Science Library Abstract
Published: 2018
SYNOPSIS

The evidence does not support HPV vaccine effectiveness in women in their mid- to late 20s.

TITLE

Effectiveness of catch-up human papillomavirus vaccination on incident cervical neoplasia in a US health-care setting: a population-based case-control study

CITATION

Silverberg MJ, Leyden WA, O’Lam J, et al. Effectiveness of catch-up human papillomavirus vaccination on incident cervical neoplasia in a US health-care setting: a population-based case-control study. Lancet Child and Adolescent Health. 2018;2(10):707-714.

SUMMARY

This article reports limited effectiveness of “catch-up” HPV vaccination in women in their 20s. The vaccine showed “no significant effectiveness” in women who initiated vaccination between 21-26 years of age (or who received less than the three-dose series), in line with other studies that likewise have found no evidence of “any vaccine effectiveness” in women in their mid- to late 20s. [Note: Although the study’s results “conflict” with arguments to extend HPV vaccination to women of older ages, the FDA nontheless approved Gardasil-9 for women and men between ages 27 and 45 in October 2018.]

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