Vaccines
SYNOPSIS
Some individuals are at risk of developing autoimmune/inflammatory syndrome induced by adjuvants (ASIA).
TITLE
Predicting post-vaccination autoimmunity: who might be at risk?
CITATION
Soriano A, Nesher G, Shoenfeld Y. Pharmacological Research, 2015;92:18-22. Epub 2014 Sep 30.
SUMMARY
It has been postulated that autoimmunity could be triggered or enhanced by a vaccine’s immunogen contents, as well as by adjuvants, which are used to increase the immune reaction to the immunogen. Fortunately, vaccination-related ASIA (autoimmune/inflammatory syndrome induced by adjuvants) is uncommon. Yet, by defining individuals at risk, it may be possible to further limit the number of individuals developing post-vaccination ASIA.
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Vaccines are implicated in the epidemic of childhood food allergies.
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Evidence that food proteins in vaccines cause the development of food allergies and its implications for vaccine policy
CITATION
Arumugham V. Journal of Developing Drugs. 2015;4:137.
SUMMARY
Studies, including by the Institute of Medicine, have demonstrated that food proteins contained in vaccines/injections can induce food allergy. Allergen quantities in vaccines are unregulated. C-section births bias a newborn’s immune system toward IgE synthesis due to the development of a suboptimal gut microbiome. Vaccines contain adjuvants such as aluminum compounds and pertussis toxin that also bias toward IgE synthesis. Over several decades, C-section birth rates have gone up 50%, and the vaccine schedule has increased the number of vaccine shots, with up to five vaccines administered simultaneously. “Given these conditions, the predictable and observed outcome is a food allergy epidemic.”
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Researchers found that febrile seizures occurred in roughly one in every 1,000 children who were given the MMR vaccine and two genetic variants came to light that pointed to a higher risk of a febrile seizure in the second week following MMR vaccination.
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Common variants associated with general and MMR vaccine–related febrile seizures
CITATION
Bjarke Feenstra, Bjorn Pasternak, Frank Geller, Lisbeth Carstensen, et. al. Nature Genetics 46, 1274-1282; 26 October, 2014.
SUMMARY
Febrile seizures represent a serious adverse event following measles, mumps and rubella (MMR) vaccination. We conducted a series of genome-wide association scans comparing children with MMR-related febrile seizures, children with febrile seizures unrelated to vaccination and controls with no history of febrile seizures. Two loci were distinctly associated with MMR-related febrile seizures. Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes and a region associated with magnesium levels.
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FDA’s instruction to health providers that “there is no biologically plausible way in which HPV vaccine could cause infertility” is not science-based and compromises safety monitoring by undermining reporting efficiency, safety signaling and informed consent.
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Adolescent premature ovarian insufficiency following human papillomavirus vaccination: A case series seen in general practice
CITATION
Little DT, Ward HR. Journal of Investigative Medicine-High Impact Case Reports. 2014;2(4):2324709614556129.
SUMMARY
Published case reports point to a possible link between quadrivalent human papillomavirus (HPV) vaccine and premature ovarian failure. Declining menstrual function in girls aged 14, 15, and 20 years followed quadrivalent HPV vaccination and preceded premature ovarian failure. However, long-term follow-up after HPV vaccination has not surveyed ovarian function, nor recorded, measured or analyzed symptoms or signs of dysfunction. Disparagement of adverse event reporting by licensing bodies, which instruct health providers that “there is no biologically plausible way in which HPV vaccine could cause infertility,” is not science-based and compromises safety monitoring by undermining “reporting efficiency,” safety signaling and informed consent. In the absence of sound research, public reassurance that “studies have not found ovarian failure to be associated with HPV vaccination” may be harmful to vaccine confidence.
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Neurodevelopmental disorders are much more common in children who received mercury-containing vaccines.
