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Science Library Abstract
Published: 2011
SYNOPSIS

Harvard researchers find vaccine mercury impacts neurodevelopment in rats.

TITLE

Maternal Thimerosal Exposure Results in Aberrant Cerebellar Oxidative Stress, Thyroid Hormone Metabolism, and Motor Behavior in Rat Pups; Sex- and Strain-Dependent Effects

CITATION

Z. L. Sulkowski & T. Chen & S. Midha & A. M. Zavacki & Elizabeth M. Sajdel-Sulkowska. Cerebellum, (2012) 11:575–586.

SUMMARY

“Our data indicate that maternal TM exposure results in a delayed auditory maturation and impaired motor learning in rat pups. Factors that may contribute to these abnormalities include increased cerebellar oxidative stress and decreased D2 activity resulting local intracerebellar T3 deficiency and altered TH-dependent gene expression. Indeed, provided here is the first evidence of altered TH-dependent gene expression following TM exposure. Our data thus demonstrate a negative neurodevelopmental impact of perinatal TM exposure, which appears to be both strain- and sex-dependent. Although, additional studies are needed, data derived from TM exposure in rats may provide clues relevant to understanding neurodevelopmental consequences of TM exposure in humans.”

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