Science Library Category:

Diseases/Outcomes

Published: 2015
SYNOPSIS

Thimerosal exposure in humans is associated with neurodevelopmental deficits even at levels currently administered in vaccines.

TITLE

Thimerosal: Clinical, epidemiologic and biochemical studies

CITATION

Geier DA, King PG, Hooker BS, Dórea JG, Kern JK, Sykes LK, Geier MR. Clinica Chimica Acta. 2015;444:212–220.

SUMMARY

This review article includes a section on numerous papers linking thimerosal exposure via infant vaccines to autism. The publication also includes a critique of studies supported or conducted by the U.S. Centers for Disease Control and Prevention (CDC) that deny any associations between exposure to thimerosal in vaccines and the subsequent development of autism. Congress has criticized the CDC for conflicts of interest related to its vaccine development activities and role in vaccine safety oversight.

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Published: 2015
SYNOPSIS

Some individuals are at risk of developing autoimmune/inflammatory syndrome induced by adjuvants (ASIA).

TITLE

Predicting post-vaccination autoimmunity: who might be at risk?

CITATION

Soriano A, Nesher G, Shoenfeld Y. Pharmacological Research, 2015;92:18-22. Epub 2014 Sep 30.

SUMMARY

It has been postulated that autoimmunity could be triggered or enhanced by a vaccine’s immunogen contents, as well as by adjuvants, which are used to increase the immune reaction to the immunogen. Fortunately, vaccination-related ASIA (autoimmune/inflammatory syndrome induced by adjuvants) is uncommon. Yet, by defining individuals at risk, it may be possible to further limit the number of individuals developing post-vaccination ASIA.

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Published: 2015
SYNOPSIS

Vaccines are implicated in the epidemic of childhood food allergies.

TITLE

Evidence that food proteins in vaccines cause the development of food allergies and its implications for vaccine policy

CITATION

Arumugham V. Journal of Developing Drugs. 2015;4:137.

SUMMARY

Studies, including by the Institute of Medicine, have demonstrated that food proteins contained in vaccines/injections can induce food allergy. Allergen quantities in vaccines are unregulated. C-section births bias a newborn’s immune system toward IgE synthesis due to the development of a suboptimal gut microbiome. Vaccines contain adjuvants such as aluminum compounds and pertussis toxin that also bias toward IgE synthesis. Over several decades, C-section birth rates have gone up 50%, and the vaccine schedule has increased the number of vaccine shots, with up to five vaccines administered simultaneously. “Given these conditions, the predictable and observed outcome is a food allergy epidemic.”

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Published: 2014
SYNOPSIS

FDA’s instruction to health providers that “there is no biologically plausible way in which HPV vaccine could cause infertility” is not science-based and compromises safety monitoring by undermining reporting efficiency, safety signaling and informed consent.

TITLE

Adolescent premature ovarian insufficiency following human papillomavirus vaccination: A case series seen in general practice

CITATION

Little DT, Ward HR. Journal of Investigative Medicine-High Impact Case Reports. 2014;2(4):2324709614556129.

SUMMARY

Published case reports point to a possible link between quadrivalent human papillomavirus (HPV) vaccine and premature ovarian failure. Declining menstrual function in girls aged 14, 15, and 20 years followed quadrivalent HPV vaccination and preceded premature ovarian failure. However, long-term follow-up after HPV vaccination has not surveyed ovarian function, nor recorded, measured or analyzed symptoms or signs of dysfunction. Disparagement of adverse event reporting by licensing bodies, which instruct health providers that “there is no biologically plausible way in which HPV vaccine could cause infertility,” is not science-based and compromises safety monitoring by undermining “reporting efficiency,” safety signaling and informed consent. In the absence of sound research, public reassurance that “studies have not found ovarian failure to be associated with HPV vaccination” may be harmful to vaccine confidence.

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Published: 2014
SYNOPSIS

Neurodevelopmental disorders are much more common in children who received mercury-containing vaccines.