TITLE
A dose-response relationship between organic mercury exposure from thimerosal-containing vaccines and neurodevelopmental disorders
CITATION
Geier DA, Hooker BS, Kern JK, King PG, Sykes LK, Geier MR. International Journal of Environmental Research and Public Health. 2014;11:9156-9170.
SUMMARY
On a per microgram of organic-mercury (Hg) basis, pervasive developmental disorder, specific developmental disorder, tic disorder and hyperkinetic syndrome of childhood cases were significantly more likely than controls to receive increased organic-Hg exposure. This study provides new epidemiological evidence supporting a significant relationship between increasing organic-Hg exposure from vaccines and the subsequent risk of a neurodevelopmental disorder diagnosis.
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Chinese scientists find mice injected with thimerosal (vaccine mercury) have behavioral impairments similar to autism.
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Transcriptomic analyses of neurotoxic effects in mouse brain after intermittent neonatal administration of thimerosal
CITATION
Li X, Qu F, Xie W, et al. Toxicological Sciences. 2014;139:452–465.
SUMMARY
“Thimerosal-treated mice exhibited neural development delay, social interaction deficiency, and inclination of depression. Apparent neuropathological changes were also observed in adult mice neonatally treated with thimerosal. High-throughput RNA sequencing of autistic-behaved mice brains revealed the alternation of a number of canonical pathways involving neuronal development, neuronal synaptic function, and the dysregulation of endocrine system.”
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Newborns have been overexposed to aluminum.
TITLE
Aluminum exposure and toxicity in neonates: a practical guide to halt aluminum overload in the prenatal and perinatal periods.
CITATION
Fanni D, et al. World Journal of Pediatrics, 2014 May; 10(2):101-7.
SUMMARY
During the last years, human newborns have been overexposed to biologically reactive aluminum, with possible relevant consequences on their future health and on their susceptibility to a variety of diseases. Children, newborns and particularly preterm neonates are at an increased risk of aluminum toxicity because of their relative immaturity. Based on recent original publications and classical data of the literatures, we reviewed the aluminum content in mother’s food during the intrauterine life as well as in breast milk and infant formula during lactation. We also determined the possible role of aluminum parenteral nutrition solutions, in adjuvants of vaccines and in pharmaceutical products.
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There has been an epidemic of inflammatory diseases that has paralleled the epidemic on iatrogenic immune stimulation with vaccines. The epidemic of diabetes/prediabetes appears to be accelerating at a time when the prevalence of obesity has stabilized, indicating that the negative feedback system of the immune system has been over whelmed.
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Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases
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SUMMARY
There has been an epidemic of inflammatory diseases that has paralleled the epidemic on iatrogenic immune stimulation with vaccines. Extensive evidence links vaccine induced immune over load with the epidemic of type 1 diabetes. More recent data indicates that obesity, type 2 diabetes and other components of metabolic syndrome are highly associated with immunization and may be manifestations of the negative feedback loop of the immune system reacting to the immune overload. The epidemic of diabetes/prediabetes appears to be accelerating at a time when the prevalence of obesity has stabilized, indicating that the negative feedback system of the immune system has been over whelmed. The theory of vaccine induced immune overload can explain the key observations that have confounded many competing hypothesis. The current paper reviews the evidence that vaccine induced immune overload explains the disconnect between the increase in prediabetes and nonalcoholic fatty liver at a time when the obesity epidemic is waning in children.
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These data provide a plausible explanation for pertussis resurgence and suggest that attaining herd immunity will require the development of improved vaccination strategies that prevent B. pertussis colonization and transmission.
TITLE
Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model
CITATION
Jason M. Warfel, Lindsey I. Zimmerman, and Tod J. Merkel; Proceedings of the National Academy of Sciences; January 14, 2014, 111 (2), 787-792; https://doi.org/10.1073/pnas.1314688110.
SUMMARY
In this study, researchers found that current acellular pertussis (aP) vaccines fail to prevent colonization and transmission. Nonhuman primates vaccinated with current acellular Pertussis (aP) were protected from severe symptoms but not infection and readily transmitted Bordetella pertussis to contacts.
