SYNOPSIS
These data provide a plausible explanation for pertussis resurgence and suggest that attaining herd immunity will require the development of improved vaccination strategies that prevent B. pertussis colonization and transmission.
TITLE
Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model
CITATION
Jason M. Warfel, Lindsey I. Zimmerman, and Tod J. Merkel; Proceedings of the National Academy of Sciences; January 14, 2014, 111 (2), 787-792; https://doi.org/10.1073/pnas.1314688110.
SUMMARY
In this study, researchers found that current acellular pertussis (aP) vaccines fail to prevent colonization and transmission. Nonhuman primates vaccinated with current acellular Pertussis (aP) were protected from severe symptoms but not infection and readily transmitted Bordetella pertussis to contacts.