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Vaccine Injury

Do gut microbiota mediate adverse vaccine reaction?
Published: 2021
SYNOPSIS

Gut microbiota have a significant effect on host response to vaccination where a reduced or absent population of commensal flora coupled with an overgrowth of pathogenic strains may become a microbial predisposition to adverse vaccine reaction.

CITATION

Yuan L, Tsai PCC, Bell K. Do gut microbiota mediate adverse vaccine reaction? Ann Clin Trials Vaccines Res. 2018;2(2):11-12.

SUMMARY

The Yuan Lab has developed Gn pig models representing HGM as healthy (HHGM) and unhealthy (UHGM). They found that vaccinated UHMG pigs had higher viral shedding titres and more severe clinical signs compared to HHGM pigs after virulent HRV challenge. In another study, they found that Lactobacillus partially prevented intestinal injury caused by HRV, ameliorating rotavirus diarrhea. Such studies clearly demonstrate the protective nature of commensal flora and that differences in immune responses and clinical disease are due to the influence of microbial differences.

There is potential for future research using Gn pigs to test childhood vaccines such as Hepatitis B vaccine, currently administered within 12 hours of birth per CDC schedule.

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Multiple Vaccinations and the Enigma of Vaccine Injury
Published: 2020
SYNOPSIS

The increasing rates of allergy, ear infections, and neurodevelopmental disorders (NDDs) in countries with high rates of vaccination could be related to mass vaccination and to its impact on liver function and vitamin A metabolism.

CITATION

Mawson, A.R.; Croft, A.M. Multiple Vaccinations and the Enigma of Vaccine Injury. Vaccines 2020, 8, 676.

SUMMARY

Mawson and Croft have written a comprehensive review article in the journal Vaccines and have investigated the role of multiple vaccinations in long term health effects include neurodevelopmental disorders, allergies, infections and neuropsychiatric disorders.  Past research on vaccine adverse events highlighted in the paper includes multiple childhood vaccines as well as multiple vaccines given to military personnel during the Gulf war.   Mawson and Croft hypothesize that multiple vaccines trigger the retinoid cascade which initiates apoptotic hepatitis that releases stored vitamin A compounds into circulation in toxic concentrations.  Further, the authors link vitamin A toxicity to multiple adverse events following vaccination.

This review article is a very important contribution to the science around vaccine injury, especially injuries following multiple vaccinations which given the bloated CDC infant vaccination schedule is the rule and not the exception.  Mawson has previously completed his own study of vaccinated versus unvaccinated children where he found relationships between vaccination status and multiple sequelae including allergic rhinitis, eczema, otitis media, pneumonia and neurodevelopmental disorders (Mawson et al. 2017, J Transl Sci).

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Bilateral deafness two days following influenza vaccination: a case report
Published: 2019
SYNOPSIS

This case report describes bilateral deafness following influenza vaccination.

Citation

Kolarov C, Lobermann M, Fritsche C, Hemmer C, Mlynski R, Reisinger EC. Bilateral deafness two days following influenza vaccination: a case report. Human Vaccines & Immunotherapeutics. 2019;15(1):107-108.

 

Summary

This case report describes bilateral deafness following influenza vaccination in a 79-year-old woman with previously normal hearing.

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Bilateral deafness two days following influenza vaccination: a case report
Published: 2019
SYNOPSIS

This case report describes bilateral deafness following influenza vaccination.

CITATION

Kolarov C, Lobermann M, Fritsche C, Hemmer C, Mlynski R, Reisinger EC.  Human Vaccines & Immunotherapeutics. 2019;15(1):107-108.

SUMMARY

This case report describes bilateral deafness following influenza vaccination in a 79-year-old woman with previously normal hearing.

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The ontology of genetic susceptibility factors (OGSF) and its application in modeling genetic susceptibility to vaccine adverse events
Published: 2014
SYNOPSIS

Vaccination can trigger adverse events in genetically susceptible individuals.

Citation

Lin Y, He Y. The ontology of genetic susceptibility factors (OGSF) and its application in modeling genetic susceptibility to vaccine adverse events. Journal of Biomedical Semantics. 2014;5:19.

 

Summary

Vaccination can trigger adverse events in genetically susceptible individuals. The researchers describe their framework for measuring the robustness of the genetic association with specific vaccine adverse events.

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