignant to know that a lowering of antioxidant status by any other additional conditions such as infections or co-exposure to other toxins would further sensitize mitochondria to the damaging effects of thimerosal. These researchers state that their work, “…supports a multi-insult model of ASD causation where many individuals have the genetic background that makes them vulnerable to a particular type of insult at a particular time in their brain development…”. Just like valproate and thalidomide which are the only 2 accepted causative agents for ASD, this research has demonstrated that thimerosal is also capable of inhibiting cell proliferation.

 

TAGS
Published: 2013
SYNOPSIS

Fully vaccinated children require much more emergency care than undervaccinated children.

TITLE

A Population-Based Cohort Study of Undervaccination in 8 Managed Care Organizations Across the United States

CITATION

Jason M. Glanz, PhD; Sophia R. Newcomer, MPH; Komal J. Narwaney, MD, PhD; Simon J. Hambidge, MD, PhD; Matthew F. Daley, MD; Nicole M. Wagner, MPH, et al. JAMA Pediatrics, 2013;167(3):274-281.

SUMMARY

“Children who were undervaccinated because of parental choice had lower rates of outpatient visits, lower rates of ED [emergency room] encounters… undervaccinated children had lower outpatient visit rates compared with children who were age-appropriately vaccinated.”

View Abstract

TAGS
Published: 2013
SYNOPSIS

Infants receiving mercury-containing vaccines had much higher rates of autism than infants receiving vaccines without mercury.

TITLE

A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States

CITATION

Geier DA, Hooker BS, Kern JK, King PG, Sykes LK, Geier MR. Translational Neurodegeneration. 2013;2:25.

SUMMARY

“The present study provides new epidemiological evidence supporting an association between increasing organic-Hg [mercury] exposure from Thimerosal-containing childhood vaccines and the subsequent risk of ASD [autism] diagnosis.”

View Abstract

TAGS
Published: 2013
SYNOPSIS

Scientists from Mexico and Israel explain adjuvants (aluminum) used in vaccines can induce autoimmunity.

TITLE

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum

CITATION

Vera-Lastra O, Medina G, Del-Pilar Cruz Dominguez M, Jara LJ. Expert Reviews-Clinical Immunology. 2013;9(4):361-373.

SUMMARY

Activation of the immune system by adjuvants could trigger manifestations of autoimmunity or autoimmune disease. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) includes postvaccination phenomena, macrophagic myofasciitis (MMF), Gulf War syndrome and siliconosis. Various adjuvants used in vaccines enhance a specific immune response against antigens and may produce autoimmunity and autoimmune disease in experimental models and humans. “The clinical and laboratory data support an association between adjuvants and autoimmune diseases.”

View Abstract

TAGS
Published: 2013
SYNOPSIS

There is a connection between infant and prenatal thimerosal exposure and neurological disorders.

TITLE

Low-dose mercury exposure in early life: Relevance of thimerosal to fetuses, newborns and infants

CITATION

Dórea JG. Current Medicinal Chemistry. 2013;20:4060-4069.

SUMMARY

This review article highlights the scientifically affirmed connection between infant and prenatal thimerosal exposure and neurological disorders, including tic disorder, which has been shown to be much more prevalent in children with autism. The author also delineates the use of thimerosal in vaccines in developing countries at a greater exposure level than developed countries such as the U.S.

View Abstract

TAGS
Published: 2012
SYNOPSIS

Incidences of Chicken Pox are decreasing Shingles are increasing and the costs associated with the increase in Shingles incidences have exceed the cost savings from the decrease in Chicken Pox cases.

TITLE

Review of the United States universal varicella vaccination program: Herpes zoster incidence rates, cost-effectiveness, and vaccine efficacy based primarily on the Antelope Valley Varicella Active Surveillance Project data

CITATION

G.S. Goldman and P.G. King Vaccine, 31 (2013) 1680–1694.

SUMMARY

In 2000, varicella incidence dramatically declined to 70% of the prevaccine rate but reports of Herpes zoster, Shingles, significantly increased among adults aged 20–69 years from 2000 to 2001. Even children with a prior history of varicella demonstrated Shingles rates similar to adults. By 2002, the efficacy of the varicella vaccination had declined well below 80% and the costs of the increased shingles rate have exceeded the cost savings from varicella-disease reductions.

