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Science Library Abstract
Published: 2015
SYNOPSIS

Evidence points to vaccine-induced autoimmunity and adjuvant-induced autoimmunity in experimental models and human patients.

TITLE

Vaccines, adjuvants and autoimmunity

CITATION

Guimarães LE, Baker B, Perricone C, Shoenfeld Y. Pharmacological Research. 2015;100:190-209.

SUMMARY

This review of the literature assembles evidence of vaccine-induced autoimmunity and adjuvant-induced autoimmunity in both experimental models as well as human patients. Adjuvants and infectious agents may exert their immune-enhancing effects through various functional activities, encompassed by the adjuvant effect. These mechanisms are shared by different conditions triggered by adjuvants leading to the autoimmune/inflammatory syndrome induced by adjuvants (ASIA).

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