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UC-Boulder professor says the autism epidemic is real and therefore must be the product of an environmental factor.
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A comparison of temporal trends in United States autism prevalence to trends in suspected environmental factors
CITATION
Nevison CD. Environmental Health. 2014;13:73.
SUMMARY
“Diagnosed autism prevalence has risen dramatically in the U.S over the last several decades and continued to trend upward as of birth year 2005. The increase is mainly real and has occurred mostly since the late 1980s. In contrast, children’s exposure to most of the top ten toxic compounds has remained flat or decreased over this same time frame. Environmental factors with increasing temporal trends can help suggest hypotheses for drivers of autism that merit further investigation.”
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Israeli and Italian researchers demonstrate that exposure to aluminum in vaccines can lead to autoimmune and brain dysfunction.
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Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects
CITATION
Perricone C, Colafrancesco S, Mazor RD, Soriano A, Agmon-Levin N, Shoenfeld Y. Journal of Autoimmunity. 2013;47:1-16.
SUMMARY
Environmental factors play a critical role in the induction of autoimmunity, with an interplay between genetic susceptibility and environment. Several neurologic demyelinating diseases have been reported following vaccination, notably Guillain-Barre syndrome (GBS) and acute disseminated encephalomyelitis (ADEM) (an inflammatory disease of the central nervous system). A number of the most common vaccines appear to have some involvement with autoimmunity.
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Israeli, Italian, and Canadian researchers tie HPV vaccine to primary ovarian failure.
TITLE
Human Papilloma Virus Vaccine and Primary Ovarian Failure: Another Facet of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants
CITATION
Selena Colafrancesco, Carlo Perricone, Lucija Tomljenovic, Yehuda Shoenfeld. American Journal of Reproductive Immunology, 2013.
SUMMARY
“We documented here the evidence of the potential of the HPV vaccine to trigger a life-disabling autoimmune condition. The increasing number of similar reports of post HPV vaccine-linked autoimmunity and the uncertainty of long-term clinical benefits of HPV vaccination are a matter of public health that warrants further rigorous inquiry.”
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Following implementation of changes in a pediatric medical practice to address autism risks, no new cases of autism occurred.
TITLE
Can awareness of medical pathophysiology in autism lead to primary care autism prevention strategies?
Citation
Mumper E. North American Journal of Medicine and Science. 2013;6:134-144.
Summary
In 2005, the author’s pediatric practice implemented seven changes to address autism risks, focusing on minimizing environmental toxicant exposure, encouraging prolonged breastfeeding, recommending probiotics, providing nutritional counseling, limiting use of antibiotics and acetaminophen and allowing a modified vaccine schedule. No new cases of autism occurred in children born between 2005 and 2011, even though the CDC autism rate would have predicted about six new cases in the practice over that period. The author cautions that “epidemiology may be too blunt a tool to determine all risks for subsets of the population who may be more vulnerable to vaccine reactions.”
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Canadian researchers: aluminum in vaccines can cause both autoimmunity and neurological damage.
TITLE
Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity
CITATION
Shaw C, Tomljenovic L. Immunologic Research. 2013;56:304–316.
SUMMARY
“In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome. Aluminum is added to vaccines to help the vaccine work more effectively, but unlike dietary aluminum which will usually clear rapidly from the body, aluminum used in vaccines and injected is designed to provide a long-lasting cellular exposure. Thus, the problem with vaccine-derived aluminum is really twofold: It drives the immune response even in the absence of a viral or bacterial threat and it can make its way into the central nervous system. It is not really a matter of much debate that aluminum in various forms can be neurotoxic.”
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Research has determined there is a subgroup of the population that has hypersensitivity to the toxicity of thimerosal yet thimerosal containing vaccines are administered to all without consideration to this important fact. We can ban peanuts from schools because a subpopulation is allergic to them, so why is thimerosal still contained in our vaccines?