View Abstract

TAGS
Published: 2012
SYNOPSIS

Danish researchers found children 8-times more likely to have a febrile seizure on the day of vaccination of DTaP-IPV-HiB vaccine.

TITLE

Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus, Acellular Pertussis, Inactivated Poliovirus, and Haemophilus Influenzae Type b

CITATION

Yuelian Sun, Jakob Christensen, Anders Hviid, Jiong Li, Et al. Journal of the Amercian Medical Association, February 22/29, 2012—Vol 307, No. 8.

SUMMARY

“DTaP-IPV-Hib vaccination was associated with an increased risk of febrile seizures on the day of the first 2 vaccinations given at 3 and 5 months.”

View Abstract

TAGS
Published: 2012
SYNOPSIS

Surprisingly, even though the children with the best nutritional status were vaccinated early, early DTP vaccination was associated with increased mortality.

TITLE

Early diphtheria-tetanus-pertussis vaccination associated with higher female mortality and no difference in male mortality in a cohort of low birthweight children: an observational study within a randomised trial.

CITATION

Aaby P, Ravn H, Roth A, Rodrigues A, Lisse IM, Diness BR, Lausch KR, Lund N, Rasmussen J, Biering-Sorensen S, Whittle H, Benn CS. Archives of Disease in Childhood. 2012 Aug;97(8):685-91. doi: 10.1136/archdischild-2011-300646. Epub 2012 Feb 13.

SUMMARY

Studies from low-income countries have suggested that diphtheria-tetanus-pertussis (DTP) vaccine provided after Bacille Calmette-Guerin (BCG) vaccination may have a negative effect on female survival. The authors examined the effect of DTP in a cohort of low birthweight (LBW) infants and found, surprisingly, even though the children with the best nutritional status were vaccinated early, early DTP vaccination was associated with increased mortality for girls.

View Abstract

TAGS

, , ,

Published: 2012
SYNOPSIS

Canadian researchers review literature on autoimmunity and neurological risks from vaccine adjuvant aluminum, express doubts regarding safety testing.

TITLE

Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations

CITATION

L Tomljenovic, CA Shaw. Lupus. 2012;21:223–230.

SUMMARY

“Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In spite of the widespread agreement that vaccines are largely safe and serious adverse complications are extremely rare, a close scrutiny of the scientific literature does not support this view. For example, to date, the clinical trials that could adequately address vaccine safety issues have not been conducted (i.e., comparing health outcomes in vaccinated versus non-vaccinated children). Infants and young children should not be viewed as ‘small adults.’ Their unique physiology makes them much more vulnerable to noxious environmental insults in comparison with the adult population. In spite of this, children are routinely exposed to much higher levels of Al vaccine adjuvants than adults, even though adequate safety data on these compounds are lacking. That Al vaccine adjuvants can induce significant autoimmune conditions in humans can hardly be disputed, although still debatable is how common such side effects are. However, the existing data (or lack thereof) raise questions on whether the current vaccines aimed at pediatric populations can be accepted as having adequate safety profiles. Because infants and children represent those who may be most at risk for complications following vaccination, a more rigorous evaluation of potential vaccine-related adverse health impacts in pediatric populations than what has been provided to date is urgently needed.”

View Abstract

TAGS
Published: 2012
SYNOPSIS

Infants who received more vaccines had much higher hospitalization and death rates than infants who received fewer vaccines.

TITLE

Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010

CITATION

GS Goldman, NZ Miller. Human and Experimental Toxicology, 2012, 31(10) 1012–1021.

SUMMARY

“The hospitalization rate increased linearly from 11.0% (107 of 969) for 2 doses to 23.5% (661 of 2817) for 8 doses and decreased linearly from 20.1% (154 of 765) for children aged < 0.1 year to 10.7% (86 of 801) for children aged 0.9 year. Our findings show a positive correlation between the number of vaccine doses administered and the percentage of hospitalizations and deaths. Since vaccines are given to millions of infants annually, it is imperative that health authorities have scientific data from synergistic toxicity studies on all combinations of vaccines that infants might receive. Finding ways to increase vaccine safety should be the highest priority."

