Science Library Category:

Meningitis (A,C,W,Y) or (B)

Published: 2017
SYNOPSIS

Adolescents given meningococcal vaccines have experienced a wide variety of serious adverse events, including new autoimmune conditions and death.

TITLE

Post-licensure safety surveillance study of routine use of quadrivalent meningococcal diphtheria toxoid conjugate vaccine

CITATION

Hansen J, Zhang L, Klein NP, et al. Vaccine 2017;35(49 Pt B):6879-84.

 

SUMMARY

Adolescents receiving the Menactra® meningococcal vaccine (MenACWY-D) in 2005-2006 experienced a variety of adverse events in the six months following vaccination—including death—but the researchers (one of whom was affilated with the vaccine’s manufacturer, Sanofi Pasteur) concluded that only two diagnoses (diabetes and juvenile rheumatoid arthritis) were “possibly related to vaccination.” After comparing 31,000 Kaiser Permanente patients who received the MenACWY-D vaccine to 31,000 matched teens who had received a tetanus-diphtheria (Td) or hepatitis vaccine the previous year, the researchers assessed 1660 outcomes and determined that 1.3% were “significantly elevated” in the meningococcal group. There were two deaths in vaccinees with cancer (“with onset preceding vaccination”) following MenACWY-D vaccination as well as a third cardiac-related death; there was also one fetal death in a young woman who received Menactra® during pregnancy. Many of the adverse events, including difficulty breathing, occurred two or more months following vaccination.

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Published: 2017
SYNOPSIS

Yale scientists find strong association between vaccinations and anorexia, ocd, and anxiety disorder.

TITLE

Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case-Control Study

CITATION

Douglas L. Leslie, Robert A. Kobre, Brian J. Richmand. Frontiers in Psychiatry, January 2017.

SUMMARY

“Subjects with newly diagnosed anorexia nervosa were more likely than controls to have had any vaccination in the previous 3 months [hazard ratio (HR) 1.80, 95% confidence interval 1.21-2.68]. Influenza vaccinations during the prior 3, 6, and 12 months were also associated with incident diagnoses of AN, OCD, and an anxiety disorder. Several other associations were also significant with HRs greater than 1.40 (hepatitis A with OCD and AN; hepatitis B with AN; and meningitis with AN and chronic tic disorder). This pilot epidemiologic analysis implies that the onset of some neuropsychiatric disorders may be temporally related to prior vaccinations in a subset of individuals.”

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