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Pesticide

Current knowledge on endocrine disrupting chemicals (EDCs) from animal biology to humans, from pregnancy to adulthood: Highlights from a national Italian meeting
Published: 2018
SYNOPSIS

The preponderance of the evidence indicates that mercury exposure is causal and/or contributory to ASD.

CITATION

Street ME, et al. International Journal of Molecular Sciences. 2018;19:1647.

SUMMARY

This manuscript reviews the reports of a multidisciplinary national meeting on the effects of endocrine-disrupting chemicals (EDCs). Section 3 specifically discusses EDCs and neurodevelopmental diseases in humans, with a focus on autism. Recent studies point to an equal contribution of environmental factors (particularly environmental toxicants) and genetic susceptibility, but only a few industrial chemicals (e.g., lead [Pb], methylmercury, polychlorinated biphenyls [PCBs], and toluene) are recognized causes of neurodevelopmental disorders and subclinical brain dysfunction. Recent discoveries indicate that heavy metals such as cadmium (Cd), arsenic (As), mercury (Hg), nickel (Ni), and lead (Pb) may exhibit endocrine-disrupting activity in animal models, probably by interfering with zinc-fingers of nuclear estrogen receptors. The authors review research on mercury, PCBs, polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers, phthalates, BPAs and pesticides.

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Association of maternal insecticide levels with autism in offspring from a national birth cohort
Published: 2018
SYNOPSIS

The offspring of mothers exposed to DDT and its metabolites during pregnancy are at increased risk for autism.

Citation

Brown AS, Cheslack-Postava K, Rantakokko P, et al. American Journal of Psychiatry. 2018;175:1094-1101.

 

Summary

The study provides the first evidence based on biomarkers of an increased autism risk in the offspring of mothers exposed to certain insecticides during pregnancy. In this large national birth cohort study of Finnish children, the odds of autism plus intellectual disability were increased by greater than twofold in mothers measuring with the highest levels of a DDT metabolite.

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Synergistic effects of heavy metals and pesticides in living systems
Published: 2017
SYNOPSIS

Combined exposure to heavy metals and pesticides can lead to more severe effects on human health compared to their individual effects.

Citation

Singh N, Gupta VK, Kumar A, Sharma B. Synergistic effects of heavy metals and pesticides in living systems. Frontiers in Chemistry. 2017;5:70.

 

Summary

Combined exposure to heavy metals and pesticides can lead to more severe effects on human health compared to their individual effects. This review reports that various combinations (pesticides combined with pesticides, pesticides combined with heavy metals, and heavy metals combined with heavy metals) all act synergistically and exhibit more toxicity than a single toxin alone. More work is needed to study the biotransformation of heavy metals and pesticides in combination and the mechanisms by which they affect toxicity.

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