View Abstract

TAGS
Published: 2011
SYNOPSIS

Canadian researchers report vaccine aluminum and autism prevalence related.

TITLE

Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?

CITATION

Tomljenovic L, Shaw CA. Journal of Inorganic Biochemistry. 2011;105:1489-1499.

SUMMARY

“Dysfunctional immunity and impaired brain function are core deficits in ASD. Aluminum (Al), the most commonly used vaccine adjuvant, is a demonstrated neurotoxin and a strong immune stimulator. Hence, adjuvant Al has the potential to induce neuroimmune disorders. The application of the Hill’s criteria to these data indicates that the correlation between Al in vaccines and ASD may be causal. Because children represent a fraction of the population most at risk for complications following exposure to Al, a more rigorous evaluation of Al adjuvant safety seems warranted. By satisfying eight of the Hill’s criteria for establishing causality applicable to our study, we show that Al-adjuvanted vaccines may be a significant etiological factor in the rising prevalence of ASD in the Western world. We also show that children from countries with the highest ASD prevalence appear to have a much higher exposure to Al from vaccines, particularly at 2 months of age.”

View Abstract

TAGS
Published: 2010
SYNOPSIS

Researchers warn of sizable difference in individual reaction to vaccines, stress need to avoid increasing side effects of vaccines.

TITLE

Interindividual variations in the efficacy and toxicity of vaccines

CITATION

Chandan Thomasa, Majid Moridanib. Toxicology 278, 2010 204-210.

SUMMARY

“A number of currently available vaccines have shown significant differences in the magnitude of immune responses and toxicity in individuals undergoing vaccination. A number of factors may be involved in the variations in immune responses, which include age, gender, race, amount and quality of the antigen, the dose administered and to some extent the route of administration, and genetics of immune system. Hence, it becomes imperative that researchers have tools such as genomics and proteomics at their disposal to predict which set of population is more likely to be non-responsive or develop toxicity to vaccines.. With the increasing number of side effects associated with a number of vaccines reported over the years, it has become imperative to develop new technologies that can effectively assist in the development and evaluation of vaccines for efficacy and toxicity.”

View Abstract

TAGS
Published: 2010
SYNOPSIS

Scientists review literature and raise concerns about denial of environmental toxin link to autism.

TITLE

Sorting out the spinning of autism: heavy metals and the question of incidence

CITATION

DeSoto MC, Hitlan RT. ACTA Neurobiological Experimentals. 2010;70:165–176.

SUMMARY

“In this paper, we argue that increasingly over the past decade, positions that deny a link to environmental toxins and autism are based on relatively weak science and are disregarding the bulk of scientific literature. The question about toxic exposure and autism is open, with the weight of evidence favoring a connection that is not well understood. Although it is not possible to say with certainty, it seems likely that the connection would be mediated by genetic susceptibility and ability to detoxify. That is, some people have genotypes that confer higher susceptibility to toxic exposures. If so, then 50 years ago few people would have had enough toxic exposure to have the neurological changes that result in autism.”

View Abstract

TAGS
Published: 2010
SYNOPSIS

Baby monkeys given U.S. vaccine schedule had brain abnormalities in region responsible for social and emotional development.

TITLE

Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study

CITATION

Laura Hewitson, Brian J. Lopresti, Carol Stott, N. Scott Mason and Jaime Tomko1. ACTA Neurobiological Experimentals, 2010 70: 147–164.

SUMMARY

“The data suggest that vaccine exposure may be associated with significant disturbances in central opioidergic pathways in this model… Volumetric analyses identified significantly greater total brain volume in exposed compared with unexposed animals at both measured time points. These results raise the possibility that multiple vaccine exposures during the previous 3-4 months may have had a significant impact on brain growth and development.”

View Abstract

TAGS
Published: 2010
SYNOPSIS

SUNY-Stony Brook scientists find boys receiving the hepatitis B vaccine series are three times more likely to have autism.

TITLE

Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997-2002

CITATION

Gallagher C, Goodman M. Journal of Toxicology and Environmental Health, Part A. 2010;73:1665–1677.

