Mercury in the body produces a selenium deficiency state that increases toxicity.
Spiller HA. Rethinking mercury: the role of selenium in the pathophysiology of mercury toxicity. Clinical Toxicology. 2018;56(5):313-326.
This study makes the case that mercury’s multifaceted interactions with selenium are a central feature of mercury toxicity. The authors argue that “the previously suggested ‘protective effect’ of selenium against mercury toxicity may in fact be backwards”—because of mercury’s affinity for selenium, mercury can actually produce a selenium deficiency state that promotes oxidative stress and inhibits the body’s regenerative mechanisms. Depending on the form of mercury and other factors, selenium supplementation may have some benefits for restoring adequate selenium status and mitigating the toxicity of mercury, but it does not appear to promote increased elimination of mercury.
Aluminum and silica in drinking water and the risk of Alzheimer’s disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort
Higher aluminum intake from drinking water is associated with an increased risk of cognitive decline, dementia and Alzheimer’s disease.
Rondeau V, Jacqmin-Gadda H, Commenges D, Helmer C, Dartigues JF. Aluminum and silica in drinking water and the risk of Alzheimer’s disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort. American Journal of Epidemiology. 2009;169(4):489-496.
A long-term study in Southern France found that a higher intake of aluminum from drinking water was linked to an increased risk of cognitive decline, dementia and Alzheimer’s disease. Conversely, an increase in silica intake (10 mg/day) reduced the risk of dementia. A unique feature of the study, which followed elderly individuals for 15 years, was its measurement of individual daily intake of drinking water (both tap and bottled water), in addition to assessing the geographical concentrations of aluminum and silica.