Science Library Category:

Adjuvants (Aluminum, Squalene, etc.)

Published: 2017
SYNOPSIS

Aluminum adjuvant promotes brain inflammation and males appear to be more susceptible to Aluminum’s toxic effects.

TITLE

Subcutaneous injections of aluminum at vaccine adjuvant levels activate innate immune genes in mouse brain that are homologous with biomarkers of autism

CITATION

Dan Li, Lucija Tomljenovic, Yongling Li, Christopher A. Shaw. Journal of Inorganic Biochemistry, 177 (2017) 39–54 1953.

SUMMARY

Autism manifested in early childhood, during a window of early developmental vulnerability where the normal developmental trajectory is most susceptible to xenobiotic insults. Aluminum (Al) vaccine adjuvants are xenobiotics with immunostimulating and neurotoxic properties to which infants worldwide are routinely exposed. These researchers found appears that Aluminum triggered innate immune system activation and altered neurotransmitter activity in male mice, observations which are consistent with those in autism. Female mice were less susceptible to Aluminum as frontal cortex was the most affected area in males and cerebellum in females. Thus, Aluminum adjuvant promotes brain inflammation and males appear to be more susceptible to Aluminum ′s toxic effects. (In full transparency, this study has since been retracted by the Journal of Inorganic Biochemistry, but we felt it was an important topic so therefore have elected to keep it in our science library.)

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