SUMMARY

“Boys vaccinated as neonates had threefold greater odds for autism diagnosis compared to boys never vaccinated or vaccinated after the first month of life. Findings suggest that U.S. male neonates vaccinated with the hepatitis B vaccine prior to 1999 (from vaccination record) had a threefold higher risk for parental report of autism diagnosis compared to boys not vaccinated as neonates during that same time period.”

View Abstract

TAGS
Published: 2010
SYNOPSIS

Acellular Pertussis vaccination interferes with the optimal clearance of B. parapertussis and enhances the performance of this pathogen. Our data raise the possibility that widespread acellular Pertussis vaccination can create hosts more susceptible to B. parapertussis infection.

TITLE

Acellular pertussis vaccination facilitates Bordetella parapertussis infection in a rodent model of bordetellosis

CITATION

Gráinne H. Long, Alexia T. Karanikas, Eric T. Harvill, Andrew F. Read and Peter J. Hudson, Proceedings of the Royal Society B, Biological Sciences; 03 March, 2010; Volume 277; https://doi.org/10.1098/rspb.2010.0010

SUMMARY

Despite over 50 years of population-wide vaccination, whooping cough incidence is on the rise. Although Bordetella pertussis is considered the main causative agent of whooping cough in humans, Bordetella parapertussis infections are not uncommon. The widely used acellular whooping cough vaccines (aP) are comprised solely of B. pertussis antigens that hold little or no efficacy against B. parapertussis. Here, we ask how aP vaccination affects competitive interactions between Bordetella species within co-infected rodent hosts and thus the aP-driven strength and direction of in-host selection. We show that aP vaccination helped clear B. pertussis but resulted in an approximately 40-fold increase in B. parapertussis lung colony-forming units (CFUs). Such vaccine-mediated facilitation of B. parapertussis did not arise as a result of competitive release; B. parapertussis CFUs were higher in aP-relative to sham-vaccinated hosts regardless of whether infections were single or mixed. Further, we show that aP vaccination impedes host immunity against B. parapertussis—measured as reduced lung inflammatory and neutrophil responses. Thus, we conclude that aP vaccination interferes with the optimal clearance of B. parapertussis and enhances the performance of this pathogen. Our data raise the possibility that widespread aP vaccination can create hosts more susceptible to B. parapertussis infection.

View Abstract

TAGS
Published: 2010
SYNOPSIS

British and Swedish scientists raise concerns about limited understanding of vaccine aluminum’s impact on the human body, raise risk of autoimmune response.

TITLE

The immunobiology of aluminium adjuvants: how do they really work?

CITATION

Exley C, Siesjo P, Eriksson H. Trends in Immunology. 2010;31:103-109.

SUMMARY

“Boys vaccinated as neonates had threefold greater odds for autism diagnosis compared to boys never vaccinated or vaccinated after the first month of life. Findings suggest that U.S. male neonates vaccinated with the hepatitis B vac- cine prior to 1999 (from vaccination record) had a threefold higher risk for parental report of autism diagnosis compared to boys not vaccinated as neonates during that same time period.”

View Abstract

TAGS
Published: 2010
SYNOPSIS

It is feasible that vaccinations may contribute to the mosaic of autoimmunity.

TITLE

Vaccines and autoimmune diseases of the adult

CITATION

Orbach H, Agmon-Levin N, Zandman-Goddard G. Discovery Medicine. 2014;10(2):101-107.

SUMMARY

Infectious agents contribute to the environmental factors involved in the development of autoimmune diseases possibly through molecular mimicry mechanisms. Hence, it is feasible that vaccinations may also contribute to the mosaic of autoimmunity. Evidence for the association of vaccinations and the development of these diseases is presented in this review.

View Abstract

TAGS
Published: 2009
SYNOPSIS

Vaccine aluminum injected into mice created significant motor deficits and motor neuron degeneration.

TITLE

Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration

CITATION

Christopher A. Shaw and Michael S. Petrik. Journal Inorganic Biochemistry, 2009 November; 103(11): 1555.