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B-lymphocytes from a population of children with autism spectrum disorder and their unaffected siblings exhibit hypersensitivity to thimerosal.
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SUMMARY
Two medications (valproate and thalidomide) have been definitively shown to be causative with regards to autism spectrum disorder (ASD). Both of these medications share a common trait of inhibiting cell proliferation. Thus, these researchers set out to determine if thimerosal can inhibit cell proliferation using doses of thimerosal which reflect the concentrations that infants are exposed to via vaccinations. The design of this experiment was chosen to be able to distinguish between shared or different in utero environments among families with an ASD member. To accomplish this goal, B-cells were collected from, ASD individuals, their unaffected fraternal twins representing a shared in utero environment, and their unaffected nontwin siblings. In the same manner, B-cells were collected from control families with no history of ASD which were matched for age/sex/ethnicity and compared to ASD families. It was determined that there is a hypersensitivity to thimerosal among a subpopulation of ASD families. The target of thimerosal toxicity is the mitochondria and cell proliferation was inhibited at a dose that was lower than that required to cause cell death. Among the hypersensitive population, the dose of thimerosal that could inhibit cell proliferation was found to be only 40% of that needed to inhibit proliferation in the control group. Whether a twin or sibling was hypersensitive was dependent on having another family member with hypersensitivity. This finding implies there is a genetic component to thimerosal hypersensitivity. Among the ASD families with hypersensitivity oxidative stress was determined to be the contributing factor. Poor antioxidant status, high lactate levels, and elevated markers of oxidative stress are a common finding among individuals with ASD. In 2008 the case of Hannah Poling was awarded compensation under the United States National Vaccine Injury Compensation Program. It was claimed that her vaccines induced a mitochondrial encephalopathy that resulted in autism. Since the mitochondria is the most significant target of thimerosal toxicity, it is particularly poignant to know that a lowering of antioxidant status by any other additional conditions such as infections or co-exposure to other toxins would further sensitize mitochondria to the damaging effects of thimerosal. These researchers state that their work, “…supports a multi-insult model of ASD causation where many individuals have the genetic background that makes them vulnerable to a particular type of insult at a particular time in their brain development…”. Just like valproate and thalidomide which are the only 2 accepted causative agents for ASD, this research has demonstrated that thimerosal is also capable of inhibiting cell proliferation.
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Fully vaccinated children require much more emergency care than undervaccinated children.
TITLE
A Population-Based Cohort Study of Undervaccination in 8 Managed Care Organizations Across the United States
CITATION
Jason M. Glanz, PhD; Sophia R. Newcomer, MPH; Komal J. Narwaney, MD, PhD; Simon J. Hambidge, MD, PhD; Matthew F. Daley, MD; Nicole M. Wagner, MPH, et al. JAMA Pediatrics, 2013;167(3):274-281.
SUMMARY
“Children who were undervaccinated because of parental choice had lower rates of outpatient visits, lower rates of ED [emergency room] encounters… undervaccinated children had lower outpatient visit rates compared with children who were age-appropriately vaccinated.”
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Infants receiving mercury-containing vaccines had much higher rates of autism than infants receiving vaccines without mercury.
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A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States
CITATION
Geier DA, Hooker BS, Kern JK, King PG, Sykes LK, Geier MR. Translational Neurodegeneration. 2013;2:25.
SUMMARY
“The present study provides new epidemiological evidence supporting an association between increasing organic-Hg [mercury] exposure from Thimerosal-containing childhood vaccines and the subsequent risk of ASD [autism] diagnosis.”
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Scientists from Mexico and Israel explain adjuvants (aluminum) used in vaccines can induce autoimmunity.
TITLE
Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum
CITATION
Vera-Lastra O, Medina G, Del-Pilar Cruz Dominguez M, Jara LJ. Expert Reviews-Clinical Immunology. 2013;9(4):361-373.
