Science Library Category:

Vaccines

Published: 2019
SYNOPSIS

French Professors demand immediate stop to Al use in vaccines and medications like antacids, as evidence shows that it poses a deadly danger to humans.

TITLE

French Professors demand immediate stop to Al use in vaccines and medications like antacids

CITATION

Gayle DeLong (2018) Journal of Toxicology and Environmental Health, Part A, 81:14, 661-674, DOI: 10.1080/15287394.2018.1477640

SUMMARY

Approximately 60% of the single women who did not receive the HPV vaccine had been pregnant at least once, whereas only 35% of women who were exposed to the vaccine had conceived. For married women, 75% who did not receive the shot were found to conceive, while only 50% who received the vaccine had ever been pregnant.

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Published: 2019
SYNOPSIS

Researchers assert that bivalent HPV vaccination in Scotland has been “highly effective” in reducing pre-malignant cervical disease, but have failed to discuss serious adverse events following HPV vaccination or other secular trends that could provide an explanation for the declines.

TITLE

Comments in response to: “Prevalence of cervical disease at age 20 after immunisation with bivalent HPV vaccine at age 12-13 in Scotland: retrospective population study.”

CITATION

Comments by Exley C, Gervas J, Selley P, Stone J, Thomas N, Vasquez A, Miller NZ, in response to: Palmer T, Wallace L, Pollock KG, et al. Prevalence of cervical disease at age 20 after immunisation with bivalent HPV vaccine at age 12-13 in Scotland: retrospective population study. BMJ. 2019;365:l1161.

SUMMARY

This collection of published comments responds to the assertion by Scottish researchers (Palmer et al., 2019) that bivalent HPV vaccination in Scotland has been “highly effective” in lowering the prevalence of pre-malignant cervical disease. The seven commenters make the following points:

  1. Exley critiques the authors’ “serious omission” in failing to discuss serious adverse events following HPV vaccination; those with “privileged access to human data” should use it “to cover all aspects of both efficacy AND safety of this vaccine.”
  2. Gervas estimates that 4,300 women would need to receive the HPV vaccine to prevent one case of severe cervical dysplasia (the “number needed to treat”).
  3. Selley describes secular trends in teen sexual behavior over the study period and asks whether the falling prevalence of pre-malignant cervical disease attributed to the HPV vaccine could be related to changes in sexual behavior.
  4. Stone calls attention to an article (Castanon and Sasieni, 2018) that reported a “dramatic increase” in England of cervical cancers in the first generation to be targeted for HPV vaccination.
  5. Thomas contests the lead author’s assertion that “In Scotland, as elsewhere, no serious adverse effects have been demonstrably linked to the [HPV] vaccine,” pointing to reports of several hundred thousand adverse events assembled by the World Health Organization (including 400 deaths) and almost 13,000 reported reactions in the UK, and observes that valid informed consent is not possible without communicating information about these risks.
  6. Vasquez points to Scotland’s public health campaign to address endemic vitamin D deficiency implemented in “close chronologic proximity” to its launch of HPV vaccination. “Crediting the reduction in HPV-related disease solely to vaccination…is potentially invalid and misleading, especially when the authors make no account whatsoever of the national program for vitamin D supplementation which started in the same timeframe.”
  7. Miller points out that the Palmer et al. study only included 12- and 13-year-old girls and “did not include older teens and women who are sexually active, have been exposed to HPV prior to HPV-vaccination, and are likely to have significantly worse outcomes than unvaccinated females.”

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Published: 2019
SYNOPSIS

This case report describes bilateral deafness following influenza vaccination.

TITLE

Bilateral deafness two days following influenza vaccination: a case report

CITATION

Kolarov C, Lobermann M, Fritsche C, Hemmer C, Mlynski R, Reisinger EC.  Human Vaccines & Immunotherapeutics. 2019;15(1):107-108.

SUMMARY

This case report describes bilateral deafness following influenza vaccination in a 79-year-old woman with previously normal hearing.

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Published: 2019
SYNOPSIS

Waning levels of measles antibodies with increasing time post-vaccination suggests that measles susceptibility is potentially increasing in Korea.

