Science Library Abstract
Published: 2018
SYNOPSIS
Dengue vaccine increases the risk of severe dengue in unexposed children.
TITLE
Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy
CITATION
S. Sridhar, A. Luedtke, E. Langevin, M. Zhu, et al. The New England Journal of Medicine, (2018), DOI: 10.1056/NEJMoa1800820.
SUMMARY
In efficacy trials of a tetravalent dengue vaccine, study authors found: “…in the absence of previous dengue exposure, the (Sanofi) vaccine partially mimics primary infection and increases the risk of severe dengue.” (800,000 kids were already vaccinated before they pulled the vaccine.)