Science Library Category:

Vaccines

Published: 2016
SYNOPSIS

Infants vaccinated with multiple vaccines at once have much higher hospitalizations and death rates than infants who receive fewer simultaneous vaccines

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Combining Childhood Vaccines at One Visit Is Not Safe

CITATION

Neil Z. Miller. Journal of American Physicians and Surgeons, Summer 2016.

SUMMARY

“Our study showed that infants who receive several vaccines concurrently, as recommended by CDC, are significantly more likely to be hospitalized or die when compared with infants who receive fewer vaccines simultaneously. It also showed that reported adverse effects were more likely to lead to hospitalization or death in younger infants. The safety of CDC’s childhood vaccination schedule was never affirmed in clinical studies. Vaccines are administered to millions of infants every year, yet health authorities have no scientific data from synergistic toxicity studies on all combinations of vaccines that infants are likely to receive. National vaccination campaigns must be supported by scientific evidence.”

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Published: 2016
SYNOPSIS

When young adults fully vaccinated in childhood with two doses of measles-mumps-rubella (MMR) vaccine are given a third dose, measles antibody levels revert to near-baseline levels within a year.

TITLE

Measles virus neutralizing antibody response, cell-mediated immunity, and IgG antibody avidity before and after a third dose of measles-mumps-rubella vaccine in young adults

Citation

Fiebelkorn AP, Coleman LA, Belongia EA, et al. Measles virus neutralizing antibody response, cell-mediated immunity, and IgG antibody avidity before and after a third dose of measles-mumps-rubella vaccine in young adults. Journal of Infectious Diseases;2016;213(7):1115-23.

 

Summary

When fully vaccinated young adults who received two doses of measles-mumps-rubella (MMR) vaccine in childhood are given a third dose (MMR3), measles antibody levels revert to near-baseline levels within a year. In this study—after just one month—MMR3 failed to produce any “substantial improvements in the quality of the immune response” for 96.8% of subjects. Individuals who had low or negative vaccine-induced antibodies at baseline were more likely to remain low or negative both one month and one year after the MMR booster, suggesting that “inherent biology” influences whether individuals respond to measles vaccination. Those who received their first MMR dose before 15 months of age also had significantly lower antibody levels later in life. The CDC and FDA researchers conclude that “MMR3 is unlikely to solve the problem of waning immunity in the U.S.”

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Published: 2016
SYNOPSIS

Israeli and Italian scientists warn that vaccine adjuvants (aluminum) are causing a wide-range of autoimmune conditions, including Sjogren’s Syndrome.

TITLE

Autoimmune/inflammatory syndrome induced by adjuvants and Sjogren’s syndrome

CITATION

Colafrancesco S, Perricone C, Shoenfeld Y. The Israel Medical Association Journal. 2016;18(3-4):150-153.

SUMMARY

Considerable evidence raises the possibility of vaccine-triggered autoimmunity. For example, case reports suggest that both vaccines and silicone may trigger the development of Sjogren’s syndrome (a chronic systemic autoimmune inflammatory condition involving the exocrine glands). Aluminum, one of the principal adjuvants used in vaccine formulation, may be responsible for the development of autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Aluminum salts seem to induce the activation of dendritic cells and complement components and increase the level of chemokine secretion at the injection site. Evidence also suggests that several vaccines, including BCG (tuberculosis), hepatitis A and/or B and human papillomavirus (HPV), should be avoided or considered only in selected individuals.

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Published: 2016
SYNOPSIS

Aluminum in vaccines is highly neurotoxic and exposure levels given to infants have dramatically increased.

TITLE

Aluminum in Childhood Vaccines Is Unsafe

CITATION

Neil Z. Miller. Journal of American Physicians and Surgeons, Winter 2016.

SUMMARY

“Infants and young children throughout the world receive high quantities of aluminum from multiple inoculations. Incremental changes to the vaccination schedule during the past several years significantly increased the quantity of aluminum in childhood shots. Numerous studies provide compelling evidence that injected aluminum can be detrimental to health. Aluminum is capable of remaining in cells long after vaccination and may cause neurologic and autoimmune disorders. During early development, the child’s brain is more susceptible to toxins and the kidneys are less able to eliminate them. Thus, children have a greater risk than adults of adverse reactions to aluminum in vaccines. Millions of children every year are injected with vaccines containing mercury and aluminum despite well-established experimental evidence of the potential for additive or synergistic toxicity when an organism is exposed to two or more toxic metals.”