TITLE

An increasing, potentially measles-susceptible population over time after vaccination in Korea

CITATION

Kang, H. J., et al. Vaccine, 35 (2017) 4126–4132.

SUMMARY

In Korea, measles occurs mainly in infants <12 months of age, who are unvaccinated. In
addition, vaccine populations, including adolescents and young adults, can become infected through importation. Thus, the question arises whether the current level of herd immunity in Korea is now insufficient for protecting against measles infection.

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Published: 2018
SYNOPSIS

In Israel in 2017, nine measles cases were identified in a population with high measles vaccination coverage.

TITLE

Measles Outbreak in a Highly Vaccinated Population – Israel, July-August 2017

Citation

Avramovich E, Indenbaum V, Haber M, Amitai Z, Tsifanski E, Farjun S, Sarig A, Bracha A, Castillo K, Markovich MP, Galor I. MMWR Morbidity and Mortality Weekly Report. 2018 Oct 26;67(42):1186-1188.

Summary

On August 6, 2017, the Israeli Defense Force Public Heath Branch (IDFPHB) was notified of two suspected measles cases. IDFPHB conducted an epidemiologic investigation, which identified nine measles cases in a population with high measles vaccination coverage. All measles patients had signs and symptoms consistent with modified measles (i.e., less severe disease with milder rash, fever, or both, with or without other mild typical measles symptoms). A total of 1,392 contacts were identified, and 162 received postexposure prophylaxis (PEP) with measles-mumps-rubella (MMR) vaccine; the remaining contacts were followed for 21 days (one incubation period). No tertiary cases were identified.

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Published: 2018
SYNOPSIS

Gardasil clinical trial and post-marketing data should raise a red flag about HPV vaccine safety.

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Comment on: Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors.

CITATION

Martinez-Lavin M. Comment on: Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors. Cochrane Database of Systematic Reviews. 2018 October 1.

SUMMARY

This brief comment disputes as flawed the conclusions of a Cochrane systematic review of human papillomavirus (HPV) vaccine safety (Arbyn et al., 2018). The earlier review reported no increased risk of serious adverse events and dismissed post-HPV-vaccine deaths as a “chance occurrence.” However, other published studies show significantly more serious adverse events in (1) women who received Gardasil versus aluminum placebo and (2) women who received 9-valent Gardasil-9 versus 4-valent Gardasil. Stating that “hard statistical data must take preeminence over the expert’s opinion,” the author argues that Gardasil clinical trial and post-marketing data “should raise a red flag on HPV vaccine safety.”

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Published: 2018
SYNOPSIS

There are statistical increases in the incidence rate of autism, mental retardation , and speech disorders after thimerosal-containing DTaP vaccines in comparison with thimerosal-free DTaP vaccines.

TITLE

Vaccination and autoimmunity-‘vaccinosis’: a dangerous liaison?

CITATION

Shoenfeld Y, Aron-Maor A. Journal of Autoimmunity. 2000 Feb;14(1):1-10.

SUMMARY

An analysis of the Vaccine Adverse Events Reporting System (VAERS) database showed statistical increases in the incidence rate of autism (relative risk [RR] = 6.0), mental retardation (RR = 6.1), and speech disorders (RR = 2.2) after thimerosal-containing diphtheria, tetanus, and acellular pertussis (DTaP) vaccines in comparison with thimerosal-free DTaP vaccines.

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Published: 2018
SYNOPSIS

Indian study reveals birth dose of Hepatitis B vaccine is unnecessary.

TITLE

Evaluation of the Protection Provided by Hepatitis B Vaccination in India

CITATION

Puliyel, J., Naik, P., Puliyel, A. et al. Indian Journal of Pediatrics, (2018). https://doi.org/10.1007/s12098-017-2601-0.

SUMMARY

In India, Hepatitis B vaccination is recommended at 6 wk except for hospital-deliveries. The authors examined protection afforded by the birth dose and found that birth vaccination has no added protection when compared to the unvaccinated. Children who were fully vaccinated with or without birth dose of the hepatitis B vaccine had similar levels of protection against the infection.

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Published: 2018
SYNOPSIS

Dengue vaccine increases the risk of severe dengue in unexposed children.

