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Redox Imbalance

Increased susceptibility to ethylmercury-induced mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines
Published: 2015
SYNOPSIS

Research confirms a link between environmental mercury exposure and an increased risk of autism and shows that some individuals are more susceptible than others.

CITATION

Rose S, Wynne R, Frye RE, Melnyk S, James SJ. Journal of Toxicology. 2015, Article ID 573701.

SUMMARY

The association of autism spectrum disorders with oxidative stress, redox imbalance, and mitochondrial dysfunction has become increasingly recognized. In this study, researchers compared mitochondrial respiration in lymphoblastoid cell lines (LCLs) from individuals with autism and unaffected controls exposed to ethylmercury, an environmental toxin known to deplete glutathione and induce oxidative stress and mitochondrial dysfunction. They also tested whether pretreating the autism LCLs with N-acetyl cysteine (NAC) to increase glutathione concentrations conferred protection from ethylmercury. The findings suggest that the link between environmental mercury exposure and an increased risk of developing autism may be mediated through mitochondrial dysfunction and support the notion that a subset of individuals with autism may be vulnerable to environmental influences with detrimental effects on development through mitochondrial dysfunction.

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