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Phosphoinositide 3-Kinase - PI3-Kinase

Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal
Published: 2004
SYNOPSIS

Scientists identify vaccine mercury’s role in blocking crucial neurodevelopmental pathways.

CITATION

M Waly, H Olteanu, R Banerjee, S-W Choi, JB Mason, BS Parker, S Sukumar, S Shim,
A Sharma, JM Benzecry, V-A Power-Charnitsky and RC Deth. Molecular Psychiatry , (2004) 9, 358–370.

SUMMARY

“The ethylmercury-containing preservative thimerosal inhibited both IGF-1- and dopamine-stimulated methylation with an IC50 of 1nM and eliminated MS activity. Our findings outline a novel growth factor signaling pathway that regulates MS activity and thereby modulates methylation reactions, including DNA methylation. The potent inhibition of this pathway by ethanol, lead, mercury, aluminum and thimerosal suggest that it may be an important target of neurodevelopmental toxins.”

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