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Macrophagic Myofasciitis-MMF

Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system
Published: 2019
SYNOPSIS

We present epidemiological, clinical and experimental evidence that Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) constitutes a major type of adverse effect of vaccines, especially those containing poorly degradable particulate aluminum adjuvants.

CITATION

Romain K. Gherardi, Guillemette Crepeaux, Francois-Jerome Authier; Autoimmunity Reviews, Volume 18, Issue 7, July 2019, Pages 691-705.

SUMMARY

Evidence showed Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) constitutes a major type of adverse effect of vaccines, especially those containing poorly degradable particulate aluminum adjuvants. It was supported by an epidemiological study comparing vaccinated vs unvaccinated militaries and revealed affected patients suffer from cognitive dysfunction affecting attention, memory and inter-hemispheric connexions, well correlated to brain perfusion defects and associated with a stereotyped and distinctive pattern of cerebral glucose hypometabolism. Instead of being rapidly solubilized in the extracellular space, injected aluminum particles are quickly captured by immune cells and transported to distant organs and the brain where they elicit an inflammatory response and exert selective low dose long-term neurotoxicity.

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Macrophagic myofasciitis lesions assess long-term persistence of vaccine derived aluminum hydroxide in muscle
Published: 2001
SYNOPSIS

French scientists tie aluminum adjuvant in vaccine to macrophagic myofasciitis.

CITATION

R.K. Gherardi, M. Coquet, P. Cherin, L. Belec, P. Moretto, P.A. Dreyfus. Brain, 2001, 124, 1821-1831.

SUMMARY

“Macrophagic myofasciitis (MMF) is an emerging condition of unknown cause, detected in patients with diffuse arthromyalgias and fatigue, and characterized by muscle infiltration by granular periodic acid-Schiff’s reagent-positive macrophages and lymphocytes. Intracytoplasmic inclusions have been observed in macrophages of some patients. To assess their significance, electron microscopy was performed in 40 consecutive cases and chemical analysis was done by microanalysis and atomic absorption spectrometry. Inclusions were constantly detected and corresponded to aluminium hydroxide, an immunostimulatory compound frequently used as a vaccine adjuvant.”

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