Science Library Category:

Diseases/Outcomes

Published: 2018
SYNOPSIS

The contamination of vaccines with animal proteins that resemble human proteins can trigger autoimmunity.

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Cancer immunology, bioinformatics and chemokine evidence link vaccines contaminated with animal proteins to autoimmune disease: a detailed look at Crohn’s disease and Vitiligo

Citation

Arumugham V, Trushin MV.  Journal of Pharmaceutical Sciences and Research. 2018;10(8):2106-2110.

Summary

Vaccines are contaminated with animal proteins that resemble human proteins, and this can result in autoimmunity. This study, which used bioinformatics to analyze animal proteins in vaccines and their similarity to human proteins, adds to growing evidence of vaccines inducing autoimmune diseases such as type 1 diabetes, Crohn’s disease, vitiligo, systemic lupus erythematosus and rheumatoid arthritis. The authors suggest that the live viruses and aluminum adjuvants in certain vaccines can stimulate the activation of particular T cells that, upon activation, may cause autoimmune disease. Because autoimmune reactions vary from person to person, “not everyone will develop overt disease”; thus, autoimmune illness may represent the tip of a broader “iceberg” of subclinical effects.

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Published: 2018
SYNOPSIS

Severe, long-term disability and even death can occur in a subset of individuals vulnerable to “HPV vaccination syndrome.”

TITLE

Autoimmunity, autonomic neuropathy, and the HPV vaccination: a vulnerable subpopulation

Citation

Schofield JR, Hendrickson JE. Clinical Pediatrics. 2018;57(5):603-606.

Summary

The authors describe the first biopsy-proven case of serious nerve damage developing within days of HPV vaccination, with an evident link between symptom onset and vaccination. The authors advocate for “increased [provider] awareness of the potential for neurological complications” resulting from HPV vaccination, particularly due to the “devastating clinical outcome of severe, long-term disability and even death of [a vulnerable subset] affected by the HPV vaccination syndrome.”

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Published: 2018
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Aluminum and mercury sulfates may contribute to neurodegeneration and progressive age-related functional decline such as Alzheimer’s disease.

TITLE

Synergism in aluminum and mercury neurotoxicity

CITATION

Alexandrov PN, Pogue AI, Lukiw WJ. Integrative Food, Nutrition and Metabolism. 2018;5(3):1-7. doi: 10.15761/IFNM.1000214.

SUMMARY

The authors analyzed the effects of aluminum and/or mercury, either alone or together, on their ability to induce inflammatory signaling in human cells and in a cell culture that is the same brain cell types targeted by the inflammatory neurodegeneration that characterizes Alzheimer’s disease. They report that neurotoxic metal sulfates obtainable via our environment or diet are significantly potent.

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Published: 2018
SYNOPSIS

Mercury-associated diagnoses are common among children diagnosed with pervasive developmental disorders.

TITLE

Symptoms observed in pervasive developmental disorders such as autism overlap with symptoms of mercury poisoning.

CITATION

Geier DA, Kern JK, Sykes LK, Geier MR. Metabolic Brain Disease. March 2018. doi: 10.1007/s11011-018-0211-9.

SUMMARY

Research indicates that environmental triggers are contributing to the childhood epidemics of autism and other pervasive developmental disorders (PDDs). The mercury-containing vaccine preservative thimerosal is a biologically plausible candidate to induce PDD. This study reveals that 12 symptom categories associated with mercury poisoning directly overlap with symptoms observed in children who have a PDD.

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Published: 2017
SYNOPSIS

Adolescents given meningococcal vaccines have experienced a wide variety of serious adverse events, including new autoimmune conditions and death.

TITLE

Post-licensure safety surveillance study of routine use of quadrivalent meningococcal diphtheria toxoid conjugate vaccine

CITATION

Hansen J, Zhang L, Klein NP, et al. Vaccine 2017;35(49 Pt B):6879-84.