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Published: 2016
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There is a significant increase in neurodevelopmental delays in children exposed to both Thimerosal (in vaccines) and methylmercury (in fish).

TITLE

Neurodevelopment of Amazonian children exposed to ethylmercury (from Thimerosal in vaccines) and methylmercury (from fish)

CITATION

Marques RC, Abreu L, Bernardi JVE, Dórea JG. Environmental Research. 2016;149:259–265.

SUMMARY

Amazonian children exposed to high and low levels of both ethyl- and methylmercury were assessed using the Mental Developmental Index and Psychomotor Developmental Index. The researchers observed statistically significant differences in the high-exposure group at 24 months in the Mental Developmental Index. Combined exposures led to developmental delays, including the age of talking and the age of walking.

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Published: 2015
SYNOPSIS

The specific mechanism of action of each vaccine adjuvant may have different effects on the course of autoimmune conditions resulting from vaccination.

TITLE

On vaccine’s adjuvants and autoimmunity: Current evidence and future perspectives

CITATION

Pellegrino P, Clementi E, Radice S. Autoimmunity Reviews. 2015;14(10):880-888.

SUMMARY

Adjuvants in vaccines have been implicated in “Autoimmune/inflammatory Syndrome Induced by Adjuvants” (ASIA), an umbrella of clinical conditions that includes post-vaccination adverse reactions. Aluminum-based compounds, in particular, are associated with the development of vaccine adjuvant-induced autoimmune diseases, but vaccines with other adjuvants may also cause specific autoimmune adverse reactions via different pathogenic mechanisms. The specific mechanism of action of each single adjuvant may have different effects on the course of different diseases.

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Published: 2015
SYNOPSIS

Evidence points to vaccine-induced autoimmunity and adjuvant-induced autoimmunity in experimental models and human patients.

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Vaccines, adjuvants and autoimmunity

CITATION

Guimarães LE, Baker B, Perricone C, Shoenfeld Y. Pharmacological Research. 2015;100:190-209.

SUMMARY

This review of the literature assembles evidence of vaccine-induced autoimmunity and adjuvant-induced autoimmunity in both experimental models as well as human patients. Adjuvants and infectious agents may exert their immune-enhancing effects through various functional activities, encompassed by the adjuvant effect. These mechanisms are shared by different conditions triggered by adjuvants leading to the autoimmune/inflammatory syndrome induced by adjuvants (ASIA).

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Published: 2015
SYNOPSIS

There is evidence of a significant relationship between increasing organic mercury exposure from Thimerosal-containing vaccines and the subsequent risk of PDD diagnosis in males and females.

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A Case-Control Study Evaluating the Relationship Between Thimerosal-Containing Haemophilus influenzae Type b Vaccine Administration and the Risk for a Pervasive Developmental Disorder Diagnosis in the United States

CITATION

David A. Geier & Janet K. Kern & Paul G. King & Lisa K. Sykes & Mark R. Geier; Biological Trace Element Research, (2015) 163:28–38.

SUMMARY

In this case-control study of pervasive development disorder (PDD) in U.S. children, cases were consistently exposed to higher levels of thimerosal via infant vaccines at both 6 months of age and 15 months of age, based specifically on Haemophilus influenzae type b vaccines. Differences between exposures in cases and controls were statistically significant at both ages evaluated.

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Published: 2015
SYNOPSIS

Some individuals are at risk of developing autoimmune/inflammatory syndrome induced by adjuvants (ASIA).

TITLE

Predicting post-vaccination autoimmunity: who might be at risk?

CITATION

Soriano A, Nesher G, Shoenfeld Y. Pharmacological Research, 2015;92:18-22. Epub 2014 Sep 30.

SUMMARY

It has been postulated that autoimmunity could be triggered or enhanced by a vaccine’s immunogen contents, as well as by adjuvants, which are used to increase the immune reaction to the immunogen. Fortunately, vaccination-related ASIA (autoimmune/inflammatory syndrome induced by adjuvants) is uncommon. Yet, by defining individuals at risk, it may be possible to further limit the number of individuals developing post-vaccination ASIA.

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Published: 2015
SYNOPSIS

Vaccines are implicated in the epidemic of childhood food allergies.

