Science Library Category:
Methionine Synthase - MS
Alternatively spliced methionine synthase in SH-SY5Y neuroblastoma cells: Cobalamin and GSH dependence and inhibitory effects of neurotoxic metals and thimerosal
Published: 2016
SYNOPSIS
Thimerosal reduces people’s ability to make all-important vitamin B12 compounds that help the body detoxify and control inflammation—and B12 deficiencies and severely impaired detoxification are hallmarks of autism.
CITATION
Waly M, Power-Charnitsky V-A, Hodgson N, … Deth R. Oxidative Medicine and Cellular Longevity. 2016, Article ID 6143753.
SUMMARY
Thimerosal inhibited cellular production of cobalamin necessary for detoxification and amelioration of oxidative stress. This caused lower methionine synthase activity and an impaired methylation capacity. Autistic subjects in general show cobalamin deficiencies and severely impaired methylation.