TITLE

Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy

CITATION

S. Sridhar, A. Luedtke, E. Langevin, M. Zhu, et al. The New England Journal of Medicine, (2018), DOI: 10.1056/NEJMoa1800820.

SUMMARY

In efficacy trials of a tetravalent dengue vaccine, study authors found: “…in the absence of previous dengue exposure, the (Sanofi) vaccine partially mimics primary infection and increases the risk of severe dengue.” (800,000 kids were already vaccinated before they pulled the vaccine.)

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Published: 2018
SYNOPSIS

Women vaccinated for HPV have a lower probability of conceiving.

TITLE

A lowered probability of pregnancy in females in the USA aged 25–29 who received a human papillomavirus vaccine injection

CITATION

Gayle DeLong (2018) Journal of Toxicology and Environmental Health, Part A, 81:14, 661-674, DOI: 10.1080/15287394.2018.1477640

SUMMARY

Approximately 60% of the single women who did not receive the HPV vaccine had been pregnant at least once, whereas only 35% of women who were exposed to the vaccine had conceived. For married women, 75% who did not receive the shot were found to conceive, while only 50% who received the vaccine had ever been pregnant.

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Published: 2018
SYNOPSIS

The neonatal hepatitis B vaccination induced an anti-inflammatory response lasting for 4–5 weeks.

TITLE

IL-4 mediates the delayed neurobehavioral impairments induced by neonatal hepatitis B vaccination that involves the down-regulation of the IL-4 receptor in the hippocampus

CITATION

Yang XWJ, Xing Z, Zhang H, et al. Cytokine. 2018; 110:137-149.

SUMMARY

Experiments showed that IL-4 mediates the delayed neurobehavioral impairments induced by neonatal hepatitis B vaccination, which involves the permeability of neonatal blood–brain barrier and the down-regulation of IL-4 receptor. This finding suggests that clinical events concerning neonatal IL-4 over-exposure, including neonatal hepatitis B vaccination and allergic asthma in human infants, may have adverse implications for brain development and cognition.

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Published: 2018
SYNOPSIS

The evidence does not support HPV vaccine effectiveness in women in their mid- to late 20s.

TITLE

Effectiveness of catch-up human papillomavirus vaccination on incident cervical neoplasia in a US health-care setting: a population-based case-control study

CITATION

Silverberg MJ, Leyden WA, O’Lam J, et al. Effectiveness of catch-up human papillomavirus vaccination on incident cervical neoplasia in a US health-care setting: a population-based case-control study. Lancet Child and Adolescent Health. 2018;2(10):707-714.

SUMMARY

This article reports limited effectiveness of “catch-up” HPV vaccination in women in their 20s. The vaccine showed “no significant effectiveness” in women who initiated vaccination between 21-26 years of age (or who received less than the three-dose series), in line with other studies that likewise have found no evidence of “any vaccine effectiveness” in women in their mid- to late 20s. [Note: Although the study’s results “conflict” with arguments to extend HPV vaccination to women of older ages, the FDA nontheless approved Gardasil-9 for women and men between ages 27 and 45 in October 2018.]

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Published: 2018
SYNOPSIS

Data restrictions imposed by vaccine manufacturers and regulators inhibit independent researchers’ ability to conduct comprehensive and accurate assessments of HPV vaccine safety.

TITLE

Challenges of independent assessment of potential harms of HPV vaccines

CITATION

Jørgensen L, Doshi P, Gøtzsche P, Jefferson T. Challenges of independent assessment of potential harms of HPV vaccines. BMJ 2018;362:k3694.

SUMMARY

Vaccine manufacturer control over clinical study reports inhibits independent researchers’ ability to conduct comprehensive and accurate assessments of HPV vaccine safety. Researchers and regulators evaluating reports of HPV vaccine injuries often do not have access to thousands of pages of clinical study results and must rely on short journal publications. Unpublished reports are also far more likely to contain information about harms, including those that are relatively rare. After three years of efforts to obtain “all potentially eligible reports for a systematic review of HPV vaccines,” the authors had received only half “and these were incomplete and contained redactions.”

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Published: 2018
SYNOPSIS

Discrepancies in how countries define and evaluate difficult-to-diagnose vaccine complications may affect their conclusions about HPV vaccine safety.