TITLE

Evidence that food proteins in vaccines cause the development of food allergies and its implications for vaccine policy

CITATION

Arumugham V. Journal of Developing Drugs. 2015;4:137.

SUMMARY

Studies, including by the Institute of Medicine, have demonstrated that food proteins contained in vaccines/injections can induce food allergy. Allergen quantities in vaccines are unregulated. C-section births bias a newborn’s immune system toward IgE synthesis due to the development of a suboptimal gut microbiome. Vaccines contain adjuvants such as aluminum compounds and pertussis toxin that also bias toward IgE synthesis. Over several decades, C-section birth rates have gone up 50%, and the vaccine schedule has increased the number of vaccine shots, with up to five vaccines administered simultaneously. “Given these conditions, the predictable and observed outcome is a food allergy epidemic.”

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Published: 2014
SYNOPSIS

FDA’s instruction to health providers that “there is no biologically plausible way in which HPV vaccine could cause infertility” is not science-based and compromises safety monitoring by undermining reporting efficiency, safety signaling and informed consent.

TITLE

Adolescent premature ovarian insufficiency following human papillomavirus vaccination: A case series seen in general practice

CITATION

Little DT, Ward HR. Journal of Investigative Medicine-High Impact Case Reports. 2014;2(4):2324709614556129.

SUMMARY

Published case reports point to a possible link between quadrivalent human papillomavirus (HPV) vaccine and premature ovarian failure. Declining menstrual function in girls aged 14, 15, and 20 years followed quadrivalent HPV vaccination and preceded premature ovarian failure. However, long-term follow-up after HPV vaccination has not surveyed ovarian function, nor recorded, measured or analyzed symptoms or signs of dysfunction. Disparagement of adverse event reporting by licensing bodies, which instruct health providers that “there is no biologically plausible way in which HPV vaccine could cause infertility,” is not science-based and compromises safety monitoring by undermining “reporting efficiency,” safety signaling and informed consent. In the absence of sound research, public reassurance that “studies have not found ovarian failure to be associated with HPV vaccination” may be harmful to vaccine confidence.

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Published: 2014
SYNOPSIS

Neurodevelopmental disorders are much more common in children who received mercury-containing vaccines.

TITLE

A dose-response relationship between organic mercury exposure from thimerosal-containing vaccines and neurodevelopmental disorders

CITATION

Geier DA, Hooker BS, Kern JK, King PG, Sykes LK, Geier MR. International Journal of Environmental Research and Public Health. 2014;11:9156-9170.

SUMMARY

On a per microgram of organic-mercury (Hg) basis, pervasive developmental disorder, specific developmental disorder, tic disorder and hyperkinetic syndrome of childhood cases were significantly more likely than controls to receive increased organic-Hg exposure. This study provides new epidemiological evidence supporting a significant relationship between increasing organic-Hg exposure from vaccines and the subsequent risk of a neurodevelopmental disorder diagnosis.

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Published: 2014
SYNOPSIS

Chinese scientists find mice injected with thimerosal (vaccine mercury) have behavioral impairments similar to autism.

TITLE

Transcriptomic analyses of neurotoxic effects in mouse brain after intermittent neonatal administration of thimerosal

CITATION

Li X, Qu F, Xie W, et al. Toxicological Sciences. 2014;139:452–465.

SUMMARY

“Thimerosal-treated mice exhibited neural development delay, social interaction deficiency, and inclination of depression. Apparent neuropathological changes were also observed in adult mice neonatally treated with thimerosal. High-throughput RNA sequencing of autistic-behaved mice brains revealed the alternation of a number of canonical pathways involving neuronal development, neuronal synaptic function, and the dysregulation of endocrine system.”

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Published: 2014
SYNOPSIS

Newborns have been overexposed to aluminum.

TITLE

Aluminum exposure and toxicity in neonates: a practical guide to halt aluminum overload in the prenatal and perinatal periods.

CITATION

Fanni D, et al. World Journal of Pediatrics, 2014 May; 10(2):101-7.

SUMMARY

During the last years, human newborns have been overexposed to biologically reactive aluminum, with possible relevant consequences on their future health and on their susceptibility to a variety of diseases. Children, newborns and particularly preterm neonates are at an increased risk of aluminum toxicity because of their relative immaturity. Based on recent original publications and classical data of the literatures, we reviewed the aluminum content in mother’s food during the intrauterine life as well as in breast milk and infant formula during lactation. We also determined the possible role of aluminum parenteral nutrition solutions, in adjuvants of vaccines and in pharmaceutical products.

