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Glyphosate (Round-Up)
SYNOPSIS
D. Kubsad, E. Nilsson, S. King, I. Sadler-Riggleman, D. Beck, M. Skinner Ancestral environmental exposures to a variety of factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. One of the most widely used agricultural pesticides worldwide is the herbicide glyphosate (N-(phosphonomethyl)glycine), commonly known as Roundup. There are […]
TITLE
Assessment of Glyphosate Induced Epigenetic Transgenerational Inheritance of Pathologies and Sperm Epimutations: Generational Toxicology
D. Kubsad, E. Nilsson, S. King, I. Sadler-Riggleman, D. Beck, M. Skinner
Ancestral environmental exposures to a variety of factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. One of the most widely used agricultural pesticides worldwide is the herbicide glyphosate (N-(phosphonomethyl)glycine), commonly known as Roundup. There are an increasing number of conflicting reports regarding the direct exposure toxicity (risk) of glyphosate, but no rigorous investigations on the generational actions. The current study using a transient exposure of gestating F0 generation female rats found negligible impacts of glyphosate on the directly exposed F0 generation, or F1 generation offspring pathology. In contrast, dramatic increases in pathologies in the F2 generation grand-offspring, and F3 transgenerational great-grand-offspring were observed. The transgenerational pathologies observed include prostate disease, obesity, kidney disease, ovarian disease, and parturition (birth) abnormalities. Epigenetic analysis of the F1, F2 and F3 generation sperm identified differential DNA methylation regions (DMRs). A number of DMR associated genes were identified and previously shown to be involved in pathologies. Therefore, we propose glyphosate can induce the transgenerational inheritance of disease and germline (e.g. sperm) epimutations. Observations suggest the generational toxicology of glyphosate needs to be considered in the disease etiology of future generations.
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SYNOPSIS
These results highlight a relationship between environmental and residential exposure to glyphosate and high prevalence of asthma, while experimental studies support the biological plausibility of this association.
TITLE
Risk of asthma and environmental exposure to glyphosate in an ecological study.
CITATION
Medardo Avila-Vázquez, Flavia Difilippo, Bryan Mac Lean, et al. Risk of asthma and environmental exposure to glyphosate in an ecological study. Authorea. August 13, 2020.
DOI: 10.22541/au.159734524.47178780
SUMMARY
Background: There is strong evidence of the link between asthma and occupational exposure to pesticides and glyphosate in agricultural workers, but it is limited on environmental or residential exposure to these chemicals. Methods: We analyze asthma prevalence in an agricultural town with high use of pesticides, mainly glyphosate with an ecological study conducted in Monte Maíz, Argentina, composed of a chemical and environmental analysis to determine the burden of exposure to glyphosate and pesticides in general, and a cross-sectional asthma study that uses the methodological criteria of the International Study of Asthma and Allergies in Childhood (ISAAC); the prevalence’s found in Monte Maíz are compared with the results of ISAAC in Argentine cities with low exposure to pesticides. Results: In Monte Maíz high and preponderant levels of glyphosate were found in the soil and in corn husk and soybean powder. The environmental exposure burden to pesticides was 121 kilos, for glyphosate 81 kilos per person per year, while this burden in the entire country is 7.9 and 6 kilos respectively. The found asthma prevalences were several times higher than those of reference in all ages, the risk of asthma in children of 13 and 14 years old, with respect to those of three large Argentine cities is: OR of 4.64 (CI: 3, 26 – 6.60). Conclusion: These results highlight a relationship between environmental and residential exposure to glyphosate and high prevalence of asthma, while experimental studies support the biological plausibility of this association.
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SYNOPSIS
Roundup, glyphosate and glyphosate metabolites damage DNA in human blood cells, and Roundup has the strongest effects.
TITLE
The mechanism of DNA damage induced by Roundup 360 PLUS, glyphosate and AMPA in human peripheral blood mononuclear cells—genotoxic risk assessement [sic]
Citation
Wozniak E, Sicinska P, Michalowicz J, et al. The mechanism of DNA damage induced by Roundup 360 PLUS, glyphosate and AMPA in human peripheral blood mononuclear cells—genotoxic risk assessement [sic]. Food and Chemical Toxicology. 2018;120:510-522.
Summary
A study assessing the effects of Roundup, glyphosate and a glyphosate metabolite found that all three damaged DNA in human blood cells, with Roundup having the strongest effects, even at very low concentrations.