 

SUMMARY

Adolescents receiving the Menactra® meningococcal vaccine (MenACWY-D) in 2005-2006 experienced a variety of adverse events in the six months following vaccination—including death—but the researchers (one of whom was affilated with the vaccine’s manufacturer, Sanofi Pasteur) concluded that only two diagnoses (diabetes and juvenile rheumatoid arthritis) were “possibly related to vaccination.” After comparing 31,000 Kaiser Permanente patients who received the MenACWY-D vaccine to 31,000 matched teens who had received a tetanus-diphtheria (Td) or hepatitis vaccine the previous year, the researchers assessed 1660 outcomes and determined that 1.3% were “significantly elevated” in the meningococcal group. There were two deaths in vaccinees with cancer (“with onset preceding vaccination”) following MenACWY-D vaccination as well as a third cardiac-related death; there was also one fetal death in a young woman who received Menactra® during pregnancy. Many of the adverse events, including difficulty breathing, occurred two or more months following vaccination.

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Published: 2017
SYNOPSIS

A number of factors can predispose susceptible individuals to autoimmune reactions following vaccination.

TITLE

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

CITATION

Vadalà M, Poddighe D, Laurino C, Palmieri B. European Association for Predictive Preventive & Personalized Medicine Journal. 2017;8(3):295-311.

SUMMARY

This review discusses possible underlying mechanisms of autoimmune reactions following vaccinations and cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are possible mechanisms by which vaccines can cause autoimmune reactions. The individuals who might be susceptible to develop these reactions could be those with previous post-vaccination phenomena, those with allergies, individuals who are prone to develop autoimmune diseases (such as those with a family history of autoimmunity or with known autoantibodies) and genetically predisposed individuals.

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Published: 2017
SYNOPSIS

Vaccination of preterm infants on the same schedule as term infants increased the odds of a neurodevelopmental disorder.

TITLE

Preterm birth, vaccination and neurodevelopmental disorders: a cross-sectional study of 6- to 12-year-old vaccinated and unvaccinated children

CITATION

Mawson AR, Bhuiyan A, Jacob B, Ray BD. Journal of Translational Science. 2017;3(3):1-8.

SUMMARY

This paper explored the association between preterm birth, vaccination and neurodevelopmental disorders (NDDs), based on a secondary analysis of data from an anonymous survey of mothers. The researchers compared the birth history and health outcomes of vaccinated and unvaccinated homeschooled children 6 to 12 years of age. The results suggest clues to the epidemiology and causation of NDDs and raise questions about the safety of current vaccination practices for preterm infants.

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Published: 2017
SYNOPSIS

Vaccinated homeschooled children had a higher rate of allergies and neurodevelopmental disorders than unvaccinated homeschooled children.

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Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12-year-old U.S. children

CITATION

Mawson AR, Ray BD, Bhuiyan AR, Jacob B. Journal of Translational Science. 2017;3(3):1-12.

SUMMARY

This study aimed 1) to compare vaccinated and unvaccinated children on a broad range of health outcomes, and 2) to determine whether an association found between vaccination and neurodevelopmental disorders (NDDs), if any, remained significant after adjustment for other measured factors. Vaccination remained significantly associated with NDDs after controlling for other factors, and preterm birth coupled with vaccination was associated with an apparent synergistic increase in the odds of NDD.

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Published: 2016
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Israeli, Canadian and Colombian scientists show that the Gardasil vaccine triggers brain inflammation and autoimmunity in mice.

TITLE

Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil

CITATION

Inbar R, Weiss R, Tomljenovic L, Arango M-T, Deri Y, Shaw CA, Chapman J, Blank M, Shoenfeld Y. Immunologic Research. 2017;65(1):136-149.

SUMMARY

“Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine trials utilize aluminum (Al) adjuvants as placebos despite much evidence showing that Al in vaccine-relevant exposures can be toxic to humans and animals…. It appears that Gardasil via its Al adjuvant and HPV antigens has the ability to trigger neuroinflammation and autoimmune reactions, further leading to behavioral changes…. In light of these findings, this study highlights the necessity of proceeding with caution with respect to further mass-immunization practices with a vaccine of yet unproven long-term clinical benefit in cervical cancer prevention.”