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Published: 2014
SYNOPSIS

These data provide a plausible explanation for pertussis resurgence and suggest that attaining herd immunity will require the development of improved vaccination strategies that prevent B. pertussis colonization and transmission.

TITLE

Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model

CITATION

Jason M. Warfel, Lindsey I. Zimmerman, and Tod J. Merkel; Proceedings of the National Academy of Sciences; January 14, 2014, 111 (2), 787-792; https://doi.org/10.1073/pnas.1314688110.

SUMMARY

In this study, researchers found that current acellular pertussis (aP) vaccines fail to prevent colonization and transmission. Nonhuman primates vaccinated with current acellular Pertussis (aP) were protected from severe symptoms but not infection and readily transmitted Bordetella pertussis to contacts.

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Published: 2014
SYNOPSIS

UC-Boulder professor says the autism epidemic is real and therefore must be the product of an environmental factor.

TITLE

A comparison of temporal trends in United States autism prevalence to trends in suspected environmental factors

CITATION

Nevison CD. Environmental Health. 2014;13:73.

SUMMARY

“Diagnosed autism prevalence has risen dramatically in the U.S over the last several decades and continued to trend upward as of birth year 2005. The increase is mainly real and has occurred mostly since the late 1980s. In contrast, children’s exposure to most of the top ten toxic compounds has remained flat or decreased over this same time frame. Environmental factors with increasing temporal trends can help suggest hypotheses for drivers of autism that merit further investigation.”

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Published: 2013
SYNOPSIS

Israeli and Italian researchers demonstrate that exposure to aluminum in vaccines can lead to autoimmune and brain dysfunction.

TITLE

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects

CITATION

Perricone C, Colafrancesco S, Mazor RD, Soriano A, Agmon-Levin N, Shoenfeld Y. Journal of Autoimmunity. 2013;47:1-16.

SUMMARY

Environmental factors play a critical role in the induction of autoimmunity, with an interplay between genetic susceptibility and environment. Several neurologic demyelinating diseases have been reported following vaccination, notably Guillain-Barre syndrome (GBS) and acute disseminated encephalomyelitis (ADEM) (an inflammatory disease of the central nervous system). A number of the most common vaccines appear to have some involvement with autoimmunity.

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Published: 2013
SYNOPSIS

Israeli, Italian, and Canadian researchers tie HPV vaccine to primary ovarian failure.

TITLE

Human Papilloma Virus Vaccine and Primary Ovarian Failure: Another Facet of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants

CITATION

Selena Colafrancesco, Carlo Perricone, Lucija Tomljenovic, Yehuda Shoenfeld. American Journal of Reproductive Immunology, 2013.

SUMMARY

“We documented here the evidence of the potential of the HPV vaccine to trigger a life-disabling autoimmune condition. The increasing number of similar reports of post HPV vaccine-linked autoimmunity and the uncertainty of long-term clinical benefits of HPV vaccination are a matter of public health that warrants further rigorous inquiry.”

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Published: 2013
SYNOPSIS

Following implementation of changes in a pediatric medical practice to address autism risks, no new cases of autism occurred.

TITLE

Can awareness of medical pathophysiology in autism lead to primary care autism prevention strategies?

Citation

Mumper E. North American Journal of Medicine and Science. 2013;6:134-144.

 

Summary

In 2005, the author’s pediatric practice implemented seven changes to address autism risks, focusing on minimizing environmental toxicant exposure, encouraging prolonged breastfeeding, recommending probiotics, providing nutritional counseling, limiting use of antibiotics and acetaminophen and allowing a modified vaccine schedule. No new cases of autism occurred in children born between 2005 and 2011, even though the CDC autism rate would have predicted about six new cases in the practice over that period. The author cautions that “epidemiology may be too blunt a tool to determine all risks for subsets of the population who may be more vulnerable to vaccine reactions.”

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Published: 2013
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Canadian researchers: aluminum in vaccines can cause both autoimmunity and neurological damage.

TITLE

Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity

CITATION

Shaw C, Tomljenovic L. Immunologic Research. 2013;56:304–316.