TITLE

A dose-response relationship between organic mercury exposure from thimerosal-containing vaccines and neurodevelopmental disorders

CITATION

Geier DA, Hooker BS, Kern JK, King PG, Sykes LK, Geier MR. International Journal of Environmental Research and Public Health. 2014;11:9156-9170.

SUMMARY

On a per microgram of organic-mercury (Hg) basis, pervasive developmental disorder, specific developmental disorder, tic disorder and hyperkinetic syndrome of childhood cases were significantly more likely than controls to receive increased organic-Hg exposure. This study provides new epidemiological evidence supporting a significant relationship between increasing organic-Hg exposure from vaccines and the subsequent risk of a neurodevelopmental disorder diagnosis.

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Published: 2014
SYNOPSIS

MMR vaccination nearly triples the risk of febrile seizures within two weeks of vaccination, and some children are genetically vulnerable to this serious MMR-related adverse event.

TITLE

Common variants associated with general and MMR vaccine-related febrile seizures

Citation

Feenstra B, Pasternak B, Geller F, et al. Nature Genetics 2014;46(12):1274-1282.

Summary

MMR vaccination nearly triples the risk of febrile seizures—a serious adverse event—within two weeks of vaccination. This study explored whether genetic variants might explain the increased risk by comparing children who experienced MMR-related febrile seizures to children who had “MMR-unrelated febrile seizures” as well as a control group free of seizures. The analysis identified two genetic loci “distinctly associated with febrile seizures as an adverse event follow­ing MMR vaccination”—and four more related to febrile seizures in general. The authors hypothesize a two-stage response whereby the MMR-related genetic variants induce fever and then the febrile seizure variants trigger the seizure response. They note the need for additional studies “to determine whether the variants are associated with response to other vaccines.”

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Published: 2014
SYNOPSIS

Mesenchymal stem cells may be promising candidates for addressing autism-related immune dysregulation.

TITLE

Mesenchymal stem cells in treating autism: novel insights

Citation

Siniscalco D, Bradstreet JJ, Sych N, Antonucci N. World Journal of Stem Cells. 2014;6:173-178.

 

Summary

Mesenchymal stem cells (MSCs) possess unique immunological properties that make them promising candidates in regenerative medicine, with the potential to address the immune dysregulation often observed in autism spectrum disorder (ASD). This study describes a variety of mechanisms through which MSCs could exert a positive effect in ASD.

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Published: 2013
SYNOPSIS

Israeli and Italian researchers demonstrate that exposure to aluminum in vaccines can lead to autoimmune and brain dysfunction.

TITLE

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects

CITATION

Perricone C, Colafrancesco S, Mazor RD, Soriano A, Agmon-Levin N, Shoenfeld Y. Journal of Autoimmunity. 2013;47:1-16.

SUMMARY

Environmental factors play a critical role in the induction of autoimmunity, with an interplay between genetic susceptibility and environment. Several neurologic demyelinating diseases have been reported following vaccination, notably Guillain-Barre syndrome (GBS) and acute disseminated encephalomyelitis (ADEM) (an inflammatory disease of the central nervous system). A number of the most common vaccines appear to have some involvement with autoimmunity.

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Published: 2013
SYNOPSIS

Canadian researchers: aluminum in vaccines can cause both autoimmunity and neurological damage.

TITLE

Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity

CITATION

Shaw C, Tomljenovic L. Immunologic Research. 2013;56:304–316.

SUMMARY

“In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome. Aluminum is added to vaccines to help the vaccine work more effectively, but unlike dietary aluminum which will usually clear rapidly from the body, aluminum used in vaccines and injected is designed to provide a long-lasting cellular exposure. Thus, the problem with vaccine-derived aluminum is really twofold: It drives the immune response even in the absence of a viral or bacterial threat and it can make its way into the central nervous system. It is not really a matter of much debate that aluminum in various forms can be neurotoxic.”

