Mechanical Ventilation
High dose vitamin D improves total serum antioxidant capacity and ICU outcome in critically ill patients – A randomized, double-blind clinical trial.
SYNOPSIS
Administration of vitamin D may increase TAC levels and decrease the length of stay and duration of mechanical ventilation in ICU patients.
CITATION
Mohammad Sistanizad, Mehran Kouchek, Mohammad Miri, Sara Salarian, Seyedpouzhia Shojaei, Fatemeh Moeini Vasegh, Hossein Seifi Kafshgari, Roja Qobadighadikolaei. High dose vitamin D improves total serum antioxidant capacity and ICU outcome in critically ill patients – A randomized, double-blind clinical trial. European Journal of Integrative Medicine, Volume 42, 2021,101271, ISSN 1876-3820, https://doi.org/10.1016/j.eujim.2020.101271.
SUMMARY
The results show that injection of vitamin D leads to a significant increase in the mean changes of vitamin D level on the seventh day of the study and Total Antioxidant Capacity (TAC) levels. ICU length of stay was lessened. Twelve patients in the placebo group and 5 in the vitamin D group died within the 28 day study period. The duration of mechanical ventilation was lessened in vitamin D and placebo arms. Authors do not indicate why the patients were hospitalized or if any of the patients were COVID-19 patients.