TITLE

Discrepancies in the evaluation of the safety of the human papillomavirus vaccine

CITATION

Cervantes JL, Doan AH. Discrepancies in the evaluation of the safety of the human papillomavirus vaccine. Memórias Do Instituto Oswaldo Cruz. 2018;113(8):e180063.

SUMMARY

Discrepancies in how countries define and evaluate difficult-to-diagnose HPV vaccine complications may affect their conclusions about the vaccine’s safety. Japan and Colombia suspended their HPV vaccine recommendations after encountering a significant number of cases of complications; the fact that some cases were “rare” or “clinically undefined” did not sway their decision. There is a need for unbiased monitoring and reporting of adverse reactions to HPV vaccination “to ensure that the benefits of vaccines outweigh the risks of adverse reactions.”

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Published: 2018
SYNOPSIS

Autistic children with gastrointestinal symptoms have an imbalance in their immune response that affects behavior and quality of life.

TITLE

Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms

CITATION

Rose DR, Yang H, Serena G, Sturgeon C, Ma B, Careaga M, Hughes HK, Angkustsiri K, Rose M, Hertz-Picciotto I, Van de Water J, Hansen RL, Ravel J, Fasano A, Ashwood P. Brain, Behavior, and Immunity. 2018;70:354-368.

SUMMARY

Children with autism spectrum disorder (ASD) and concurrent gastrointestinal (GI) symptoms have a more imbalanced immune response, a more disturbed gut microbiome and worse behavioral outcomes (such as irritability, agitation, social withdrawal, lethargy, hyperactivity and noncompliance) than ASD children without GI symptoms. The study additionally looked at typically developing children with and without GI symptoms and found that ASD+GI children stood out compared to those two groups as well. Children with ASD plus GI symptoms may have a “propensity” toward leaky gut that contributes to their other symptoms and clinical outcomes.

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Published: 2018
SYNOPSIS

The pneumococcal conjugate vaccine (PCV13) offers no clinical benefits for adults, instead increasing pneumonia and hospitalization risks, particularly in vulnerable subgroups.  

TITLE

Evaluating clinical effectiveness of 13-valent pneumococcal conjugate vaccination against pneumonia among middle-aged and older adults in Catalonia: results from the EPIVAC cohort study

CITATION

Vila-Corcoles A, Ochoa-Gondar O, de Diego C, Satue E, Aragón M, Vila-Rovira A, Gomez-Bertomeu F, Margarolas R, Figuerola-Massana E, Raga X, Perez MO, Ballester F. Evaluating clinical effectiveness of 13-valent pneumococcal conjugate vaccination against pneumonia among middle-aged and older adults in Catalonia: results from the EPIVAC cohort study. BMC Infectious Diseases. 2018;18:196.

SUMMARY

This recent study conducted in over two million middle-aged and older adults in Catalonia found that individuals who received the pneumococcal conjugate vaccine (PCV13) were sicker than non-PCV13-vaccinated individuals. PCV13 vaccination was associated with an increased risk of all-cause pneumonia, an increased risk of hospitalization for pneumonia and increased case fatality for both pneumococcal pneumonia and all pneumonia. The vaccine was also associated with an increased risk of all-cause pneumonia in subgroups such as the elderly and immune-compromised. One mechanism possibly explaining the results is that the PCV13 vaccine may alter the flora in the sinuses and respiratory tract and lead to more infections with microorganisms not covered by the vaccine. The researchers’ conclusion is that PCV13 vaccination has no clinical benefit for adults.

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Published: 2018
SYNOPSIS

Vaccination can trigger a series of cascading events that disturbs the balance between “protective immunity” and “destructive inflammation.”

TITLE

Vaccines and neuroinflammation

Citation

Giannotta G, Giannotta N. International Journal of Public Health & Safety. 2018;3:3.

 

Summary

This study explores molecular mechanisms capable of explaining “post-vaccination inflammatory syndrome” and the neuroinflammation observed in children with autism. Focusing especially on vaccines (such as HPV vaccines) that contain biopersistent aluminum adjuvants, the authors describe how “continuously escalating doses of this poorly biodegradable adjuvant…may become insidiously unsafe,” especially in children who are vaccinated repeatedly or who have an immature or altered blood-brain barrier. Vaccination can trigger a series of cascading events (involving overexpression of the signaling molecules that regulate inflammation and activation of brain cells called microglia) that disturbs the balance between “protective immunity” and “destructive inflammation.”

