Science Library Category:

Genotype-Environment Interaction

Genetic susceptibility may modify the association between cell phone use and thyroid cancer: A population-based case-control study in Connecticut
Published: 2020

When some genetic variants were present, cell phone use was significantly associated with thyroid cancer.


Jiajun Luo, Hang Li, Nicole C. Deziel, Huang Huang, Nan Zhao, Shuangge Ma, Xin Ni, Robert Udelsman, Yawei Zhang. Environmental Research; Volume 182, March 2020, 109013.


Emerging studies have provided evidence on the carcinogenicity of radiofrequency radiation (RFR) from cell phones. This study aims to test the genetic susceptibility on the association between cell phone use and thyroid cancer. Population-based case-control study was conducted in Connecticut between 2010 and 2011 including 440 thyroid cancer cases and 465 population-based controls with genotyping information for 823 single nucleotide polymorphisms (SNPs) in 176 DNA genes. We used multivariate unconditional logistic regression models to estimate the genotype-environment interaction between each SNP and cell phone use and to estimate the association with cell phone use in populations according to SNP variants. Our result suggests that genetic susceptibilities modify the associations between cell phone use and risk of thyroid cancer. The findings provide more evidence for RFR carcinogenic group classification.

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