Multiple Sclerosis-MS
Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?
SYNOPSIS
A number of factors can predispose susceptible individuals to autoimmune reactions following vaccination.
CITATION
Vadalà M, Poddighe D, Laurino C, Palmieri B. European Association for Predictive Preventive & Personalized Medicine Journal. 2017;8(3):295-311.
SUMMARY
This review discusses possible underlying mechanisms of autoimmune reactions following vaccinations and cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are possible mechanisms by which vaccines can cause autoimmune reactions. The individuals who might be susceptible to develop these reactions could be those with previous post-vaccination phenomena, those with allergies, individuals who are prone to develop autoimmune diseases (such as those with a family history of autoimmunity or with known autoantibodies) and genetically predisposed individuals.
Vaccines and autoimmune diseases of the adult
SYNOPSIS
It is feasible that vaccinations may contribute to the mosaic of autoimmunity.
CITATION
Orbach H, Agmon-Levin N, Zandman-Goddard G. Discovery Medicine. 2014;10(2):101-107.
SUMMARY
Infectious agents contribute to the environmental factors involved in the development of autoimmune diseases possibly through molecular mimicry mechanisms. Hence, it is feasible that vaccinations may also contribute to the mosaic of autoimmunity. Evidence for the association of vaccinations and the development of these diseases is presented in this review.