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Published: 2018
SYNOPSIS

Economic evaluations of vaccination programs may be biased when they are industry-funded.

TITLE

Sponsorship bias in base-case values and uncertainty bounds of health economic evaluations? A systematic review of herpes zoster vaccination

Citation

Bilcke J, Verelst F, Beutels P. Sponsorship bias in base-case values and uncertainty bounds of health economic evaluations? A systematic review of herpes zoster vaccination. Medical Decision Making. 2018;38(6):730-745.

 

Summary

This study suggests that economic evaluations of vaccination programs have the potential to be biased when they are industry-funded. Industry-funded studies of shingles vaccination have reported more favorable cost-effectiveness ratios than non-industry funded studies. The authors caution researchers and decision-makers to be “aware of potential sponsorship bias” and also warn against cherry-picking, stating that evaluations “should consider all relevant data sources rather than (subjectively) selecting a subset of the available evidence.” In addition, they emphasize the importance of a “complete picture of the available evidence and uncertainty” when evaluating indicators such as disease burden and case fatality rate.

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Published: 2018
SYNOPSIS

Severe, long-term disability and even death can occur in a subset of individuals vulnerable to “HPV vaccination syndrome.”

TITLE

Autoimmunity, autonomic neuropathy, and the HPV vaccination: a vulnerable subpopulation

Citation

Schofield JR, Hendrickson JE. Clinical Pediatrics. 2018;57(5):603-606.

Summary

The authors describe the first biopsy-proven case of serious nerve damage developing within days of HPV vaccination, with an evident link between symptom onset and vaccination. The authors advocate for “increased [provider] awareness of the potential for neurological complications” resulting from HPV vaccination, particularly due to the “devastating clinical outcome of severe, long-term disability and even death of [a vulnerable subset] affected by the HPV vaccination syndrome.”

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Published: 2018
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Mercury-associated diagnoses are common among children diagnosed with pervasive developmental disorders.

TITLE

Symptoms observed in pervasive developmental disorders such as autism overlap with symptoms of mercury poisoning.

CITATION

Geier DA, Kern JK, Sykes LK, Geier MR. Metabolic Brain Disease. March 2018. doi: 10.1007/s11011-018-0211-9.

SUMMARY

Research indicates that environmental triggers are contributing to the childhood epidemics of autism and other pervasive developmental disorders (PDDs). The mercury-containing vaccine preservative thimerosal is a biologically plausible candidate to induce PDD. This study reveals that 12 symptom categories associated with mercury poisoning directly overlap with symptoms observed in children who have a PDD.

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Published: 2018
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Thimerosal contributes to the formation of abnormal proteins associated with Alzheimer’s and other diseases.

TITLE

Thimerosal changes protein conformation and increase the rate of fibrillation in physiological conditions: Spectroscopic studies using bovine serum albumin (BSA)

CITATION

Santos JCN, da Silva IM, Braga TC, de Fátima Å, Figueiredo IM, Santos JCC. Thimerosal changes protein conformation and increase the rate of fibrillation in physiological conditions: Spectroscopic studies using bovine serum albumin (BSA). International Journal of Biological Macromolecules. 2018;113:1032-1040.

SUMMARY

A series of experiments suggests that the effects of the vaccine preservative thimerosal on the structure of important protein molecules in the blood are one likely cause of thimerosal’s toxicity, contributing to the development of neurodegenerative and other diseases. Using a cow protein as a proxy to assess thimerosal’s impact on human serum albumin (a protein made by the liver), the study found that thimerosal accelerates the build-up of abnormal protein deposits that are associated with at least 25 diseases, including Alzheimer’s, Parkinson’s and type 2 diabetes. When bound to albumin, thimerosal also may result in “more efficient distribution” of mercury in the body.

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Published: 2017
SYNOPSIS

Mercury in the body produces a selenium deficiency state that increases toxicity.

TITLE

Rethinking mercury: the role of selenium in the pathophysiology of mercury toxicity

CITATION

Spiller HA. Rethinking mercury: the role of selenium in the pathophysiology of mercury toxicity. Clinical Toxicology. 2018;56(5):313-326.