SUMMARY

“In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome. Aluminum is added to vaccines to help the vaccine work more effectively, but unlike dietary aluminum which will usually clear rapidly from the body, aluminum used in vaccines and injected is designed to provide a long-lasting cellular exposure. Thus, the problem with vaccine-derived aluminum is really twofold: It drives the immune response even in the absence of a viral or bacterial threat and it can make its way into the central nervous system. It is not really a matter of much debate that aluminum in various forms can be neurotoxic.”

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Published: 2013
SYNOPSIS

Fully vaccinated children require much more emergency care than undervaccinated children.

TITLE

A Population-Based Cohort Study of Undervaccination in 8 Managed Care Organizations Across the United States

CITATION

Jason M. Glanz, PhD; Sophia R. Newcomer, MPH; Komal J. Narwaney, MD, PhD; Simon J. Hambidge, MD, PhD; Matthew F. Daley, MD; Nicole M. Wagner, MPH, et al. JAMA Pediatrics, 2013;167(3):274-281.

SUMMARY

“Children who were undervaccinated because of parental choice had lower rates of outpatient visits, lower rates of ED [emergency room] encounters… undervaccinated children had lower outpatient visit rates compared with children who were age-appropriately vaccinated.”

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Published: 2013
SYNOPSIS

Infants receiving mercury-containing vaccines had much higher rates of autism than infants receiving vaccines without mercury.

TITLE

A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States

CITATION

Geier DA, Hooker BS, Kern JK, King PG, Sykes LK, Geier MR. Translational Neurodegeneration. 2013;2:25.

SUMMARY

“The present study provides new epidemiological evidence supporting an association between increasing organic-Hg [mercury] exposure from Thimerosal-containing childhood vaccines and the subsequent risk of ASD [autism] diagnosis.”

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Published: 2013
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Scientists from Mexico and Israel explain adjuvants (aluminum) used in vaccines can induce autoimmunity.

TITLE

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum

CITATION

Vera-Lastra O, Medina G, Del-Pilar Cruz Dominguez M, Jara LJ. Expert Reviews-Clinical Immunology. 2013;9(4):361-373.

SUMMARY

Activation of the immune system by adjuvants could trigger manifestations of autoimmunity or autoimmune disease. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) includes postvaccination phenomena, macrophagic myofasciitis (MMF), Gulf War syndrome and siliconosis. Various adjuvants used in vaccines enhance a specific immune response against antigens and may produce autoimmunity and autoimmune disease in experimental models and humans. “The clinical and laboratory data support an association between adjuvants and autoimmune diseases.”

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Published: 2013
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There is a connection between infant and prenatal thimerosal exposure and neurological disorders.

TITLE

Low-dose mercury exposure in early life: Relevance of thimerosal to fetuses, newborns and infants

CITATION

Dórea JG. Current Medicinal Chemistry. 2013;20:4060-4069.

SUMMARY

This review article highlights the scientifically affirmed connection between infant and prenatal thimerosal exposure and neurological disorders, including tic disorder, which has been shown to be much more prevalent in children with autism. The author also delineates the use of thimerosal in vaccines in developing countries at a greater exposure level than developed countries such as the U.S.

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Published: 2012
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Incidences of Chicken Pox are decreasing Shingles are increasing and the costs associated with the increase in Shingles incidences have exceed the cost savings from the decrease in Chicken Pox cases.

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Review of the United States universal varicella vaccination program: Herpes zoster incidence rates, cost-effectiveness, and vaccine efficacy based primarily on the Antelope Valley Varicella Active Surveillance Project data

CITATION

G.S. Goldman and P.G. King Vaccine, 31 (2013) 1680–1694.

SUMMARY

In 2000, varicella incidence dramatically declined to 70% of the prevaccine rate but reports of Herpes zoster, Shingles, significantly increased among adults aged 20–69 years from 2000 to 2001. Even children with a prior history of varicella demonstrated Shingles rates similar to adults. By 2002, the efficacy of the varicella vaccination had declined well below 80% and the costs of the increased shingles rate have exceeded the cost savings from varicella-disease reductions.

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Published: 2012
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Danish researchers found children 8-times more likely to have a febrile seizure on the day of vaccination of DTaP-IPV-HiB vaccine.

TITLE

Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus, Acellular Pertussis, Inactivated Poliovirus, and Haemophilus Influenzae Type b

CITATION

Yuelian Sun, Jakob Christensen, Anders Hviid, Jiong Li, Et al. Journal of the Amercian Medical Association, February 22/29, 2012—Vol 307, No. 8.

