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Science Library Abstract
Published: 2005
SYNOPSIS

Vaccine mercury depletes a vital antioxidant, glutathione.

TITLE

Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors

CITATION

S.J. James, William Slikker, Stepan Melnyk, Elizabeth New,
Marta Pogribna, Stefanie Jernigan. NeuroToxicology, 26 (2005) 1–8.

SUMMARY

“Thimerosal is an antiseptic containing 49.5% ethyl mercury that has been used for years as a preservative in many infant vaccines and in flu vaccines. Environmental methyl mercury has been shown to be highly neurotoxic, especially to the developing brain. Because mercury has a high affinity for thiol (sulfhydryl (-SH)) groups, the thiol-containing antioxidant, glutathione (GSH), provides the major intracellular defense against mercury-induced neurotoxicity. Cultured neuroblastoma cells were found to have lower levels of GSH and increased sensitivity to thimerosal toxicity compared to glioblastoma cells that have higher basal levels of intracellular GSH. Thimerosal-induced cytotoxicity was associated with depletion of intracellular GSH in both cell lines. Although Thimerosal has been recently removed from most children’s vaccines, it is still present in flu vaccines given to pregnant women, the elderly, and to children in developing countries.”

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