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Neuroinflammation

Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil
Published: 2016
SYNOPSIS

Israeli, Canadian and Colombian scientists show that the Gardasil vaccine triggers brain inflammation and autoimmunity in mice.

CITATION

Inbar R, Weiss R, Tomljenovic L, Arango M-T, Deri Y, Shaw CA, Chapman J, Blank M, Shoenfeld Y. Immunologic Research. 2017;65(1):136-149.

SUMMARY

“Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine trials utilize aluminum (Al) adjuvants as placebos despite much evidence showing that Al in vaccine-relevant exposures can be toxic to humans and animals…. It appears that Gardasil via its Al adjuvant and HPV antigens has the ability to trigger neuroinflammation and autoimmune reactions, further leading to behavioral changes…. In light of these findings, this study highlights the necessity of proceeding with caution with respect to further mass-immunization practices with a vaccine of yet unproven long-term clinical benefit in cervical cancer prevention.”

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The levels of blood mercury and inflammatory-related neuropeptides in the serum are correlated in children with autism spectrum disorder
Published: 2016
SYNOPSIS

Mercury exposure is implicated in neuroinflammatory disorders including autism.

CITATION

Mostafa GA, Bjørklund G, Urbina MA, Al-Ayadhi LY. Metabolic Brain Disease. 2016;31:593–599.

SUMMARY

Blood mercury levels and tachykinins (neuropeptides that cause inflammation) were correlated in children with ASD and statistically significantly higher than neurotypical control children. It has been shown that mercury exposure can elicit tachykinin formation, which has been implicated in neuroinflammatory disorders including autism.

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