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Published: 2013
SYNOPSIS

Scientists from Mexico and Israel explain adjuvants (aluminum) used in vaccines can induce autoimmunity.

TITLE

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum

CITATION

Vera-Lastra O, Medina G, Del-Pilar Cruz Dominguez M, Jara LJ. Expert Reviews-Clinical Immunology. 2013;9(4):361-373.

SUMMARY

Activation of the immune system by adjuvants could trigger manifestations of autoimmunity or autoimmune disease. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) includes postvaccination phenomena, macrophagic myofasciitis (MMF), Gulf War syndrome and siliconosis. Various adjuvants used in vaccines enhance a specific immune response against antigens and may produce autoimmunity and autoimmune disease in experimental models and humans. “The clinical and laboratory data support an association between adjuvants and autoimmune diseases.”

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Published: 2013
SYNOPSIS

There is a connection between infant and prenatal thimerosal exposure and neurological disorders.

TITLE

Low-dose mercury exposure in early life: Relevance of thimerosal to fetuses, newborns and infants

CITATION

Dórea JG. Current Medicinal Chemistry. 2013;20:4060-4069.

SUMMARY

This review article highlights the scientifically affirmed connection between infant and prenatal thimerosal exposure and neurological disorders, including tic disorder, which has been shown to be much more prevalent in children with autism. The author also delineates the use of thimerosal in vaccines in developing countries at a greater exposure level than developed countries such as the U.S.

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Published: 2012
SYNOPSIS

Canadian researchers review literature on autoimmunity and neurological risks from vaccine adjuvant aluminum, express doubts regarding safety testing.

TITLE

Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations

CITATION

L Tomljenovic, CA Shaw. Lupus. 2012;21:223–230.

SUMMARY

“Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In spite of the widespread agreement that vaccines are largely safe and serious adverse complications are extremely rare, a close scrutiny of the scientific literature does not support this view. For example, to date, the clinical trials that could adequately address vaccine safety issues have not been conducted (i.e., comparing health outcomes in vaccinated versus non-vaccinated children). Infants and young children should not be viewed as ‘small adults.’ Their unique physiology makes them much more vulnerable to noxious environmental insults in comparison with the adult population. In spite of this, children are routinely exposed to much higher levels of Al vaccine adjuvants than adults, even though adequate safety data on these compounds are lacking. That Al vaccine adjuvants can induce significant autoimmune conditions in humans can hardly be disputed, although still debatable is how common such side effects are. However, the existing data (or lack thereof) raise questions on whether the current vaccines aimed at pediatric populations can be accepted as having adequate safety profiles. Because infants and children represent those who may be most at risk for complications following vaccination, a more rigorous evaluation of potential vaccine-related adverse health impacts in pediatric populations than what has been provided to date is urgently needed.”

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Published: 2010
SYNOPSIS

It is feasible that vaccinations may contribute to the mosaic of autoimmunity.

TITLE

Vaccines and autoimmune diseases of the adult

CITATION

Orbach H, Agmon-Levin N, Zandman-Goddard G. Discovery Medicine. 2014;10(2):101-107.

SUMMARY

Infectious agents contribute to the environmental factors involved in the development of autoimmune diseases possibly through molecular mimicry mechanisms. Hence, it is feasible that vaccinations may also contribute to the mosaic of autoimmunity. Evidence for the association of vaccinations and the development of these diseases is presented in this review.

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Published: 2009
SYNOPSIS

Swedish researchers found that children who had natural measles infection had much lower rates of allergy than children vaccinated against measles.

TITLE

Allergic disease and atopic sensitization in children in relation to measles vaccination and measles infection

CITATION

Rosenlund H, Bergstrom A, Alm JS, … PARSIFAL Study Group. Pediatrics. 2009;123(3):771-778.

SUMMARY

In these analyses, measles infection [natural measles] was inversely associated with any allergic symptom or physician’s diagnosis of allergy, suggesting that natural measles infection may protect against allergies in children.

