Intensive Care Unit - ICU
Nutrients, Low 25-Hydroxyvitamin D Levels on Admission to the Intensive Care Unit May Predispose COVID-19 Pneumonia Patients to a Higher 28-Day Mortality Risk: A Pilot Study on a Greek ICU Cohort.
SYNOPSIS
Observational study showing improved immune system activity if supplementation was given to Vit D insufficient and deficient patients.
CITATION
Vassiliou AG, Jahaj E, Pratikaki M, Orfanos SE, Dimopoulou I, Kotanidou A. Low 25-Hydroxyvitamin D Levels on Admission to the Intensive Care Unit May Predispose COVID-19 Pneumonia Patients to a Higher 28-Day Mortality Risk: A Pilot Study on a Greek ICU Cohort. Nutrients. 2020 Dec 9;12(12):3773. doi: 10.3390/nu12123773. PMID: 33316914; PMCID: PMC7764169.
SUMMARY
We aimed to examine whether low intensive care unit (ICU) admission vitamin D levels are associated with worse outcomes of COVID-19 pneumonia. This was a prospective observational study of SARS-CoV2 positive critically ill patients treated in a multidisciplinary ICU. Thirty (30) Greek patients were included, in whom vitamin D level was measured on ICU admission. Eighty (80%) percent of patients had vitamin D deficiency, and the remaining insufficiency. All patients who died within 28 days belonged to the low vitamin D group. Survival analysis showed that the low vitamin D group had a higher 28-day survival absence probability. Critically ill COVID-19 patients who died in the ICU within 28 days appeared to have lower ICU admission vitamin D levels compared to survivors. It seems plausible, therefore, that low vitamin D levels may predispose COVID-19 patients to an increased 28-day mortality risk.
High dose vitamin D improves total serum antioxidant capacity and ICU outcome in critically ill patients – A randomized, double-blind clinical trial.
SYNOPSIS
Administration of vitamin D may increase TAC levels and decrease the length of stay and duration of mechanical ventilation in ICU patients.
CITATION
Mohammad Sistanizad, Mehran Kouchek, Mohammad Miri, Sara Salarian, Seyedpouzhia Shojaei, Fatemeh Moeini Vasegh, Hossein Seifi Kafshgari, Roja Qobadighadikolaei. High dose vitamin D improves total serum antioxidant capacity and ICU outcome in critically ill patients – A randomized, double-blind clinical trial. European Journal of Integrative Medicine, Volume 42, 2021,101271, ISSN 1876-3820, https://doi.org/10.1016/j.eujim.2020.101271.
SUMMARY
The results show that injection of vitamin D leads to a significant increase in the mean changes of vitamin D level on the seventh day of the study and Total Antioxidant Capacity (TAC) levels. ICU length of stay was lessened. Twelve patients in the placebo group and 5 in the vitamin D group died within the 28 day study period. The duration of mechanical ventilation was lessened in vitamin D and placebo arms. Authors do not indicate why the patients were hospitalized or if any of the patients were COVID-19 patients.