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Published: 2016
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There is a significant increase in neurodevelopmental delays in children exposed to both Thimerosal (in vaccines) and methylmercury (in fish).

TITLE

Neurodevelopment of Amazonian children exposed to ethylmercury (from Thimerosal in vaccines) and methylmercury (from fish)

CITATION

Marques RC, Abreu L, Bernardi JVE, Dórea JG. Environmental Research. 2016;149:259–265.

SUMMARY

Amazonian children exposed to high and low levels of both ethyl- and methylmercury were assessed using the Mental Developmental Index and Psychomotor Developmental Index. The researchers observed statistically significant differences in the high-exposure group at 24 months in the Mental Developmental Index. Combined exposures led to developmental delays, including the age of talking and the age of walking.

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Published: 2016
SYNOPSIS

Mercury exposure is implicated in neuroinflammatory disorders including autism.

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The levels of blood mercury and inflammatory-related neuropeptides in the serum are correlated in children with autism spectrum disorder

CITATION

Mostafa GA, Bjørklund G, Urbina MA, Al-Ayadhi LY. Metabolic Brain Disease. 2016;31:593–599.

SUMMARY

Blood mercury levels and tachykinins (neuropeptides that cause inflammation) were correlated in children with ASD and statistically significantly higher than neurotypical control children. It has been shown that mercury exposure can elicit tachykinin formation, which has been implicated in neuroinflammatory disorders including autism.

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Published: 2015
SYNOPSIS

The specific mechanism of action of each vaccine adjuvant may have different effects on the course of autoimmune conditions resulting from vaccination.

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On vaccine’s adjuvants and autoimmunity: Current evidence and future perspectives

CITATION

Pellegrino P, Clementi E, Radice S. Autoimmunity Reviews. 2015;14(10):880-888.

SUMMARY

Adjuvants in vaccines have been implicated in “Autoimmune/inflammatory Syndrome Induced by Adjuvants” (ASIA), an umbrella of clinical conditions that includes post-vaccination adverse reactions. Aluminum-based compounds, in particular, are associated with the development of vaccine adjuvant-induced autoimmune diseases, but vaccines with other adjuvants may also cause specific autoimmune adverse reactions via different pathogenic mechanisms. The specific mechanism of action of each single adjuvant may have different effects on the course of different diseases.

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Published: 2015
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Evidence points to vaccine-induced autoimmunity and adjuvant-induced autoimmunity in experimental models and human patients.

TITLE

Vaccines, adjuvants and autoimmunity

CITATION

Guimarães LE, Baker B, Perricone C, Shoenfeld Y. Pharmacological Research. 2015;100:190-209.

SUMMARY

This review of the literature assembles evidence of vaccine-induced autoimmunity and adjuvant-induced autoimmunity in both experimental models as well as human patients. Adjuvants and infectious agents may exert their immune-enhancing effects through various functional activities, encompassed by the adjuvant effect. These mechanisms are shared by different conditions triggered by adjuvants leading to the autoimmune/inflammatory syndrome induced by adjuvants (ASIA).

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Published: 2015
SYNOPSIS

Autistic children accumulate metals at a much higher level than children who do not have a diagnosis of autism.

TITLE

Assessment of hair aluminum, lead, and mercury in a sample of autistic Egyptian children: Environmental risk factors of heavy metals in autism

CITATION

El Baz Mohamed F, Zaky EA, Bassuoni EI-Sayed A, et al. Behavioural Neurology. 2015, Article ID 545674.

SUMMARY

Researchers found the mean levels of mercury, lead and aluminum in hair of autistic patients were significantly higher than in controls. Mercury, lead and aluminum levels were positively correlated with maternal fish consumption, living near gasoline stations and the usage of aluminum pans, respectively.

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Published: 2015
SYNOPSIS

Thimerosal exposure in humans is associated with neurodevelopmental deficits even at levels currently administered in vaccines.

