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France

Aluminum and silica in drinking water and the risk of Alzheimer’s disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort
Published: 2008
SYNOPSIS

Higher aluminum intake from drinking water is associated with an increased risk of cognitive decline, dementia and Alzheimer’s disease.

CITATION

Rondeau V, Jacqmin-Gadda H, Commenges D, Helmer C, Dartigues JF. Aluminum and silica in drinking water and the risk of Alzheimer’s disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort. American Journal of Epidemiology. 2009;169(4):489-496.

SUMMARY

A long-term study in Southern France found that a higher intake of aluminum from drinking water was linked to an increased risk of cognitive decline, dementia and Alzheimer’s disease. Conversely, an increase in silica intake (10 mg/day) reduced the risk of dementia. A unique feature of the study, which followed elderly individuals for 15 years, was its measurement of individual daily intake of drinking water (both tap and bottled water), in addition to assessing the geographical concentrations of aluminum and silica.

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