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Asthma
Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan
SYNOPSIS
The prevalence of asthma, wheeze and eczema among children at 12 months of age might be related to the amount of inactivated vaccine exposure before 6 months of age.
CITATION
Yamamoto-Hanada et al. Environmental Health and Preventive Medicine (2020) 25:27
https://doi.org/10.1186/s12199-020-00864-7
SUMMARY
Adjuvants used in inactivated vaccines often upregulate type 2 immunity, which is dominant in allergic diseases. The authors hypothesised that cumulative adjuvant exposure in infancy may influence the development of allergies later in life by changing the balance of type 1/type 2 immunity and examined the relationship between immunisation with different vaccine types and later allergic disease development. They found that physician-diagnosed asthma was associated with receiving three or four to five different inactivated vaccines, compared with children who received only one inactivated vaccine. Similar results were found for two questionnaire-based symptoms, i.e. wheeze (three vaccines vs. a single vaccine) and
eczema (four or five vaccines vs. a single vaccine).
Parental asthma and risk of autism spectrum disorder in offspring: a population and family-based case-control study
SYNOPSIS
Children of mothers with asthma are at increased risk of developing autism, highlighting the importance of studying environmental risk factors during pregnancy.
Citation
Gong T, Lundholm C, Rejno G, et al. Clinical and Experimental Allergy. 2019 Feb 11.
Summary
This large observational study reports that children of mothers with asthma are at increased risk of developing autism spectrum disorder (ASD). The study looked at all children born in Sweden between 1992 and 2007, including almost 23,000 children with ASD. The researchers posit that maternal immune activation during pregnancy may represent a biological mechanism explaining the association. The increased ASD risk could not be explained by socioeconomic, demographic, or genetic factors, underscoring “the importance of investigating other maternal environmental factors.”
Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma?
SYNOPSIS
Children who delayed the timing of the DPT vaccine had lower rates of asthma.
CITATION
McDonald KL, Huq SI. Journal of the American Academy of Allergy, Asthma and Immunology. 2008;121:626-631.
SUMMARY
“Early childhood immunizations have been viewed as promoters of asthma development by stimulating a T(H)2-type immune response or decreasing microbial pressure, which shifts the balance between T(H)1 and T(H)2 immunity. Among 11, 531 children who received at least 4 doses of DPT, the risk of asthma was reduced to (1/2) in children whose first dose of DPT was delayed by more than 2 months.”
Effects of Diphtheria-Tetanus-Pertussis or Tetanus Vaccination on Allergies and Allergy-Related Respiratory Symptoms Among Children and Adolescents in the United States
SYNOPSIS
UCLA researchers find the DTP vaccine is causing asthma.
CITATION
Eric L. Hurwitz, DC, PhD, and Hal Morgenstern, PhD. Journal of Manipulative and Physiological Therapeutics, Volume 23, Number 2, February 2000.
SUMMARY
“Asthma and other allergic hypersensitivity reactions and related symptoms may be caused, in part, by the delayed effects of DTP or tetanus vaccination. Because the proportion of US children who have received at least 1 dose of DTP vaccine approaches 100%, the number of allergies and allergy-related conditions attributable to DTP or tetanus vaccination in the United States may be very high. For example, assuming that the estimated vaccination effect is unbiased, 50% of diagnosed asthma cases (2.93 million) in US children and adolescents would be prevented if the DTP or tetanus vaccination was not administered.”