TITLE

Thimerosal: Clinical, epidemiologic and biochemical studies

CITATION

Geier DA, King PG, Hooker BS, Dórea JG, Kern JK, Sykes LK, Geier MR. Clinica Chimica Acta. 2015;444:212–220.

SUMMARY

This review article includes a section on numerous papers linking thimerosal exposure via infant vaccines to autism. The publication also includes a critique of studies supported or conducted by the U.S. Centers for Disease Control and Prevention (CDC) that deny any associations between exposure to thimerosal in vaccines and the subsequent development of autism. Congress has criticized the CDC for conflicts of interest related to its vaccine development activities and role in vaccine safety oversight.

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Published: 2015
SYNOPSIS

Some individuals are at risk of developing autoimmune/inflammatory syndrome induced by adjuvants (ASIA).

TITLE

Predicting post-vaccination autoimmunity: who might be at risk?

CITATION

Soriano A, Nesher G, Shoenfeld Y. Pharmacological Research, 2015;92:18-22. Epub 2014 Sep 30.

SUMMARY

It has been postulated that autoimmunity could be triggered or enhanced by a vaccine’s immunogen contents, as well as by adjuvants, which are used to increase the immune reaction to the immunogen. Fortunately, vaccination-related ASIA (autoimmune/inflammatory syndrome induced by adjuvants) is uncommon. Yet, by defining individuals at risk, it may be possible to further limit the number of individuals developing post-vaccination ASIA.

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Published: 2015
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Vaccines are implicated in the epidemic of childhood food allergies.

TITLE

Evidence that food proteins in vaccines cause the development of food allergies and its implications for vaccine policy

CITATION

Arumugham V. Journal of Developing Drugs. 2015;4:137.

SUMMARY

Studies, including by the Institute of Medicine, have demonstrated that food proteins contained in vaccines/injections can induce food allergy. Allergen quantities in vaccines are unregulated. C-section births bias a newborn’s immune system toward IgE synthesis due to the development of a suboptimal gut microbiome. Vaccines contain adjuvants such as aluminum compounds and pertussis toxin that also bias toward IgE synthesis. Over several decades, C-section birth rates have gone up 50%, and the vaccine schedule has increased the number of vaccine shots, with up to five vaccines administered simultaneously. “Given these conditions, the predictable and observed outcome is a food allergy epidemic.”

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Published: 2014
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Researchers found that febrile seizures occurred in roughly one in every 1,000 children who were given the MMR vaccine and two genetic variants came to light that pointed to a higher risk of a febrile seizure in the second week following MMR vaccination.

TITLE

Common variants associated with general and MMR vaccine–related febrile seizures

CITATION

Bjarke Feenstra, Bjorn Pasternak, Frank Geller, Lisbeth Carstensen, et. al. Nature Genetics 46, 1274-1282; 26 October, 2014.

SUMMARY

Febrile seizures represent a serious adverse event following measles, mumps and rubella (MMR) vaccination. We conducted a series of genome-wide association scans comparing children with MMR-related febrile seizures, children with febrile seizures unrelated to vaccination and controls with no history of febrile seizures. Two loci were distinctly associated with MMR-related febrile seizures. Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes and a region associated with magnesium levels.

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Published: 2014
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FDA’s instruction to health providers that “there is no biologically plausible way in which HPV vaccine could cause infertility” is not science-based and compromises safety monitoring by undermining reporting efficiency, safety signaling and informed consent.

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Adolescent premature ovarian insufficiency following human papillomavirus vaccination: A case series seen in general practice

CITATION

Little DT, Ward HR. Journal of Investigative Medicine-High Impact Case Reports. 2014;2(4):2324709614556129.

SUMMARY

Published case reports point to a possible link between quadrivalent human papillomavirus (HPV) vaccine and premature ovarian failure. Declining menstrual function in girls aged 14, 15, and 20 years followed quadrivalent HPV vaccination and preceded premature ovarian failure. However, long-term follow-up after HPV vaccination has not surveyed ovarian function, nor recorded, measured or analyzed symptoms or signs of dysfunction. Disparagement of adverse event reporting by licensing bodies, which instruct health providers that “there is no biologically plausible way in which HPV vaccine could cause infertility,” is not science-based and compromises safety monitoring by undermining “reporting efficiency,” safety signaling and informed consent. In the absence of sound research, public reassurance that “studies have not found ovarian failure to be associated with HPV vaccination” may be harmful to vaccine confidence.