SUMMARY
Activation of the immune system by adjuvants could trigger manifestations of autoimmunity or autoimmune disease. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) includes postvaccination phenomena, macrophagic myofasciitis (MMF), Gulf War syndrome and siliconosis. Various adjuvants used in vaccines enhance a specific immune response against antigens and may produce autoimmunity and autoimmune disease in experimental models and humans. “The clinical and laboratory data support an association between adjuvants and autoimmune diseases.”
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There is a connection between infant and prenatal thimerosal exposure and neurological disorders.
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Low-dose mercury exposure in early life: Relevance of thimerosal to fetuses, newborns and infants
CITATION
Dórea JG. Current Medicinal Chemistry. 2013;20:4060-4069.
SUMMARY
This review article highlights the scientifically affirmed connection between infant and prenatal thimerosal exposure and neurological disorders, including tic disorder, which has been shown to be much more prevalent in children with autism. The author also delineates the use of thimerosal in vaccines in developing countries at a greater exposure level than developed countries such as the U.S.
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Incidences of Chicken Pox are decreasing Shingles are increasing and the costs associated with the increase in Shingles incidences have exceed the cost savings from the decrease in Chicken Pox cases.
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Review of the United States universal varicella vaccination program: Herpes zoster incidence rates, cost-effectiveness, and vaccine efficacy based primarily on the Antelope Valley Varicella Active Surveillance Project data
CITATION
G.S. Goldman and P.G. King Vaccine, 31 (2013) 1680–1694.
SUMMARY
In 2000, varicella incidence dramatically declined to 70% of the prevaccine rate but reports of Herpes zoster, Shingles, significantly increased among adults aged 20–69 years from 2000 to 2001. Even children with a prior history of varicella demonstrated Shingles rates similar to adults. By 2002, the efficacy of the varicella vaccination had declined well below 80% and the costs of the increased shingles rate have exceeded the cost savings from varicella-disease reductions.
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Danish researchers found children 8-times more likely to have a febrile seizure on the day of vaccination of DTaP-IPV-HiB vaccine.
TITLE
Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus, Acellular Pertussis, Inactivated Poliovirus, and Haemophilus Influenzae Type b
CITATION
Yuelian Sun, Jakob Christensen, Anders Hviid, Jiong Li, Et al. Journal of the Amercian Medical Association, February 22/29, 2012—Vol 307, No. 8.
SUMMARY
“DTaP-IPV-Hib vaccination was associated with an increased risk of febrile seizures on the day of the first 2 vaccinations given at 3 and 5 months.”
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Surprisingly, even though the children with the best nutritional status were vaccinated early, early DTP vaccination was associated with increased mortality.
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Early diphtheria-tetanus-pertussis vaccination associated with higher female mortality and no difference in male mortality in a cohort of low birthweight children: an observational study within a randomised trial.
CITATION
Aaby P, Ravn H, Roth A, Rodrigues A, Lisse IM, Diness BR, Lausch KR, Lund N, Rasmussen J, Biering-Sorensen S, Whittle H, Benn CS. Archives of Disease in Childhood. 2012 Aug;97(8):685-91. doi: 10.1136/archdischild-2011-300646. Epub 2012 Feb 13.
SUMMARY
Studies from low-income countries have suggested that diphtheria-tetanus-pertussis (DTP) vaccine provided after Bacille Calmette-Guerin (BCG) vaccination may have a negative effect on female survival. The authors examined the effect of DTP in a cohort of low birthweight (LBW) infants and found, surprisingly, even though the children with the best nutritional status were vaccinated early, early DTP vaccination was associated with increased mortality for girls.
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Canadian researchers review literature on autoimmunity and neurological risks from vaccine adjuvant aluminum, express doubts regarding safety testing.
TITLE
Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations
CITATION
L Tomljenovic, CA Shaw. Lupus. 2012;21:223–230.
