Science Library Category:

Vaccine Safety

Published: 2018
SYNOPSIS

Aluminum adjuvants in vaccines can initiate and promote feline cancers.

TITLE

Feline vaccine-associated sarcomagenesis: is there an inflammation-independent role for aluminium?

Citation

AbdelMageed MA, Foltopoulou P, McNeil EA. Feline vaccine-associated sarcomagenesis: is there an inflammation-independent role for aluminium? Veterinary and Comparative Oncology. 2018;16(1):E130-E143.

 

Summary

This study, which examined whether aluminum adjuvants in vaccines can cause tumors in cats, found that the aluminum hydroxide adjuvant causes DNA damage and mutation. The study followed up on the observation that up to 10 of every 10,000 vaccinated cats develop an aggressive and invasive feline cancer at the site of vaccine administration within one to three years post-vaccination. The study confirmed that aluminum is highly persistent, continues to damage cells “for significant periods of time after initial exposure” and may “directly facilitate carcinogenesis” through the initiation and promotion of tumors.

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Published: 2018
SYNOPSIS

The contamination of vaccines with animal proteins that resemble human proteins can trigger autoimmunity.

TITLE

Cancer immunology, bioinformatics and chemokine evidence link vaccines contaminated with animal proteins to autoimmune disease: a detailed look at Crohn’s disease and Vitiligo

Citation

Arumugham V, Trushin MV. Cancer immunology, bioinformatics and chemokine evidence link vaccines contaminated with animal proteins to autoimmune disease: a detailed look at Crohn’s disease and Vitiligo. Journal of Pharmaceutical Sciences and Research. 2018;10(8):2106-2110.

Summary

Vaccines are contaminated with animal proteins that resemble human proteins, and this can result in autoimmunity. This study, which used bioinformatics to analyze animal proteins in vaccines and their similarity to human proteins, adds to growing evidence of vaccines inducing autoimmune diseases such as type 1 diabetes, Crohn’s disease, vitiligo, systemic lupus erythematosus and rheumatoid arthritis. The authors suggest that the live viruses and aluminum adjuvants in certain vaccines can stimulate the activation of particular T cells that, upon activation, may cause autoimmune disease. Because autoimmune reactions vary from person to person, “not everyone will develop overt disease”; thus, autoimmune illness may represent the tip of a broader “iceberg” of subclinical effects.

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Published: 2018
SYNOPSIS

Severe, long-term disability and even death can occur in a subset of individuals vulnerable to “HPV vaccination syndrome.”

TITLE

Autoimmunity, autonomic neuropathy, and the HPV vaccination: a vulnerable subpopulation

Citation

Schofield JR, Hendrickson JE. Autoimmunity, autonomic neuropathy, and the HPV vaccination: a vulnerable subpopulation. Clinical Pediatrics. 2018;57(5):603-606.

Summary

The authors describe the first biopsy-proven case of serious nerve damage developing within days of HPV vaccination, with an evident link between symptom onset and vaccination. The authors advocate for “increased [provider] awareness of the potential for neurological complications” resulting from HPV vaccination, particularly due to the “devastating clinical outcome of severe, long-term disability and even death of [a vulnerable subset] affected by the HPV vaccination syndrome.”

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Published: 2017
SYNOPSIS

Serious adverse events observed in pre-licensure trials of Gardasil-9 cast doubts on HPV vaccine safety, but the trial investigators described the adverse events as not vaccine-related.

TITLE

Vaccine-related serious adverse events might have been under-recognized in the pivotal HPV vaccine randomized trial

Citation

Martínez-Lavín M. Vaccine-related serious adverse events might have been under-recognized in the pivotal HPV vaccine randomized trial [Letter]. Clinical Rheumatology 2017;36(4):975.

 

Summary

The largest pre-licensure trial of the Gardasil-9 vaccine—which compared Gardasil-9 against Gardasil rather than against an inert placebo—showed that Gardasil-9 had significantly more serious adverse events than Gardasil (3.3% versus 2.6%, p=0.01). However, the trial investigators judged that 0% of the serious adverse events in both groups were vaccine-related. Gardasil-9 has “more than double [the] HPV virus-like particles and aluminum adjuvant” as Gardasil. The under-recognition of serious adverse events associated with Gardasil-9 “casts further doubt on HPV vaccine safety.”

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Published: 2015
SYNOPSIS

There is evidence of a significant relationship between increasing organic mercury exposure from Thimerosal-containing vaccines and the subsequent risk of PDD diagnosis in males and females.

TITLE

A Case-Control Study Evaluating the Relationship Between Thimerosal-Containing Haemophilus influenzae Type b Vaccine Administration and the Risk for a Pervasive Developmental Disorder Diagnosis in the United States

CITATION

David A. Geier & Janet K. Kern & Paul G. King & Lisa K. Sykes & Mark R. Geier; Biological Trace Element Research, (2015) 163:28–38.

SUMMARY

In this case-control study of pervasive development disorder (PDD) in U.S. children, cases were consistently exposed to higher levels of thimerosal via infant vaccines at both 6 months of age and 15 months of age, based specifically on Haemophilus influenzae type b vaccines. Differences between exposures in cases and controls were statistically significant at both ages evaluated.

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Published: 2014
SYNOPSIS

Background data (not reported in print) suggests a strong link between thimerosal exposure and autism.

TITLE

Methodological Issues and Evidence of Malfeasance in Research Purporting to Show Thimerosal in Vaccines Is Safe

CITATION

Brian Hooker, Janet Kern, David Geier, Boyd Haley, Lisa Sykes, Paul King, and Mark Geier; BioMed Research International, Volume 2014, Article ID 247218, 8 pages.

SUMMARY

This review article shows methodological flaws in six separate CDC studies claiming that thimerosal does not cause autism. In three specific instances (Madsen et al. 2003, Verstraeten et al. 2003 and Price et al. 2010) evidence of malfeasance on the part of CDC scientists is shown. Background data (not reported in print) from these three publications suggest a strong link between thimerosal exposure and autism.

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Published: 2014
SYNOPSIS

Vaccination can trigger adverse events in genetically susceptible individuals.

TITLE

The ontology of genetic susceptibility factors (OGSF) and its application in modeling genetic susceptibility to vaccine adverse events

Citation

Lin Y, He Y. The ontology of genetic susceptibility factors (OGSF) and its application in modeling genetic susceptibility to vaccine adverse events. Journal of Biomedical Semantics. 2014;5:19.

 

Summary

Vaccination can trigger adverse events in genetically susceptible individuals. The researchers describe their framework for measuring the robustness of the genetic association with specific vaccine adverse events.

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