Autoimmune/Inflammatory Syndrome Induced by Adjuvants – ASIA
Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil
SYNOPSIS
Israeli, Canadian and Colombian scientists show that the Gardasil vaccine triggers brain inflammation and autoimmunity in mice.
CITATION
Inbar R, Weiss R, Tomljenovic L, Arango M-T, Deri Y, Shaw CA, Chapman J, Blank M, Shoenfeld Y. Immunologic Research. 2017;65(1):136-149.
SUMMARY
“Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine trials utilize aluminum (Al) adjuvants as placebos despite much evidence showing that Al in vaccine-relevant exposures can be toxic to humans and animals…. It appears that Gardasil via its Al adjuvant and HPV antigens has the ability to trigger neuroinflammation and autoimmune reactions, further leading to behavioral changes…. In light of these findings, this study highlights the necessity of proceeding with caution with respect to further mass-immunization practices with a vaccine of yet unproven long-term clinical benefit in cervical cancer prevention.”
Autoimmune/inflammatory syndrome induced by adjuvants and Sjogren’s syndrome
SYNOPSIS
Israeli and Italian scientists warn that vaccine adjuvants (aluminum) are causing a wide-range of autoimmune conditions, including Sjogren’s Syndrome.
CITATION
Colafrancesco S, Perricone C, Shoenfeld Y. The Israel Medical Association Journal. 2016;18(3-4):150-153.
SUMMARY
Considerable evidence raises the possibility of vaccine-triggered autoimmunity. For example, case reports suggest that both vaccines and silicone may trigger the development of Sjogren’s syndrome (a chronic systemic autoimmune inflammatory condition involving the exocrine glands). Aluminum, one of the principal adjuvants used in vaccine formulation, may be responsible for the development of autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Aluminum salts seem to induce the activation of dendritic cells and complement components and increase the level of chemokine secretion at the injection site. Evidence also suggests that several vaccines, including BCG (tuberculosis), hepatitis A and/or B and human papillomavirus (HPV), should be avoided or considered only in selected individuals.
On vaccine’s adjuvants and autoimmunity: Current evidence and future perspectives
SYNOPSIS
The specific mechanism of action of each vaccine adjuvant may have different effects on the course of autoimmune conditions resulting from vaccination.
CITATION
Pellegrino P, Clementi E, Radice S. Autoimmunity Reviews. 2015;14(10):880-888.
SUMMARY
Adjuvants in vaccines have been implicated in “Autoimmune/inflammatory Syndrome Induced by Adjuvants” (ASIA), an umbrella of clinical conditions that includes post-vaccination adverse reactions. Aluminum-based compounds, in particular, are associated with the development of vaccine adjuvant-induced autoimmune diseases, but vaccines with other adjuvants may also cause specific autoimmune adverse reactions via different pathogenic mechanisms. The specific mechanism of action of each single adjuvant may have different effects on the course of different diseases.
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects
SYNOPSIS
Israeli and Italian researchers demonstrate that exposure to aluminum in vaccines can lead to autoimmune and brain dysfunction.
CITATION
Perricone C, Colafrancesco S, Mazor RD, Soriano A, Agmon-Levin N, Shoenfeld Y. Journal of Autoimmunity. 2013;47:1-16.
SUMMARY
Environmental factors play a critical role in the induction of autoimmunity, with an interplay between genetic susceptibility and environment. Several neurologic demyelinating diseases have been reported following vaccination, notably Guillain-Barre syndrome (GBS) and acute disseminated encephalomyelitis (ADEM) (an inflammatory disease of the central nervous system). A number of the most common vaccines appear to have some involvement with autoimmunity.
Human Papilloma Virus Vaccine and Primary Ovarian Failure: Another Facet of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants
SYNOPSIS
Israeli, Italian, and Canadian researchers tie HPV vaccine to primary ovarian failure.
CITATION
Selena Colafrancesco, Carlo Perricone, Lucija Tomljenovic, Yehuda Shoenfeld. American Journal of Reproductive Immunology, 2013.
SUMMARY
“We documented here the evidence of the potential of the HPV vaccine to trigger a life-disabling autoimmune condition. The increasing number of similar reports of post HPV vaccine-linked autoimmunity and the uncertainty of long-term clinical benefits of HPV vaccination are a matter of public health that warrants further rigorous inquiry.”
Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum
SYNOPSIS
Scientists from Mexico and Israel explain adjuvants (aluminum) used in vaccines can induce autoimmunity.
CITATION
Vera-Lastra O, Medina G, Del-Pilar Cruz Dominguez M, Jara LJ. Expert Reviews-Clinical Immunology. 2013;9(4):361-373.
SUMMARY
Activation of the immune system by adjuvants could trigger manifestations of autoimmunity or autoimmune disease. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) includes postvaccination phenomena, macrophagic myofasciitis (MMF), Gulf War syndrome and siliconosis. Various adjuvants used in vaccines enhance a specific immune response against antigens and may produce autoimmunity and autoimmune disease in experimental models and humans. “The clinical and laboratory data support an association between adjuvants and autoimmune diseases.”