SUMMARY
“Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In spite of the widespread agreement that vaccines are largely safe and serious adverse complications are extremely rare, a close scrutiny of the scientific literature does not support this view. For example, to date, the clinical trials that could adequately address vaccine safety issues have not been conducted (i.e., comparing health outcomes in vaccinated versus non-vaccinated children). Infants and young children should not be viewed as ‘small adults.’ Their unique physiology makes them much more vulnerable to noxious environmental insults in comparison with the adult population. In spite of this, children are routinely exposed to much higher levels of Al vaccine adjuvants than adults, even though adequate safety data on these compounds are lacking. That Al vaccine adjuvants can induce significant autoimmune conditions in humans can hardly be disputed, although still debatable is how common such side effects are. However, the existing data (or lack thereof) raise questions on whether the current vaccines aimed at pediatric populations can be accepted as having adequate safety profiles. Because infants and children represent those who may be most at risk for complications following vaccination, a more rigorous evaluation of potential vaccine-related adverse health impacts in pediatric populations than what has been provided to date is urgently needed.”
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Infants who received more vaccines had much higher hospitalization and death rates than infants who received fewer vaccines.
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Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010
CITATION
GS Goldman, NZ Miller. Human and Experimental Toxicology, 2012, 31(10) 1012–1021.
SUMMARY
“The hospitalization rate increased linearly from 11.0% (107 of 969) for 2 doses to 23.5% (661 of 2817) for 8 doses and decreased linearly from 20.1% (154 of 765) for children aged < 0.1 year to 10.7% (86 of 801) for children aged 0.9 year. Our findings show a positive correlation between the number of vaccine doses administered and the percentage of hospitalizations and deaths. Since vaccines are given to millions of infants annually, it is imperative that health authorities have scientific data from synergistic toxicity studies on all combinations of vaccines that infants might receive. Finding ways to increase vaccine safety should be the highest priority."
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Canadian researchers report vaccine aluminum and autism prevalence related.
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Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?
CITATION
Tomljenovic L, Shaw CA. Journal of Inorganic Biochemistry. 2011;105:1489-1499.
SUMMARY
“Dysfunctional immunity and impaired brain function are core deficits in ASD. Aluminum (Al), the most commonly used vaccine adjuvant, is a demonstrated neurotoxin and a strong immune stimulator. Hence, adjuvant Al has the potential to induce neuroimmune disorders. The application of the Hill’s criteria to these data indicates that the correlation between Al in vaccines and ASD may be causal. Because children represent a fraction of the population most at risk for complications following exposure to Al, a more rigorous evaluation of Al adjuvant safety seems warranted. By satisfying eight of the Hill’s criteria for establishing causality applicable to our study, we show that Al-adjuvanted vaccines may be a significant etiological factor in the rising prevalence of ASD in the Western world. We also show that children from countries with the highest ASD prevalence appear to have a much higher exposure to Al from vaccines, particularly at 2 months of age.”
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Researchers warn of sizable difference in individual reaction to vaccines, stress need to avoid increasing side effects of vaccines.
TITLE
Interindividual variations in the efficacy and toxicity of vaccines
CITATION
Chandan Thomasa, Majid Moridanib. Toxicology 278, 2010 204-210.
SUMMARY
“A number of currently available vaccines have shown significant differences in the magnitude of immune responses and toxicity in individuals undergoing vaccination. A number of factors may be involved in the variations in immune responses, which include age, gender, race, amount and quality of the antigen, the dose administered and to some extent the route of administration, and genetics of immune system. Hence, it becomes imperative that researchers have tools such as genomics and proteomics at their disposal to predict which set of population is more likely to be non-responsive or develop toxicity to vaccines.. With the increasing number of side effects associated with a number of vaccines reported over the years, it has become imperative to develop new technologies that can effectively assist in the development and evaluation of vaccines for efficacy and toxicity.”
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Scientists review literature and raise concerns about denial of environmental toxin link to autism.