SUMMARY

This study makes the case that mercury’s multifaceted interactions with selenium are a central feature of mercury toxicity. The authors argue that “the previously suggested ‘protective effect’ of selenium against mercury toxicity may in fact be backwards”—because of mercury’s affinity for selenium, mercury can actually produce a selenium deficiency state that promotes oxidative stress and inhibits the body’s regenerative mechanisms. Depending on the form of mercury and other factors, selenium supplementation may have some benefits for restoring adequate selenium status and mitigating the toxicity of mercury, but it does not appear to promote increased elimination of mercury.

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Published: 2017
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Adolescents given meningococcal vaccines have experienced a wide variety of serious adverse events, including new autoimmune conditions and death.

TITLE

Post-licensure safety surveillance study of routine use of quadrivalent meningococcal diphtheria toxoid conjugate vaccine

CITATION

Hansen J, Zhang L, Klein NP, et al. Vaccine 2017;35(49 Pt B):6879-84.

 

SUMMARY

Adolescents receiving the Menactra® meningococcal vaccine (MenACWY-D) in 2005-2006 experienced a variety of adverse events in the six months following vaccination—including death—but the researchers (one of whom was affilated with the vaccine’s manufacturer, Sanofi Pasteur) concluded that only two diagnoses (diabetes and juvenile rheumatoid arthritis) were “possibly related to vaccination.” After comparing 31,000 Kaiser Permanente patients who received the MenACWY-D vaccine to 31,000 matched teens who had received a tetanus-diphtheria (Td) or hepatitis vaccine the previous year, the researchers assessed 1660 outcomes and determined that 1.3% were “significantly elevated” in the meningococcal group. There were two deaths in vaccinees with cancer (“with onset preceding vaccination”) following MenACWY-D vaccination as well as a third cardiac-related death; there was also one fetal death in a young woman who received Menactra® during pregnancy. Many of the adverse events, including difficulty breathing, occurred two or more months following vaccination.

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Published: 2017
SYNOPSIS

A number of factors can predispose susceptible individuals to autoimmune reactions following vaccination.

TITLE

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

CITATION

Vadalà M, Poddighe D, Laurino C, Palmieri B. European Association for Predictive Preventive & Personalized Medicine Journal. 2017;8(3):295-311.

SUMMARY

This review discusses possible underlying mechanisms of autoimmune reactions following vaccinations and cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are possible mechanisms by which vaccines can cause autoimmune reactions. The individuals who might be susceptible to develop these reactions could be those with previous post-vaccination phenomena, those with allergies, individuals who are prone to develop autoimmune diseases (such as those with a family history of autoimmunity or with known autoantibodies) and genetically predisposed individuals.

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Published: 2017
SYNOPSIS

HPV-vaccinated women, in some settings, are less likely to get routine cervical cancer screening, which is necessary to reduce population incidence of cervical cancer.

TITLE

HPV vaccines—A review of the first decade

CITATION

Harper DM, DeMars LR. HPV vaccines—A review of the first decade. Gynecologic Oncology 2017;146(1):196-204.

SUMMARY

This mostly uncritical review of a decade of HPV vaccination draws attention to an underdiscussed aspect, which is that “[p]revention of cervical cancer must still rely on participation in ongoing screening programs.” The authors show that in many settings, HPV-vaccinated women are significantly less likely to get routine cervical cancer screening than unvaccinated women. Of concern, “the uptake of screening after the HPV vaccine introduction…has been lower than necessary to reduce population incidence of cervical cancer.” The authors comment that administering repeat doses of HPV vaccine to already vaccinated women “causes harm with no evidence of any improved prevention of HPV infections.”

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Published: 2017
SYNOPSIS

The author calls for the complete removal of thimerosal in vaccines especially in developing countries where they are used most prevalently.

TITLE

Abating Mercury Exposure in Young Children Should Include Thimerosal-Free Vaccines

CITATION

José G. Dórea. Neurochemical Research, 2017, DOI 10.1007/s11064-017-2277-x.