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Published: 2008
SYNOPSIS

Boys receiving the hepatitis B vaccine series were nine times more likely to need special education and be developmentally disabled.

TITLE

Hepatitis B triple series vaccine and developmental disability in US children aged 1-9 years

CITATION

Gallagher C, Goodman M. Toxicological and Environmental Chemistry. 2008;90(5):997-1008.

SUMMARY

This study investigated the association between vaccination with the hepatitis B triple series vaccine (pre-2000) and subsequent developmental disability. The odds of receiving special education were approximately nine times as great for vaccinated boys as for unvaccinated boys, after adjustment for confounders. The evidence, statistically significant, suggests that boys in United States who were vaccinated with the triple series hepatitis B vaccine were more susceptible to developmental disability than were unvaccinated boys.

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Published: 2008
SYNOPSIS

A CDC-sponsored database showed much higher rates of neurodevelopmental disabilities from mercury-containing vaccines.

TITLE

Thimerosal exposure in infants and neurodevelopmental disorders: An assessment of computerized medical records in the Vaccine Safety Datalink

CITATION

Young HA, Geier DA, Geier MR. Journal of the Neurological Sciences. 2008;121:626-631.

SUMMARY

“Consistent significantly increased rate ratios were observed for autism, autism spectrum disorders, tics, attention deficit disorder, and emotional disturbances with Hg [mercury] exposure from TCVs [thimerosal-containing vaccines]. By contrast, none of the control outcomes had significantly increased rate ratios with Hg exposure from TCVs.”

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Published: 2008
SYNOPSIS

Children who delayed the timing of the DPT vaccine had lower rates of asthma.

TITLE

Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma?

CITATION

McDonald KL, Huq SI. Journal of the American Academy of Allergy, Asthma and Immunology. 2008;121:626-631.

SUMMARY

“Early childhood immunizations have been viewed as promoters of asthma development by stimulating a T(H)2-type immune response or decreasing microbial pressure, which shifts the balance between T(H)1 and T(H)2 immunity. Among 11, 531 children who received at least 4 doses of DPT, the risk of asthma was reduced to (1/2) in children whose first dose of DPT was delayed by more than 2 months.”

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Published: 2007
SYNOPSIS

Neonatal deaths following hepatitis B vaccination should be investigated as possible vaccine-related deaths.

TITLE

An investigation of infant deaths following initial hepatitis B vaccination based on the Vaccine Adverse Event Reporting System (VAERS), 1992-2002

CITATION

Soldatenkova VA, Yazbak FE. Medical Veritas. 2007;4:1414-1421.

SUMMARY

This study argues that all unexpected neonatal deaths occurring after initial hepatitis B vaccination should be systematically investigated. Over one-fifth (22%) of neonatal hepatitis B vaccine injuries reported to the U.S. Vaccine Adverse Event Reporting System (VAERS) from 1992 to 2002 were deaths (38/170) that, in nearly all cases, occurred within hours or days of vaccination. Although most of the deaths were officially classified as sudden infant death syndrome (SIDS) or “unexplained” rather than as vaccine-related deaths, the authors note “a statistically significant increase in [the] proportion of neonatal SIDS since implementation of universal vaccination of newborns against hepatitis B.” The VAERS reports also are suggestive of higher risks for premature, small, or slightly ill infants.

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Published: 2007
SYNOPSIS

Test scores among young men declined between 1998 and 2003/04.

TITLE

Secular declines in cognitive test scores: A reversal of the Flynn Effect

CITATION

Teasdale TW, Owen DR. Intelligence. 2008;36:121–126.

SUMMARY

Scores on cognitive tests have been very widely reported to have increased through the decades of the last century, a generational phenomenon termed the “Flynn Effect” since it was comprehensively documented by James Flynn in the 1980s. Data reported here from young adult males in Denmark show that whereas there were modest increases between 1988 and 1998, scores on all four tests declined between 1998 and 2003/2004.

