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Vaccine Failure
Do vaccines increase or decrease susceptibility to diseases other than those they protect against?
SYNOPSIS
Contrary to the long-held belief that the effects of vaccines are specific for the disease they were created; compelling evidence has demonstrated that vaccines can exert positive or deleterious non-specific effects (NSEs).
A. Rubio-Casillas, C. Manuel Rodriguez-Quintero, E. M. Redwan, M. Nath Gupta, V. N. Uversky, M. Raszek
Contrary to the long-held belief that the effects of vaccines are specific for the disease they were created; compelling evidence has demonstrated that vaccines can exert positive or deleterious non-specific effects (NSEs). In this review, we compiled research reports from the last 40 years, which were found based on the PubMed search for the epidemiological and immunological studies on the non-specific effects (NSEs) of the most common human vaccines. Analysis of information showed that live vaccines induce positive NSEs, whereas non-live vaccines induce several negative NSEs, including increased female mortality associated with enhanced susceptibility to other infectious diseases, especially in developing countries. These negative NSEs are determined by the vaccination sequence, the antigen concentration in vaccines, the type of vaccine used (live vs. non-live), and also by repeated vaccination. We do not recommend stopping using non-live vaccines, as they have demonstrated to protect against their target disease, so the suggestion is that their detrimental NSEs can be minimized simply by changing the current vaccination sequence. High IgG4 antibody levels generated in response to repeated inoculation with mRNA COVID-19 vaccines could be associated with a higher mortality rate from unrelated diseases and infections by suppressing the immune system. Since most COVID-19 vaccinated countries are reporting high percentages of excess mortality not directly attributable to deaths from such disease, the NSEs of mRNA vaccines on overall mortality should be studied in depth.
Inter-pathogen peptide sharing and the original antigenic sin: solving a paradox
SYNOPSIS
The peptides in vaccine pathogens and in human proteins overlap, creating a risk of post-vaccination cross-reactivity that can explain vaccine failure and vaccine-associated adverse events.
Citation
Kanduc D, Schoenfeld Y. Inter-pathogen peptide sharing and the original antigenic sin: solving a paradox. The Open Immunology Journal. 2018;8:16-27.
Summary
The authors explain how the overlap between peptides present in vaccine pathogens and in human proteins creates a risk of cross-reactivity following vaccination. Cross-reactivity can explain not only vaccine failure but also vaccine-associated adverse events, including autoimmunity. The “massive microbial vs human peptide overlap” suggests that vaccines cannot be safe and effective unless they are based on peptide sequences that are “uniquely owned by the infectious agent” but absent from the full set of human proteins.
Repeated influenza vaccination of healthy children and adults: borrow now, pay later?
SYNOPSIS
Repeated influenza vaccination at a young age substantially increases the risk of influenza at older ages.
CITATION
Carrat F, Lavenu A, Cauchemez S, Deleger S. Repeated influenza vaccination of healthy children and adults: borrow now, pay later? Epidemiology & Infection 2006;134(1):63-70.
SUMMARY
This study shows that repeated influenza vaccination at younger ages may double the risk of influenza in the elderly. The study suggests that the “possible benefits of vaccinating children after 5 years of age, and otherwise healthy adults—particularly over a long period and mainly for economic reasons—could be outweighed by severe clinical consequences and increased costs in the elderly.” Moreover, the findings are “solely due to differences between vaccine-induced immunity and naturally acquired immunity.” Unlike vaccination, naturally acquired immunity can provide long-lasting protection against subsequent infection by the same viral subtype.