Science Library Category:

Dengue Fever

Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy
Published: 2018

Dengue vaccine increases the risk of severe dengue in unexposed children.


S. Sridhar, A. Luedtke, E. Langevin, M. Zhu, et al. The New England Journal of Medicine, (2018), DOI: 10.1056/NEJMoa1800820.


In efficacy trials of a tetravalent dengue vaccine, study authors found: “…in the absence of previous dengue exposure, the (Sanofi) vaccine partially mimics primary infection and increases the risk of severe dengue.” (800,000 kids were already vaccinated before they pulled the vaccine.)

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