SUMMARY

The author of this review article contrasts the medical outcomes of children who receive thimerosal-containing vaccines versus thimerosal-free vaccines. Neurological disorders have been shown to be associated with exposure to thimerosal in vaccines. The author calls for the complete removal of thimerosal in vaccines especially in developing countries where they are used most prevalently.

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Published: 2017
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Serious adverse events observed in pre-licensure trials of Gardasil-9 cast doubts on HPV vaccine safety, but the trial investigators described the adverse events as not vaccine-related.

TITLE

Vaccine-related serious adverse events might have been under-recognized in the pivotal HPV vaccine randomized trial

Citation

Martínez-Lavín M. Vaccine-related serious adverse events might have been under-recognized in the pivotal HPV vaccine randomized trial [Letter]. Clinical Rheumatology 2017;36(4):975.

 

Summary

The largest pre-licensure trial of the Gardasil-9 vaccine—which compared Gardasil-9 against Gardasil rather than against an inert placebo—showed that Gardasil-9 had significantly more serious adverse events than Gardasil (3.3% versus 2.6%, p=0.01). However, the trial investigators judged that 0% of the serious adverse events in both groups were vaccine-related. Gardasil-9 has “more than double [the] HPV virus-like particles and aluminum adjuvant” as Gardasil. The under-recognition of serious adverse events associated with Gardasil-9 “casts further doubt on HPV vaccine safety.”

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Published: 2017
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Yale scientists find strong association between vaccinations and anorexia, ocd, and anxiety disorder.

TITLE

Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case-Control Study

CITATION

Douglas L. Leslie, Robert A. Kobre, Brian J. Richmand. Frontiers in Psychiatry, January 2017.

SUMMARY

“Subjects with newly diagnosed anorexia nervosa were more likely than controls to have had any vaccination in the previous 3 months [hazard ratio (HR) 1.80, 95% confidence interval 1.21-2.68]. Influenza vaccinations during the prior 3, 6, and 12 months were also associated with incident diagnoses of AN, OCD, and an anxiety disorder. Several other associations were also significant with HRs greater than 1.40 (hepatitis A with OCD and AN; hepatitis B with AN; and meningitis with AN and chronic tic disorder). This pilot epidemiologic analysis implies that the onset of some neuropsychiatric disorders may be temporally related to prior vaccinations in a subset of individuals.”

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Published: 2017
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Italian scientists find unexpected contaminants in all pediatric vaccines, including lead, stainless steel, tungsten, iron, and chromium

TITLE

New Quality-Control Investigations on Vaccines: Micro- and Nanocontamination

CITATION

Dr. Antonietta M. Gatti, Stefano Montanari. International Journal of Vaccines and Vaccination, January 2017.

SUMMARY

Scientists found contaminants in all vaccines that are not listed on the label of the vaccines. “The analyses carried out show that in all samples checked vaccines contain non biocompatible and bio-persistent foreign bodies which are not declared by the Producers, against which the body reacts in any case. This new investigation represents a new quality control that can be adopted to assess the safety of a vaccine. Our hypothesis is that this contamination is unintentional, since it is probably due to polluted components or procedures of industrial processes (e.g. filtrations) used to produce vaccines, not investigated and not detected by the Producers. If our hypothesis is actually the case, a close inspection of the working places and the full knowledge of the whole procedure of vaccine preparation would probably allow to eliminate the problem.”

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Published: 2016
SYNOPSIS

Israeli, Canadian and Colombian scientists show that the Gardasil vaccine triggers brain inflammation and autoimmunity in mice.

TITLE

Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil

CITATION

Inbar R, Weiss R, Tomljenovic L, Arango M-T, Deri Y, Shaw CA, Chapman J, Blank M, Shoenfeld Y. Immunologic Research. 2017;65(1):136-149.

SUMMARY

“Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine trials utilize aluminum (Al) adjuvants as placebos despite much evidence showing that Al in vaccine-relevant exposures can be toxic to humans and animals…. It appears that Gardasil via its Al adjuvant and HPV antigens has the ability to trigger neuroinflammation and autoimmune reactions, further leading to behavioral changes…. In light of these findings, this study highlights the necessity of proceeding with caution with respect to further mass-immunization practices with a vaccine of yet unproven long-term clinical benefit in cervical cancer prevention.”

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