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Genotoxicity

Selective accumulation of aluminum in cerebral arteries in Alzheimer’s disease (AD)
Published: 2013
SYNOPSIS

Researchers found higher accumulations of aluminum in the brains of patients with Alzheimer’s disease.

CITATION

Bhattacharjee S, Zhao Y, Hill JM, … Lukiw WJ. Journal of Inorganic Biochemistry. 2013;126:35–37.

SUMMARY

To improve understanding of a pathological aluminum entry system into the brain, this study examined the aluminum content of eight arteries that supply blood to the hippocampus, including the aorta and several cerebral arteries. In contrast to age-matched controls, AD patients exhibited a gradient of increasing aluminum concentration from the aorta to the posterior cerebral artery that supplies blood to the hippocampus.

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