Synergistic Toxicity
Immunoexcitotoxicity as the central mechanism of etiopathology and treatment of autism spectrum disorders: a possible role of fluoride and aluminum
SYNOPSIS
Fluoride and aluminum, alone or in combination, can produce the condition of “immunoexcitotoxicity” that leads to the pathological changes seen in autism.
Citation
Strunecka A, Blaylock RL, Patocka J, Strunecky O. Surgical Neurology International. 2018;9:74.
Summary
Children experience sequential immune stimulation from a growing number of neurotoxic metals and chemicals, vaccines and persistent viral infections. This excessive immune activation is the “initiating and sustaining event” in autism spectrum disorder (ASD), triggering inflammation and a cascade of excitotoxicity (damaged nerve cells). The fluoride added to drinking water and the aluminum in vaccines—singly or synergistically as aluminofluoride—can be potent factors in producing the condition of “immunoexcitotoxicity” that leads to the pathological changes seen in ASD.
Synergistic effects of heavy metals and pesticides in living systems
SYNOPSIS
Combined exposure to heavy metals and pesticides can lead to more severe effects on human health compared to their individual effects.
Citation
Singh N, Gupta VK, Kumar A, Sharma B. Synergistic effects of heavy metals and pesticides in living systems. Frontiers in Chemistry. 2017;5:70.
Summary
Combined exposure to heavy metals and pesticides can lead to more severe effects on human health compared to their individual effects. This review reports that various combinations (pesticides combined with pesticides, pesticides combined with heavy metals, and heavy metals combined with heavy metals) all act synergistically and exhibit more toxicity than a single toxin alone. More work is needed to study the biotransformation of heavy metals and pesticides in combination and the mechanisms by which they affect toxicity.