Wheeze
Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan
SYNOPSIS
The prevalence of asthma, wheeze and eczema among children at 12 months of age might be related to the amount of inactivated vaccine exposure before 6 months of age.
CITATION
Yamamoto-Hanada et al. Environmental Health and Preventive Medicine (2020) 25:27
https://doi.org/10.1186/s12199-020-00864-7
SUMMARY
Adjuvants used in inactivated vaccines often upregulate type 2 immunity, which is dominant in allergic diseases. The authors hypothesised that cumulative adjuvant exposure in infancy may influence the development of allergies later in life by changing the balance of type 1/type 2 immunity and examined the relationship between immunisation with different vaccine types and later allergic disease development. They found that physician-diagnosed asthma was associated with receiving three or four to five different inactivated vaccines, compared with children who received only one inactivated vaccine. Similar results were found for two questionnaire-based symptoms, i.e. wheeze (three vaccines vs. a single vaccine) and
eczema (four or five vaccines vs. a single vaccine).