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SYNOPSIS
The specific mechanism of action of each vaccine adjuvant may have different effects on the course of autoimmune conditions resulting from vaccination.
TITLE
On vaccine’s adjuvants and autoimmunity: Current evidence and future perspectives
CITATION
Pellegrino P, Clementi E, Radice S. Autoimmunity Reviews. 2015;14(10):880-888.
SUMMARY
Adjuvants in vaccines have been implicated in “Autoimmune/inflammatory Syndrome Induced by Adjuvants” (ASIA), an umbrella of clinical conditions that includes post-vaccination adverse reactions. Aluminum-based compounds, in particular, are associated with the development of vaccine adjuvant-induced autoimmune diseases, but vaccines with other adjuvants may also cause specific autoimmune adverse reactions via different pathogenic mechanisms. The specific mechanism of action of each single adjuvant may have different effects on the course of different diseases.