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Mortality

Diabetes and Covid-19 among hospitalized patients in Saudi Arabia: a single-centre retrospective study.
Published: 2021
SYNOPSIS

Hospitalized COVID-19 patients with diabetes had a 85.7% lower death rate when given Vit D.

CITATION

Alguwaihes AM, Al-Sofiani ME, Megdad M, Albader SS, Alsari MH, Alelayan A, Alzahrani SH, Sabico S, Al-Daghri NM, Jammah AA. Diabetes and Covid-19 among hospitalized patients in Saudi Arabia: a single-centre retrospective study. Cardiovasc Diabetol. 2020 Dec 5;19(1):205. doi: 10.1186/s12933-020-01184-4. PMID: 33278893; PMCID: PMC7718833. Summary

SUMMARY

A total of 439 patients were included (median age 55 years; 68.3% men). The most prevalent comorbidities were vitamin D deficiency. While diabetes mellitus (DM) patients have a higher mortality rate than their non-DM counterparts, hospitalized patients showed 85.7%  lower mortality with vitamin D.

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Nutrients, High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study.
Published: 2021
SYNOPSIS

An 80% decrease in death among hospitalized (late treatment) patients in the UK given Vitamin D.

CITATION

Ling SF, Broad E, Murphy R, Pappachan JM, Pardesi-Newton S, Kong MF, Jude EB. High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study. Nutrients. 2020 Dec 11;12(12):3799. doi: 10.3390/nu12123799. PMID: 33322317; PMCID: PMC7763301.

SUMMARY

This is a late treatment retrospective study showing 80% lower mortality with cholecalciferol booster therapy of 986 hospitalized patients in the UK finding that cholecalciferol booster therapy, regardless of baseline serum levels, was associated with a reduced risk of mortality in acute COVID-19 inpatients. An 80% decrease in mortality in the primary cohort (444 patients).

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Annual Summary of Vital Statistics: Trends in the Health of Americans During the 20th Century
Published: 2000
SYNOPSIS

CDC scientists admit that 90% of infectious disease mortality decrease in the United States happened before vaccines were available.

CITATION

Bernard Guyer, MD, Mary Anne Freeman, MA, Donna M. Strobino, PhD, Edward J. Sondik, PhD. Pediatrics, Dec 2000, Vol. 106, No. 6.

SUMMARY

“Thus vaccination does not account for the impressive declines in mortality seen in the first half of the century…nearly 90% of the decline in infectious disease mortality among US children occurred before 1940, when few antibiotics or vaccines were available.”

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Trends in Infectious Disease Mortality in the United States During the 20th Century
Published: 1999
SYNOPSIS

Infectious disease rates declined precipitously in the united states in the 20th century before the implementation of a national vaccine program.

CITATION

Gregory L. Armstrong, MD, Laura A. Conn, MPH, Robert W. Pinner, MD. Journal of the American Medical Association, 1999, 281: 61-66.

SUMMARY

“During the first 8 decades of the 20th century, the infectious disease mortality rate in the United States declined substantially…Improvements in living conditions, sanitation, and medical care probably accounted for this trend.”

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