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Sorting out the spinning of autism: heavy metals and the question of incidence
CITATION
DeSoto MC, Hitlan RT. ACTA Neurobiological Experimentals. 2010;70:165–176.
SUMMARY
“In this paper, we argue that increasingly over the past decade, positions that deny a link to environmental toxins and autism are based on relatively weak science and are disregarding the bulk of scientific literature. The question about toxic exposure and autism is open, with the weight of evidence favoring a connection that is not well understood. Although it is not possible to say with certainty, it seems likely that the connection would be mediated by genetic susceptibility and ability to detoxify. That is, some people have genotypes that confer higher susceptibility to toxic exposures. If so, then 50 years ago few people would have had enough toxic exposure to have the neurological changes that result in autism.”
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Baby monkeys given U.S. vaccine schedule had brain abnormalities in region responsible for social and emotional development.
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Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study
CITATION
Laura Hewitson, Brian J. Lopresti, Carol Stott, N. Scott Mason and Jaime Tomko1. ACTA Neurobiological Experimentals, 2010 70: 147–164.
SUMMARY
“The data suggest that vaccine exposure may be associated with significant disturbances in central opioidergic pathways in this model… Volumetric analyses identified significantly greater total brain volume in exposed compared with unexposed animals at both measured time points. These results raise the possibility that multiple vaccine exposures during the previous 3-4 months may have had a significant impact on brain growth and development.”
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SUNY-Stony Brook scientists find boys receiving the hepatitis B vaccine series are three times more likely to have autism.
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Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997-2002
CITATION
Gallagher C, Goodman M. Journal of Toxicology and Environmental Health, Part A. 2010;73:1665–1677.
SUMMARY
“Boys vaccinated as neonates had threefold greater odds for autism diagnosis compared to boys never vaccinated or vaccinated after the first month of life. Findings suggest that U.S. male neonates vaccinated with the hepatitis B vaccine prior to 1999 (from vaccination record) had a threefold higher risk for parental report of autism diagnosis compared to boys not vaccinated as neonates during that same time period.”
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Acellular Pertussis vaccination interferes with the optimal clearance of B. parapertussis and enhances the performance of this pathogen. Our data raise the possibility that widespread acellular Pertussis vaccination can create hosts more susceptible to B. parapertussis infection.
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Acellular pertussis vaccination facilitates Bordetella parapertussis infection in a rodent model of bordetellosis
CITATION
Gráinne H. Long, Alexia T. Karanikas, Eric T. Harvill, Andrew F. Read and Peter J. Hudson, Proceedings of the Royal Society B, Biological Sciences; 03 March, 2010; Volume 277; https://doi.org/10.1098/rspb.2010.0010
SUMMARY
Despite over 50 years of population-wide vaccination, whooping cough incidence is on the rise. Although Bordetella pertussis is considered the main causative agent of whooping cough in humans, Bordetella parapertussis infections are not uncommon. The widely used acellular whooping cough vaccines (aP) are comprised solely of B. pertussis antigens that hold little or no efficacy against B. parapertussis. Here, we ask how aP vaccination affects competitive interactions between Bordetella species within co-infected rodent hosts and thus the aP-driven strength and direction of in-host selection. We show that aP vaccination helped clear B. pertussis but resulted in an approximately 40-fold increase in B. parapertussis lung colony-forming units (CFUs). Such vaccine-mediated facilitation of B. parapertussis did not arise as a result of competitive release; B. parapertussis CFUs were higher in aP-relative to sham-vaccinated hosts regardless of whether infections were single or mixed. Further, we show that aP vaccination impedes host immunity against B. parapertussis—measured as reduced lung inflammatory and neutrophil responses. Thus, we conclude that aP vaccination interferes with the optimal clearance of B. parapertussis and enhances the performance of this pathogen. Our data raise the possibility that widespread aP vaccination can create hosts more susceptible to B. parapertussis infection.