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Published: 2014
SYNOPSIS

Neurodevelopmental disorders are much more common in children who received mercury-containing vaccines.

TITLE

A dose-response relationship between organic mercury exposure from thimerosal-containing vaccines and neurodevelopmental disorders

CITATION

Geier DA, Hooker BS, Kern JK, King PG, Sykes LK, Geier MR. International Journal of Environmental Research and Public Health. 2014;11:9156-9170.

SUMMARY

On a per microgram of organic-mercury (Hg) basis, pervasive developmental disorder, specific developmental disorder, tic disorder and hyperkinetic syndrome of childhood cases were significantly more likely than controls to receive increased organic-Hg exposure. This study provides new epidemiological evidence supporting a significant relationship between increasing organic-Hg exposure from vaccines and the subsequent risk of a neurodevelopmental disorder diagnosis.

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Published: 2014
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MMR vaccination nearly triples the risk of febrile seizures within two weeks of vaccination, and some children are genetically vulnerable to this serious MMR-related adverse event.

TITLE

Common variants associated with general and MMR vaccine-related febrile seizures

Citation

Feenstra B, Pasternak B, Geller F, et al. Nature Genetics 2014;46(12):1274-1282.

Summary

MMR vaccination nearly triples the risk of febrile seizures—a serious adverse event—within two weeks of vaccination. This study explored whether genetic variants might explain the increased risk by comparing children who experienced MMR-related febrile seizures to children who had “MMR-unrelated febrile seizures” as well as a control group free of seizures. The analysis identified two genetic loci “distinctly associated with febrile seizures as an adverse event follow­ing MMR vaccination”—and four more related to febrile seizures in general. The authors hypothesize a two-stage response whereby the MMR-related genetic variants induce fever and then the febrile seizure variants trigger the seizure response. They note the need for additional studies “to determine whether the variants are associated with response to other vaccines.”

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Published: 2014
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Mesenchymal stem cells may be promising candidates for addressing autism-related immune dysregulation.

TITLE

Mesenchymal stem cells in treating autism: novel insights

Citation

Siniscalco D, Bradstreet JJ, Sych N, Antonucci N. World Journal of Stem Cells. 2014;6:173-178.

 

Summary

Mesenchymal stem cells (MSCs) possess unique immunological properties that make them promising candidates in regenerative medicine, with the potential to address the immune dysregulation often observed in autism spectrum disorder (ASD). This study describes a variety of mechanisms through which MSCs could exert a positive effect in ASD.

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Published: 2014
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There has been an epidemic of inflammatory diseases that has paralleled the epidemic on iatrogenic immune stimulation with vaccines. The epidemic of diabetes/prediabetes appears to be accelerating at a time when the prevalence of obesity has stabilized, indicating that the negative feedback system of the immune system has been over whelmed.

TITLE

Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases

CITATION

Classen JB (2014) Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases. J Mol Genet Med S1: 025. doi:10.4172/1747-0862.S1-025

SUMMARY

There has been an epidemic of inflammatory diseases that has paralleled the epidemic on iatrogenic immune stimulation with vaccines. Extensive evidence links vaccine induced immune over load with the epidemic of type 1 diabetes. More recent data indicates that obesity, type 2 diabetes and other components of metabolic syndrome are highly associated with immunization and may be manifestations of the negative feedback loop of the immune system reacting to the immune overload. The epidemic of diabetes/prediabetes appears to be accelerating at a time when the prevalence of obesity has stabilized, indicating that the negative feedback system of the immune system has been over whelmed. The theory of vaccine induced immune overload can explain the key observations that have confounded many competing hypothesis. The current paper reviews the evidence that vaccine induced immune overload explains the disconnect between the increase in prediabetes and nonalcoholic fatty liver at a time when the obesity epidemic is waning in children.