SUMMARY

“Aluminum-treated mice showed significantly increased apoptosis of motor neurons and increases in reactive astrocytes and microglial proliferation within the spinal cord and cortex. Morin stain detected the presence of aluminum in the cytoplasm of motor neurons with some neurons also testing positive for the presence of hyper-phosphorylated tau protein, a pathological hallmark of various neurological diseases, including Alzheimer’s disease and frontotemporal dementia. A second series of experiments was conducted on mice injected with six doses of aluminum hydroxide. Behavioural analyses in these mice revealed significant impairments in a number of motor functions as well as diminished spatial memory capacity. The demonstrated neurotoxicity of aluminum hydroxide and its relative ubiquity as an adjuvant suggest that greater scrutiny by the scientific community is warranted. Overall, the results reported here mirror previous work that has clearly demonstrated that aluminum, in both oral and injected forms, can be neurotoxic.”

View Abstract

TAGS
Published: 2009
SYNOPSIS

Newborn monkeys given a mercury-containing hepatitis b vaccine had significant delays in neonatal reflexes and neurological development.

TITLE

Delayed acquisition of neonatal reflexes in newborn primates receiving a thimerosal-containing Hepatitis B vaccine: Influence of gestational age and birth weight

CITATION

Laura Hewitson, Lisa A. Houser, Carol Stott, Gene Sackett, Jaime L. Tomko, David Atwood, Lisa Blue, E. Railey White, Andrew J. Wakefield. NeuroToxicology, 2009; doi:10.1016/j.neuro.2009.09.008.

SUMMARY

“In summary, this study provides preliminary evidence of abnormal early neurodevelopmental responses in male infant rhesus macaques receiving a single dose of Th-containing HB vaccine at birth and indicates that further investigation is merited.”

View Abstract

TAGS
Published: 2009
SYNOPSIS

French scientists report aluminum from vaccines causes chronic cognitive dysfunction.

TITLE

Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction

CITATION

Maryline Couette, Marie-Françoise Boisse, Patrick Maison, Pierre Brugieres, Pierre Cesaro, Xavier Chevalier, Romain K. Gherardi, Anne-Catherine Bachoud-Levi, François-Jérôme Authier. Journal of Inorganic Biochemistry, 2009.

SUMMARY

“In conclusion, long-term persistence of vaccine-derived aluminum hydroxide within the body assessed by MMF is associated with cognitive dysfunction, not solely due to chronic pain, fatigue and depression. In conclusion, this work is the first firm demonstration that cognitive dysfunction is a central feature in MMF, this dysfunction being much more frequent and severe than suspected by routine neurological evaluation. Instead of being a non-specific bystander effect of pain, fatigue or depression, MACD seems to reflect an underlying organic, inflammatory or toxic, brain involvement.”

View Abstract

TAGS
Published: 2009
SYNOPSIS

Swedish researchers found that children who had natural measles infection had much lower rates of allergy than children vaccinated against measles.

TITLE

Allergic disease and atopic sensitization in children in relation to measles vaccination and measles infection

CITATION

Rosenlund H, Bergstrom A, Alm JS, … PARSIFAL Study Group. Pediatrics. 2009;123(3):771-778.

SUMMARY

In these analyses, measles infection [natural measles] was inversely associated with any allergic symptom or physician’s diagnosis of allergy, suggesting that natural measles infection may protect against allergies in children.

View Abstract

TAGS
Published: 2008
SYNOPSIS

Higher aluminum intake from drinking water is associated with an increased risk of cognitive decline, dementia and Alzheimer’s disease.

TITLE

Aluminum and silica in drinking water and the risk of Alzheimer’s disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort

CITATION

Rondeau V, Jacqmin-Gadda H, Commenges D, Helmer C, Dartigues JF. Aluminum and silica in drinking water and the risk of Alzheimer’s disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort. American Journal of Epidemiology. 2009;169(4):489-496.

SUMMARY

A long-term study in Southern France found that a higher intake of aluminum from drinking water was linked to an increased risk of cognitive decline, dementia and Alzheimer’s disease. Conversely, an increase in silica intake (10 mg/day) reduced the risk of dementia. A unique feature of the study, which followed elderly individuals for 15 years, was its measurement of individual daily intake of drinking water (both tap and bottled water), in addition to assessing the geographical concentrations of aluminum and silica.  

