SYNOPSIS
Gut microbiota have a significant effect on host response to vaccination where a reduced or absent population of commensal flora coupled with an overgrowth of pathogenic strains may become a microbial predisposition to adverse vaccine reaction.
TITLE
Do gut microbiota mediate adverse vaccine reaction?
CITATION
Yuan L, Tsai PCC, Bell K. Do gut microbiota mediate adverse vaccine reaction? Ann Clin Trials Vaccines Res. 2018;2(2):11-12.
SUMMARY
The Yuan Lab has developed Gn pig models representing HGM as healthy (HHGM) and unhealthy (UHGM). They found that vaccinated UHMG pigs had higher viral shedding titres and more severe clinical signs compared to HHGM pigs after virulent HRV challenge. In another study, they found that Lactobacillus partially prevented intestinal injury caused by HRV, ameliorating rotavirus diarrhea. Such studies clearly demonstrate the protective nature of commensal flora and that differences in immune responses and clinical disease are due to the influence of microbial differences.
There is potential for future research using Gn pigs to test childhood vaccines such as Hepatitis B vaccine, currently administered within 12 hours of birth per CDC schedule.