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Published: 2005
SYNOPSIS

Many heavy metals increase the apparent toxicity of low levels of mercury.

TITLE

Mercury toxicity: Genetic susceptibility and synergistic effects

CITATION

Haley BE. Medical Veritas. 2005;2:535–542.

SUMMARY

This article discusses mercury intoxication and several normally appearing factors that increase the susceptibility to mercury toxicity. Boys with autism represent a subset of the population that is more susceptible to the toxic effects of mercury and thimerosal because they are not efficient excretors of these toxic materials. Research confirms that a lead-toxic person would be more susceptible to mercury toxicity than a healthy, non-toxic person. Researchers routinely observe that many heavy metals increase the apparent toxicity of low levels of mercury. In other words, the synergistic effects of other heavy metals, diet, antibiotics, etc. on mercury toxicity make it impossible to define a “safe level of mercury exposure.”

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Published: 2004
SYNOPSIS

Scientists identify vaccine mercury’s role in blocking crucial neurodevelopmental pathways.

TITLE

Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal

CITATION

M Waly, H Olteanu, R Banerjee, S-W Choi, JB Mason, BS Parker, S Sukumar, S Shim,
A Sharma, JM Benzecry, V-A Power-Charnitsky and RC Deth. Molecular Psychiatry , (2004) 9, 358–370.

SUMMARY

“The ethylmercury-containing preservative thimerosal inhibited both IGF-1- and dopamine-stimulated methylation with an IC50 of 1nM and eliminated MS activity. Our findings outline a novel growth factor signaling pathway that regulates MS activity and thereby modulates methylation reactions, including DNA methylation. The potent inhibition of this pathway by ethanol, lead, mercury, aluminum and thimerosal suggest that it may be an important target of neurodevelopmental toxins.”

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Published: 2000
SYNOPSIS

UCLA researchers find the DTP vaccine is causing asthma.

TITLE

Effects of Diphtheria-Tetanus-Pertussis or Tetanus Vaccination on Allergies and Allergy-Related Respiratory Symptoms Among Children and Adolescents in the United States

CITATION

Eric L. Hurwitz, DC, PhD, and Hal Morgenstern, PhD. Journal of Manipulative and Physiological Therapeutics, Volume 23, Number 2, February 2000.

SUMMARY

“Asthma and other allergic hypersensitivity reactions and related symptoms may be caused, in part, by the delayed effects of DTP or tetanus vaccination. Because the proportion of US children who have received at least 1 dose of DTP vaccine approaches 100%, the number of allergies and allergy-related conditions attributable to DTP or tetanus vaccination in the United States may be very high. For example, assuming that the estimated vaccination effect is unbiased, 50% of diagnosed asthma cases (2.93 million) in US children and adolescents would be prevented if the DTP or tetanus vaccination was not administered.”

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Published: 1953
SYNOPSIS

Aluminum caused tics and grand mal seizures in monkeys.

TITLE

Experimental Epilepsy in the Monkey Following Multiple Intracerebral Injections of Alumina Cream

CITATION

Joseph G. Chusid, Lenore M. Kopeloff, Ph.D. and Nicholas Kopeloff, Ph.D. The Bulletin, 1953.

SUMMARY

The multiple intracerebral injection of alumina cream (aluminum hydroxide cream) into a principal cerebral sensorimotor cortical area is effective in producing chronic epilepsy in monkeys. In all injected animals a variable degree of contralateral hemiparesis was obvious immediately after operation. In five of the six monkeys injected unilaterally, spontaneous contralateral focal motor seizures were evident three to four weeks after operation. Initially there occurred almost continuous twitch-like movements of varying amplitude and regularity, involving the musculature of the contralateral face and limbs. Excitement, agitation, movement or stress readily aggravated and accentuated this type of motor activity and sometimes led to Jacksonian spread with full-blown generalized convulsive seizure and exhaustion.

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