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Mercury-induced autoimmunity: Drifting from micro to macro concerns on autoimmune disorders
Published: 2020
SYNOPSIS

In susceptible individuals, chronic low Hg exposure may trigger local and systemic inflammation, even exacerbating the already existing autoimmune response in patients with autoimmunity.

CITATION

Bjorklund, G., M. Peana, M. Dadar, S. Chirumbolo, J. Aaseth, and N. Martins. 2020. ‘Mercury-induced autoimmunity: Drifting from micro to macro concerns on autoimmune disorders’, Clin Immunol: 108352.

SUMMARY

Mercury (Hg) is widely recognized as a neurotoxic metal, besides it can also act as a proinflammatory agent and immunostimulant, depending on individual exposure and susceptibility. Mercury exposure may arise from internal body pathways, such as via dental amalgams, preservatives in drugs and vaccines, and seafood consumption, or even from external pathways, i.e., occupation, environmental pollution, and handling of metallic items and cosmetics containing Hg. In susceptible individuals, chronic low Hg exposure may trigger local and systemic inflammation, even exacerbating the already existing autoimmune response in patients with autoimmunity. Mercury exposure can trigger dysfunction of the autoimmune responses and aggravate immunotoxic effects associated with elevated serum autoantibodies titers. The purpose of the present report is to provide a critical overview of the many issues associated with Hg exposure and autoimmunity. In addition, the paper also focuses on individual susceptibility and other health effects of Hg.

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Vaccines and autoimmune diseases of the adult
Published: 2010
SYNOPSIS

It is feasible that vaccinations may contribute to the mosaic of autoimmunity.

CITATION

Orbach H, Agmon-Levin N, Zandman-Goddard G. Discovery Medicine. 2014;10(2):101-107.

SUMMARY

Infectious agents contribute to the environmental factors involved in the development of autoimmune diseases possibly through molecular mimicry mechanisms. Hence, it is feasible that vaccinations may also contribute to the mosaic of autoimmunity. Evidence for the association of vaccinations and the development of these diseases is presented in this review.

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