Science Library Category:

Autism

Published: 2013
SYNOPSIS

Canadian researchers: aluminum in vaccines can cause both autoimmunity and neurological damage.

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Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity

CITATION

Shaw C, Tomljenovic L. Immunologic Research. 2013;56:304–316.

SUMMARY

“In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome. Aluminum is added to vaccines to help the vaccine work more effectively, but unlike dietary aluminum which will usually clear rapidly from the body, aluminum used in vaccines and injected is designed to provide a long-lasting cellular exposure. Thus, the problem with vaccine-derived aluminum is really twofold: It drives the immune response even in the absence of a viral or bacterial threat and it can make its way into the central nervous system. It is not really a matter of much debate that aluminum in various forms can be neurotoxic.”

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Published: 2013
SYNOPSIS

Infants receiving mercury-containing vaccines had much higher rates of autism than infants receiving vaccines without mercury.

TITLE

A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States

CITATION

Geier DA, Hooker BS, Kern JK, King PG, Sykes LK, Geier MR. Translational Neurodegeneration. 2013;2:25.

SUMMARY

“The present study provides new epidemiological evidence supporting an association between increasing organic-Hg [mercury] exposure from Thimerosal-containing childhood vaccines and the subsequent risk of ASD [autism] diagnosis.”

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Published: 2013
SYNOPSIS

There is a connection between infant and prenatal thimerosal exposure and neurological disorders.

TITLE

Low-dose mercury exposure in early life: Relevance of thimerosal to fetuses, newborns and infants

CITATION

Dórea JG. Current Medicinal Chemistry. 2013;20:4060-4069.

SUMMARY

This review article highlights the scientifically affirmed connection between infant and prenatal thimerosal exposure and neurological disorders, including tic disorder, which has been shown to be much more prevalent in children with autism. The author also delineates the use of thimerosal in vaccines in developing countries at a greater exposure level than developed countries such as the U.S.

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Published: 2012
SYNOPSIS

Polish scientists propose new vaccine schedule, express concern at high rate of vaccine adverse events.

TITLE

Neurologic adverse events following vaccination

CITATION

Sienkiewicz D, Kulak W, Okurowska-Zawada B, Paszko-Patej G. Progress in Health Sciences. 2012;2.

SUMMARY

“[I]t is not reasonable to assume that manipulation of the immune system through an increasing number of vaccinations during critical periods of brain development will not result in adverse neurodevelopmental outcomes. European countries have different models of vaccination that have been modified in recent decades. In Scandinavian countries, which have the lowest infant mortality, vaccinations are voluntary and infants receive their first vaccination at 3 months of age. In the first year of life, they receive 9 recommended vaccinations, and at 18 months – MMR. The acellular pertussis vaccine (DTaP) is used, as well as IPV. BCG and Hepatitis B vaccines are administered to children from high risk groups. Similar vaccination schedules exist in other European countries, where the vaccination of neonates was abandoned and a ban on the use of thimerosal in vaccines was introduced. Note also that Scandinavian countries have the lowest rates of autism compared to other developed countries in which children are vaccinated much earlier and with greater number of vaccines.”

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Published: 2011
SYNOPSIS

Canadian researchers report vaccine aluminum and autism prevalence related.

TITLE

Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?

CITATION

Tomljenovic L, Shaw CA. Journal of Inorganic Biochemistry. 2011;105:1489-1499.

SUMMARY

“Dysfunctional immunity and impaired brain function are core deficits in ASD. Aluminum (Al), the most commonly used vaccine adjuvant, is a demonstrated neurotoxin and a strong immune stimulator. Hence, adjuvant Al has the potential to induce neuroimmune disorders. The application of the Hill’s criteria to these data indicates that the correlation between Al in vaccines and ASD may be causal. Because children represent a fraction of the population most at risk for complications following exposure to Al, a more rigorous evaluation of Al adjuvant safety seems warranted. By satisfying eight of the Hill’s criteria for establishing causality applicable to our study, we show that Al-adjuvanted vaccines may be a significant etiological factor in the rising prevalence of ASD in the Western world. We also show that children from countries with the highest ASD prevalence appear to have a much higher exposure to Al from vaccines, particularly at 2 months of age.”

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Published: 2010
SYNOPSIS

Scientists review literature and raise concerns about denial of environmental toxin link to autism.

TITLE

Sorting out the spinning of autism: heavy metals and the question of incidence

CITATION

DeSoto MC, Hitlan RT. ACTA Neurobiological Experimentals. 2010;70:165–176.

SUMMARY

“In this paper, we argue that increasingly over the past decade, positions that deny a link to environmental toxins and autism are based on relatively weak science and are disregarding the bulk of scientific literature. The question about toxic exposure and autism is open, with the weight of evidence favoring a connection that is not well understood. Although it is not possible to say with certainty, it seems likely that the connection would be mediated by genetic susceptibility and ability to detoxify. That is, some people have genotypes that confer higher susceptibility to toxic exposures. If so, then 50 years ago few people would have had enough toxic exposure to have the neurological changes that result in autism.”

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Published: 2010
SYNOPSIS

SUNY-Stony Brook scientists find boys receiving the hepatitis B vaccine series are three times more likely to have autism.

TITLE

Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997-2002

CITATION

Gallagher C, Goodman M. Journal of Toxicology and Environmental Health, Part A. 2010;73:1665–1677.

SUMMARY

“Boys vaccinated as neonates had threefold greater odds for autism diagnosis compared to boys never vaccinated or vaccinated after the first month of life. Findings suggest that U.S. male neonates vaccinated with the hepatitis B vaccine prior to 1999 (from vaccination record) had a threefold higher risk for parental report of autism diagnosis compared to boys not vaccinated as neonates during that same time period.”

