Disease
Multiple Vaccinations and the Enigma of Vaccine Injury
SYNOPSIS
The increasing rates of allergy, ear infections, and neurodevelopmental disorders (NDDs) in countries with high rates of vaccination could be related to mass vaccination and to its impact on liver function and vitamin A metabolism.
CITATION
Mawson, A.R.; Croft, A.M. Multiple Vaccinations and the Enigma of Vaccine Injury. Vaccines 2020, 8, 676.
SUMMARY
Mawson and Croft have written a comprehensive review article in the journal Vaccines and have investigated the role of multiple vaccinations in long term health effects include neurodevelopmental disorders, allergies, infections and neuropsychiatric disorders. Past research on vaccine adverse events highlighted in the paper includes multiple childhood vaccines as well as multiple vaccines given to military personnel during the Gulf war. Mawson and Croft hypothesize that multiple vaccines trigger the retinoid cascade which initiates apoptotic hepatitis that releases stored vitamin A compounds into circulation in toxic concentrations. Further, the authors link vitamin A toxicity to multiple adverse events following vaccination.
This review article is a very important contribution to the science around vaccine injury, especially injuries following multiple vaccinations which given the bloated CDC infant vaccination schedule is the rule and not the exception. Mawson has previously completed his own study of vaccinated versus unvaccinated children where he found relationships between vaccination status and multiple sequelae including allergic rhinitis, eczema, otitis media, pneumonia and neurodevelopmental disorders (Mawson et al. 2017, J Transl Sci).
Persistent circulation of vaccine serotypes and serotype replacement after five years of UK infant immunisation with PCV13.
SYNOPSIS
PCV13 has reduced serotype 19A carriage among vaccinated children however, disease is not fully controlled. We also found, no impact of PCV13 on serotype 3 carriage or disease, and emergence of non-PCV13 serotype disease.
CITATION
Kandasamy, R., Voysey, M., Collins, S., et al. The Journal of Infectious Diseases, jiz178, 20 April 2019.
SUMMARY
Following programmatic introduction of the 13-valent pneumococcal conjugate vaccine (PCV13), there is residual carriage and disease due to PCV13 covered serotypes.
988 PCV13-immunised children aged 13-48 months were enrolled between February 2014 and August 2015 (late-PCV13), and had nasopharyngeal pneumococcal carriage compared with 567 PCV7-immunised children enrolled into a study between November 2010 and September 2011 (early-PCV13). Nasopharyngeal pneumococci were molecular-serotyped by microarray. Invasive pneumococcal disease (IPD) cases were identified through enhanced national surveillance. Blood collected from the late-PCV13 cohort was assessed for levels of serotype-specific serum IgG by multiplex immunoassay.
Compared with PCV7-immunised children, carriage among PCV13-immunised children was significantly lower for serotypes 19A (OR=0.08, 95% CI 0.02-0.25), 6C (OR=0.11, 95% CI 0.03-0.32) and 7F (8 vs 0 cases).
IPD incidence in children <5 years was significantly lower for serotypes 1 (IRR=0.03, 95% CI 0-0.19) and 7F (IRR=0.13, 95% CI 0.05-0.36) but not 19A (IRR=0.6, 95% CI 0.3-1.12) or serotype 3 (IRR=2.3, 95% CI 0.86-6.15) in the late-PCV13 period than in the early-PCV13 period. The most significant rises in IPD incidence were for serotypes 8, 12F, and 24F.
Children from the late-PCV13 period, who had serum analysed, and were not carrying a PCV13 serotype, had high levels of antibody presumed to be due to natural exposure, to serotypes 3 (24/204, 11.76%) and 19A (14/204, 6.86%).
PCV13 has reduced serotype 19A carriage among vaccinated children however, disease is not fully controlled. We also found, no impact of PCV13 on serotype 3 carriage or disease, and emergence of non-PCV13 serotype disease.
New Quality-Control Investigations on Vaccines: Micro- and Nanocontamination
SYNOPSIS
Italian scientists find unexpected contaminants in all pediatric vaccines, including lead, stainless steel, tungsten, iron, and chromium
CITATION
Dr. Antonietta M. Gatti, Stefano Montanari. International Journal of Vaccines and Vaccination, January 2017.
SUMMARY
Scientists found contaminants in all vaccines that are not listed on the label of the vaccines. “The analyses carried out show that in all samples checked vaccines contain non biocompatible and bio-persistent foreign bodies which are not declared by the Producers, against which the body reacts in any case. This new investigation represents a new quality control that can be adopted to assess the safety of a vaccine. Our hypothesis is that this contamination is unintentional, since it is probably due to polluted components or procedures of industrial processes (e.g. filtrations) used to produce vaccines, not investigated and not detected by the Producers. If our hypothesis is actually the case, a close inspection of the working places and the full knowledge of the whole procedure of vaccine preparation would probably allow to eliminate the problem.”