SUMMARY

“DTaP-IPV-Hib vaccination was associated with an increased risk of febrile seizures on the day of the first 2 vaccinations given at 3 and 5 months.”

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Published: 2012
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Canadian researchers review literature on autoimmunity and neurological risks from vaccine adjuvant aluminum, express doubts regarding safety testing.

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Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations

CITATION

L Tomljenovic, CA Shaw. Lupus. 2012;21:223–230.

SUMMARY

“Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In spite of the widespread agreement that vaccines are largely safe and serious adverse complications are extremely rare, a close scrutiny of the scientific literature does not support this view. For example, to date, the clinical trials that could adequately address vaccine safety issues have not been conducted (i.e., comparing health outcomes in vaccinated versus non-vaccinated children). Infants and young children should not be viewed as ‘small adults.’ Their unique physiology makes them much more vulnerable to noxious environmental insults in comparison with the adult population. In spite of this, children are routinely exposed to much higher levels of Al vaccine adjuvants than adults, even though adequate safety data on these compounds are lacking. That Al vaccine adjuvants can induce significant autoimmune conditions in humans can hardly be disputed, although still debatable is how common such side effects are. However, the existing data (or lack thereof) raise questions on whether the current vaccines aimed at pediatric populations can be accepted as having adequate safety profiles. Because infants and children represent those who may be most at risk for complications following vaccination, a more rigorous evaluation of potential vaccine-related adverse health impacts in pediatric populations than what has been provided to date is urgently needed.”

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Published: 2012
SYNOPSIS

Infants who received more vaccines had much higher hospitalization and death rates than infants who received fewer vaccines.

TITLE

Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010

CITATION

GS Goldman, NZ Miller. Human and Experimental Toxicology, 2012, 31(10) 1012–1021.

SUMMARY

“The hospitalization rate increased linearly from 11.0% (107 of 969) for 2 doses to 23.5% (661 of 2817) for 8 doses and decreased linearly from 20.1% (154 of 765) for children aged < 0.1 year to 10.7% (86 of 801) for children aged 0.9 year. Our findings show a positive correlation between the number of vaccine doses administered and the percentage of hospitalizations and deaths. Since vaccines are given to millions of infants annually, it is imperative that health authorities have scientific data from synergistic toxicity studies on all combinations of vaccines that infants might receive. Finding ways to increase vaccine safety should be the highest priority."

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Published: 2011
SYNOPSIS

Canadian researchers report vaccine aluminum and autism prevalence related.

TITLE

Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?

CITATION

Tomljenovic L, Shaw CA. Journal of Inorganic Biochemistry. 2011;105:1489-1499.

SUMMARY

“Dysfunctional immunity and impaired brain function are core deficits in ASD. Aluminum (Al), the most commonly used vaccine adjuvant, is a demonstrated neurotoxin and a strong immune stimulator. Hence, adjuvant Al has the potential to induce neuroimmune disorders. The application of the Hill’s criteria to these data indicates that the correlation between Al in vaccines and ASD may be causal. Because children represent a fraction of the population most at risk for complications following exposure to Al, a more rigorous evaluation of Al adjuvant safety seems warranted. By satisfying eight of the Hill’s criteria for establishing causality applicable to our study, we show that Al-adjuvanted vaccines may be a significant etiological factor in the rising prevalence of ASD in the Western world. We also show that children from countries with the highest ASD prevalence appear to have a much higher exposure to Al from vaccines, particularly at 2 months of age.”

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Published: 2010
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Researchers warn of sizable difference in individual reaction to vaccines, stress need to avoid increasing side effects of vaccines.

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Interindividual variations in the efficacy and toxicity of vaccines

CITATION

Chandan Thomasa, Majid Moridanib. Toxicology 278, 2010 204-210.

SUMMARY

“A number of currently available vaccines have shown significant differences in the magnitude of immune responses and toxicity in individuals undergoing vaccination. A number of factors may be involved in the variations in immune responses, which include age, gender, race, amount and quality of the antigen, the dose administered and to some extent the route of administration, and genetics of immune system. Hence, it becomes imperative that researchers have tools such as genomics and proteomics at their disposal to predict which set of population is more likely to be non-responsive or develop toxicity to vaccines.. With the increasing number of side effects associated with a number of vaccines reported over the years, it has become imperative to develop new technologies that can effectively assist in the development and evaluation of vaccines for efficacy and toxicity.”

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