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Published: 2010
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British and Swedish scientists raise concerns about limited understanding of vaccine aluminum’s impact on the human body, raise risk of autoimmune response.

TITLE

The immunobiology of aluminium adjuvants: how do they really work?

CITATION

Exley C, Siesjo P, Eriksson H. Trends in Immunology. 2010;31:103-109.

SUMMARY

“Boys vaccinated as neonates had threefold greater odds for autism diagnosis compared to boys never vaccinated or vaccinated after the first month of life. Findings suggest that U.S. male neonates vaccinated with the hepatitis B vac- cine prior to 1999 (from vaccination record) had a threefold higher risk for parental report of autism diagnosis compared to boys not vaccinated as neonates during that same time period.”

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Published: 2008
SYNOPSIS

A CDC-sponsored database showed much higher rates of neurodevelopmental disabilities from mercury-containing vaccines.

TITLE

Thimerosal exposure in infants and neurodevelopmental disorders: An assessment of computerized medical records in the Vaccine Safety Datalink

CITATION

Young HA, Geier DA, Geier MR. Journal of the Neurological Sciences. 2008;121:626-631.

SUMMARY

“Consistent significantly increased rate ratios were observed for autism, autism spectrum disorders, tics, attention deficit disorder, and emotional disturbances with Hg [mercury] exposure from TCVs [thimerosal-containing vaccines]. By contrast, none of the control outcomes had significantly increased rate ratios with Hg exposure from TCVs.”

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Published: 2005
SYNOPSIS

Many heavy metals increase the apparent toxicity of low levels of mercury.

TITLE

Mercury toxicity: Genetic susceptibility and synergistic effects

CITATION

Haley BE. Medical Veritas. 2005;2:535–542.

SUMMARY

This article discusses mercury intoxication and several normally appearing factors that increase the susceptibility to mercury toxicity. Boys with autism represent a subset of the population that is more susceptible to the toxic effects of mercury and thimerosal because they are not efficient excretors of these toxic materials. Research confirms that a lead-toxic person would be more susceptible to mercury toxicity than a healthy, non-toxic person. Researchers routinely observe that many heavy metals increase the apparent toxicity of low levels of mercury. In other words, the synergistic effects of other heavy metals, diet, antibiotics, etc. on mercury toxicity make it impossible to define a “safe level of mercury exposure.”

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Published: 2003
SYNOPSIS

An association between neurodevelopmental disorders and thimerosal-containing DTaP vaccines was found.

TITLE

Neurodevelopmental disorders after thimerosal-containing vaccines: a brief communication

CITATION

Geier MR, Geier DA. Experimental Biology and Medicine. 2003;228:660-664.

SUMMARY

An analysis of the Vaccine Adverse Events Reporting System (VAERS) database showed statistically significant increases in the incidence rate of autism (relative risk [RR] = 6.0), mental retardation (RR = 6.1), and speech disorders (RR = 2.2) after thimerosal-containing diphtheria, tetanus, and acellular pertussis (DTaP) vaccines in comparison with thimerosal-free DTaP vaccines.

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Published: 2002
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Utah state scientists find autoimmune reaction to MMR in children with autism, including autoimmunity to myelin basic protein, a brain building-block.

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Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism

CITATION

Singh VK, Lin SX, Newell E, Nelson C. Journal of Biomedical Science. 2002;9:359–364.

SUMMARY

“[A]s described herein, autistic children showed a serological correlation between MMR and brain autoimmunity, i.e., over 90% of MMR antibody-positive autistic sera also had autoantibodies to brain MBP. This is quite an intriguing observation in favor of a connection between atypical measles infection and autism; an atypical infection usually refers to infection that occurs in the absence of a rash. An atypical measles infection in the absence of a rash and unusual neurological symptoms was recently described to suggest the existence of a variant MV in children and adults. In light of these new findings, we suggest that a considerable proportion of autistic cases may result from an atypical measles infection that does not produce a rash but causes neurological symptoms in some children. The source of this virus could be a variant MV or it could be the MMR vaccine.”

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Published: 2000
SYNOPSIS

Infants receiving mercury-containing vaccines developed speech disorders, sleep disorders and autism, according to CDC scientists.

TITLE

Increased risk of developmental neurologic impairment after high exposure to thimerosal-containing vaccine in first month of life

CITATION

Verstraeten TM, Davies R, Gu D, DeStefano F. Proceedings of the Epidemic Intelligence Service Annual Conference, April 2000.

SUMMARY

“This analysis suggests that high exposure to ethylmercury from thimerosal-containing vaccines in the first month of life increases the risk of subsequent development of neurologic development impairment.”

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Published: 2000
SYNOPSIS

Japanese scientists find vaccine-strain of measles in the guts of children with autism.

TITLE

Detection and sequencing of measles virus from peripheral mononuclear cells from patients with inflammatory bowel disease and autism

CITATION

Kawashima H, Mori T, Kashiwagi Y, Takekuma K, Hoshika A, Wakefield A. Digestive Diseases and Sciences. 2000;45:723–729.

SUMMARY

“Additionally, a new syndrome has been reported in children with autism who exhibited developmental regression and gastrointestinal symptoms (autistic enterocolitis), in some cases soon after MMR vaccine. The sequences obtained from the patients with ulcerative colitis and children with autism were consistent with being vaccine strains. The results were concordant with the exposure history of the patients. Persistence of measles virus was confirmed in PBMC in some patients with chronic intestinal inflammation.”

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