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Published: 2013
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Israeli and Italian researchers demonstrate that exposure to aluminum in vaccines can lead to autoimmune and brain dysfunction.

TITLE

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects

CITATION

Perricone C, Colafrancesco S, Mazor RD, Soriano A, Agmon-Levin N, Shoenfeld Y. Journal of Autoimmunity. 2013;47:1-16.

SUMMARY

Environmental factors play a critical role in the induction of autoimmunity, with an interplay between genetic susceptibility and environment. Several neurologic demyelinating diseases have been reported following vaccination, notably Guillain-Barre syndrome (GBS) and acute disseminated encephalomyelitis (ADEM) (an inflammatory disease of the central nervous system). A number of the most common vaccines appear to have some involvement with autoimmunity.

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Published: 2013
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Canadian researchers: aluminum in vaccines can cause both autoimmunity and neurological damage.

TITLE

Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity

CITATION

Shaw C, Tomljenovic L. Immunologic Research. 2013;56:304–316.

SUMMARY

“In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome. Aluminum is added to vaccines to help the vaccine work more effectively, but unlike dietary aluminum which will usually clear rapidly from the body, aluminum used in vaccines and injected is designed to provide a long-lasting cellular exposure. Thus, the problem with vaccine-derived aluminum is really twofold: It drives the immune response even in the absence of a viral or bacterial threat and it can make its way into the central nervous system. It is not really a matter of much debate that aluminum in various forms can be neurotoxic.”

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Published: 2013
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Research has determined there is a subgroup of the population that has hypersensitivity to the toxicity of thimerosal yet thimerosal containing vaccines are administered to all without consideration to this important fact. We can ban peanuts from schools because a subpopulation is allergic to them, so why is thimerosal still contained in our vaccines?

TITLE

B-lymphocytes from a population of children with autism spectrum disorder and their unaffected siblings exhibit hypersensitivity to thimerosal.

CITATION

Sharpe MA, Gist TL, Baskin DS. J Toxicol. 2013;2013:801517. doi: 10.1155/2013/801517. Epub 2013 Jun 9.

SUMMARY

Two medications (valproate and thalidomide) have been definitively shown to be causative with regards to autism spectrum disorder (ASD). Both of these medications share a common trait of inhibiting cell proliferation. Thus, these researchers set out to determine if thimerosal can inhibit cell proliferation using doses of thimerosal which reflect the concentrations that infants are exposed to via vaccinations. The design of this experiment was chosen to be able to distinguish between shared or different in utero environments among families with an ASD member. To accomplish this goal, B-cells were collected from, ASD individuals, their unaffected fraternal twins representing a shared in utero environment, and their unaffected nontwin siblings. In the same manner, B-cells were collected from control families with no history of ASD which were matched for age/sex/ethnicity and compared to ASD families. It was determined that there is a hypersensitivity to thimerosal among a subpopulation of ASD families. The target of thimerosal toxicity is the mitochondria and cell proliferation was inhibited at a dose that was lower than that required to cause cell death.  Among the hypersensitive population, the dose of thimerosal that could inhibit cell proliferation was found to be only 40% of that needed to inhibit proliferation in the control group. Whether a twin or sibling was hypersensitive was dependent on having another family member with hypersensitivity. This finding implies there is a genetic component to thimerosal hypersensitivity. Among the ASD families with hypersensitivity oxidative stress was determined to be the contributing factor. Poor antioxidant status, high lactate levels, and elevated markers of oxidative stress are a common finding among individuals with ASD. In 2008 the case of Hannah Poling was awarded compensation under the United States National Vaccine Injury Compensation Program. It was claimed that her vaccines induced a mitochondrial encephalopathy that resulted in autism. Since the mitochondria is the most significant target of thimerosal toxicity, it is particularly poignant to know that a lowering of antioxidant status by any other additional conditions such as infections or co-exposure to other toxins would further sensitize mitochondria to the damaging effects of thimerosal. These researchers state that their work, “…supports a multi-insult model of ASD causation where many individuals have the genetic background that makes them vulnerable to a particular type of insult at a particular time in their brain development…”. Just like valproate and thalidomide which are the only 2 accepted causative agents for ASD, this research has demonstrated that thimerosal is also capable of inhibiting cell proliferation.

