Macrophage
Macrophagic myofasciitis lesions assess long-term persistence of vaccine derived aluminum hydroxide in muscle
SYNOPSIS
French scientists tie aluminum adjuvant in vaccine to macrophagic myofasciitis.
CITATION
R.K. Gherardi, M. Coquet, P. Cherin, L. Belec, P. Moretto, P.A. Dreyfus. Brain, 2001, 124, 1821-1831.
SUMMARY
“Macrophagic myofasciitis (MMF) is an emerging condition of unknown cause, detected in patients with diffuse arthromyalgias and fatigue, and characterized by muscle infiltration by granular periodic acid-Schiff’s reagent-positive macrophages and lymphocytes. Intracytoplasmic inclusions have been observed in macrophages of some patients. To assess their significance, electron microscopy was performed in 40 consecutive cases and chemical analysis was done by microanalysis and atomic absorption spectrometry. Inclusions were constantly detected and corresponded to aluminium hydroxide, an immunostimulatory compound frequently used as a vaccine adjuvant.”