View Abstract

TAGS
Published: 2008
SYNOPSIS

Boys receiving the hepatitis B vaccine series were nine times more likely to need special education and be developmentally disabled.

TITLE

Hepatitis B triple series vaccine and developmental disability in US children aged 1-9 years

CITATION

Gallagher C, Goodman M. Toxicological and Environmental Chemistry. 2008;90(5):997-1008.

SUMMARY

This study investigated the association between vaccination with the hepatitis B triple series vaccine (pre-2000) and subsequent developmental disability. The odds of receiving special education were approximately nine times as great for vaccinated boys as for unvaccinated boys, after adjustment for confounders. The evidence, statistically significant, suggests that boys in United States who were vaccinated with the triple series hepatitis B vaccine were more susceptible to developmental disability than were unvaccinated boys.

View Abstract

TAGS
Published: 2008
SYNOPSIS

Three gene variations are associated with adverse reactions to smallpox vaccination.  

TITLE

Genetic Basis for Adverse Events Following Smallpox Vaccination

CITATION

Reif DM, McKinney BA, Motsinger AA, Chanock SJ, Edwards KM, Rock MT, Moore JH, Crowe Jr. JE. Genetic basis for adverse events following smallpox vaccination. The Journal of Infectious Diseases. 2008;198(1):16-22.

SUMMARY

A pair of NIH-funded studies identified three genetic variations that make people more susceptible to systemic adverse events following smallpox vaccination. By studying the smallpox vaccine, the researchers focused on a vaccine historically noted for frequently causing adverse reactions in population-wide vaccination programs. In the two studies, 16/96 and 24/46 individuals experienced systemic adverse events after vaccination, and three candidate genes (MTHFR, IRF1 and IL4) had the strongest association with the adverse events. In susceptible individuals, “vaccination appears to trigger an acute inflammatory response that is excessive.”

View Abstract

TAGS
Published: 2008
SYNOPSIS

A CDC-sponsored database showed much higher rates of neurodevelopmental disabilities from mercury-containing vaccines.

TITLE

Thimerosal exposure in infants and neurodevelopmental disorders: An assessment of computerized medical records in the Vaccine Safety Datalink

CITATION

Young HA, Geier DA, Geier MR. Journal of the Neurological Sciences. 2008;121:626-631.

SUMMARY

“Consistent significantly increased rate ratios were observed for autism, autism spectrum disorders, tics, attention deficit disorder, and emotional disturbances with Hg [mercury] exposure from TCVs [thimerosal-containing vaccines]. By contrast, none of the control outcomes had significantly increased rate ratios with Hg exposure from TCVs.”

View Abstract

TAGS
Published: 2008
SYNOPSIS

Australian scientists describe the role of vaccines in triggering acute disseminated encephalomyelitis (“ADEM”).

TITLE

Post-vaccination encephalomyelitis: Literature review and illustrative case

CITATION

William Huynh, Dennis J. Cordato, Elias Kehdi, Lynette T. Masters, Chris Dedousis. Journal of Clinical Neuroscience, 15 (2008) 1315–1322.

SUMMARY

“Post-infectious and post-immunization encephalomyelitis make up about three-quarters of cases, where the timing of a febrile event is associated with the onset of neurological disease. Post-vaccination Acute disseminated encephalomyelitis has been associated with several vaccines such as rabies, diphtheria-tetanus-polio, smallpox, measles, mumps, rubella, Japanese B encephalitis, pertussis, influenza, hepatitis B, and the Hog vaccine. We review ADEM with particular emphasis on vaccination as the precipitating factor.”

View Abstract

TAGS
Published: 2008
SYNOPSIS

Children who delayed the timing of the DPT vaccine had lower rates of asthma.

TITLE

Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma?

CITATION

McDonald KL, Huq SI. Journal of the American Academy of Allergy, Asthma and Immunology. 2008;121:626-631.

SUMMARY

“Early childhood immunizations have been viewed as promoters of asthma development by stimulating a T(H)2-type immune response or decreasing microbial pressure, which shifts the balance between T(H)1 and T(H)2 immunity. Among 11, 531 children who received at least 4 doses of DPT, the risk of asthma was reduced to (1/2) in children whose first dose of DPT was delayed by more than 2 months.”

View Abstract

TAGS