 

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Published: 2013
SYNOPSIS

Scientists from Mexico and Israel explain adjuvants (aluminum) used in vaccines can induce autoimmunity.

TITLE

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum

CITATION

Vera-Lastra O, Medina G, Del-Pilar Cruz Dominguez M, Jara LJ. Expert Reviews-Clinical Immunology. 2013;9(4):361-373.

SUMMARY

Activation of the immune system by adjuvants could trigger manifestations of autoimmunity or autoimmune disease. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) includes postvaccination phenomena, macrophagic myofasciitis (MMF), Gulf War syndrome and siliconosis. Various adjuvants used in vaccines enhance a specific immune response against antigens and may produce autoimmunity and autoimmune disease in experimental models and humans. “The clinical and laboratory data support an association between adjuvants and autoimmune diseases.”

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Published: 2013
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There is a connection between infant and prenatal thimerosal exposure and neurological disorders.

TITLE

Low-dose mercury exposure in early life: Relevance of thimerosal to fetuses, newborns and infants

CITATION

Dórea JG. Current Medicinal Chemistry. 2013;20:4060-4069.

SUMMARY

This review article highlights the scientifically affirmed connection between infant and prenatal thimerosal exposure and neurological disorders, including tic disorder, which has been shown to be much more prevalent in children with autism. The author also delineates the use of thimerosal in vaccines in developing countries at a greater exposure level than developed countries such as the U.S.

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Published: 2012
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Canadian researchers review literature on autoimmunity and neurological risks from vaccine adjuvant aluminum, express doubts regarding safety testing.

TITLE

Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations

CITATION

L Tomljenovic, CA Shaw. Lupus. 2012;21:223–230.

SUMMARY

“Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In spite of the widespread agreement that vaccines are largely safe and serious adverse complications are extremely rare, a close scrutiny of the scientific literature does not support this view. For example, to date, the clinical trials that could adequately address vaccine safety issues have not been conducted (i.e., comparing health outcomes in vaccinated versus non-vaccinated children). Infants and young children should not be viewed as ‘small adults.’ Their unique physiology makes them much more vulnerable to noxious environmental insults in comparison with the adult population. In spite of this, children are routinely exposed to much higher levels of Al vaccine adjuvants than adults, even though adequate safety data on these compounds are lacking. That Al vaccine adjuvants can induce significant autoimmune conditions in humans can hardly be disputed, although still debatable is how common such side effects are. However, the existing data (or lack thereof) raise questions on whether the current vaccines aimed at pediatric populations can be accepted as having adequate safety profiles. Because infants and children represent those who may be most at risk for complications following vaccination, a more rigorous evaluation of potential vaccine-related adverse health impacts in pediatric populations than what has been provided to date is urgently needed.”

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Published: 2011
SYNOPSIS

Using the Tukey-Kramer test, statistically significant differences in mean IMRs (infant mortality rates) were found between nations giving 12-14 vaccine doses and those giving 21-23, and 24-26 doses.”

TITLE

Infant mortality rates regressed against number of vaccine doses routinely given: is there a biochemical or synergistic toxicity?

CITATION

Neil Z Miller and Gary S Goldman; Human and Experimental Toxicology. 2011 Sep; 30(9): 1420–1428. doi: 10.1177/0960327111407644.

SUMMARY

The infant mortality rate (IMR) is one of the most important indicators of the socio-economic well-being and public health conditions of a country. The US childhood immunization schedule specifies 26 vaccine doses for infants aged less than 1 year—the most in the world—yet 33 nations have lower IMRs. Using linear regression, the immunization schedules of these 34 nations were examined and a correlation was found between IMRs and the number of vaccine doses routinely given to infants.

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