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Dengue Fever

Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy
Published: 2018
SYNOPSIS

Dengue vaccine increases the risk of severe dengue in unexposed children.

CITATION

S. Sridhar, A. Luedtke, E. Langevin, M. Zhu, et al. The New England Journal of Medicine, (2018), DOI: 10.1056/NEJMoa1800820.

SUMMARY

In efficacy trials of a tetravalent dengue vaccine, study authors found: “…in the absence of previous dengue exposure, the (Sanofi) vaccine partially mimics primary infection and increases the risk of severe dengue.” (800,000 kids were already vaccinated before they pulled the vaccine.)

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