Diabetes
Type 1 diabetes mellitus following COVID-19 RNA-based vaccine
SYNOPSIS
Ten days after receiving a COVID-19 vaccination, a 36-year-old female patient visited the hospital with diabetic ketoacidosis and was diagnosed with type 1 diabetes.
K. Sakurai, D. Narita, N. Saito, T. Ueno, R. Sato, S. Niitsuma, K. Takahashi, Z. Arihara
The epidemic of coronavirus disease-2019 (COVID-19) is the major public health issue in the world. COVID-19 vaccines are one of the most effective strategies against COVID-19. Here we report a 36-year-old female patient who had thirst, polydipsia, polyuria, palpitations, loss of appetite, and fatigue 3 days after the first dose of COVID-19 RNA-based vaccines without a prior history of diabetes. Ten days after vaccination, she visited our hospital with diabetic ketoacidosis and was diagnosed with type 1 diabetes. Hyperglycemia (501 mg/dL), anion gap metabolic acidosis and ketonuria were observed. The glycated hemoglobin level was 7.0%. Islet-related autoantibodies were all negative. The glucagon tolerance test revealed attenuated secretion of insulin. Human leukocyte antigen was haplotype DRB1*0405-DQB1*0401, which was associated with type 1 diabetes in Japan. The present case suggests that COVID-19 RNA-based vaccines might trigger the onset of type 1 diabetes, even in subjects without prior histories of diabetes.
Diabetes and Covid-19 among hospitalized patients in Saudi Arabia: a single-centre retrospective study.
SYNOPSIS
Hospitalized COVID-19 patients with diabetes had a 85.7% lower death rate when given Vit D.
CITATION
Alguwaihes AM, Al-Sofiani ME, Megdad M, Albader SS, Alsari MH, Alelayan A, Alzahrani SH, Sabico S, Al-Daghri NM, Jammah AA. Diabetes and Covid-19 among hospitalized patients in Saudi Arabia: a single-centre retrospective study. Cardiovasc Diabetol. 2020 Dec 5;19(1):205. doi: 10.1186/s12933-020-01184-4. PMID: 33278893; PMCID: PMC7718833. Summary
SUMMARY
A total of 439 patients were included (median age 55 years; 68.3% men). The most prevalent comorbidities were vitamin D deficiency. While diabetes mellitus (DM) patients have a higher mortality rate than their non-DM counterparts, hospitalized patients showed 85.7% lower mortality with vitamin D.
In utero exposure to mercury and childhood overweight or obesity: counteracting effect of maternal folate status
SYNOPSIS
In this US urban, multi-ethnic population, elevated in utero Hg exposure was associated with a higher risk of over weight / obesity in childhood, and such risk was enhanced by maternal over weight / obesity and/or diabetes and reduced by adequate maternal folate.
CITATION
SUMMARY
Low-dose mercury (Hg) exposure has been associated with cardiovascular diseases, diabetes, and obesity in adults, but it is unknown the metabolic consequence of in utero Mercury exposure. This study aimed to investigate the association between in utero Mercury exposure and child overweight or obesity (OWO) and to explore if adequate maternal folate can mitigate Mercury toxicity.
Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?
SYNOPSIS
A number of factors can predispose susceptible individuals to autoimmune reactions following vaccination.
CITATION
Vadalà M, Poddighe D, Laurino C, Palmieri B. European Association for Predictive Preventive & Personalized Medicine Journal. 2017;8(3):295-311.
SUMMARY
This review discusses possible underlying mechanisms of autoimmune reactions following vaccinations and cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are possible mechanisms by which vaccines can cause autoimmune reactions. The individuals who might be susceptible to develop these reactions could be those with previous post-vaccination phenomena, those with allergies, individuals who are prone to develop autoimmune diseases (such as those with a family history of autoimmunity or with known autoantibodies) and genetically predisposed individuals.