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SYNOPSIS
Administration of vitamin D may increase TAC levels and decrease the length of stay and duration of mechanical ventilation in ICU patients.
TITLE
High dose vitamin D improves total serum antioxidant capacity and ICU outcome in critically ill patients – A randomized, double-blind clinical trial.
CITATION
Mohammad Sistanizad, Mehran Kouchek, Mohammad Miri, Sara Salarian, Seyedpouzhia Shojaei, Fatemeh Moeini Vasegh, Hossein Seifi Kafshgari, Roja Qobadighadikolaei. High dose vitamin D improves total serum antioxidant capacity and ICU outcome in critically ill patients – A randomized, double-blind clinical trial. European Journal of Integrative Medicine, Volume 42, 2021,101271, ISSN 1876-3820, https://doi.org/10.1016/j.eujim.2020.101271.
SUMMARY
The results show that injection of vitamin D leads to a significant increase in the mean changes of vitamin D level on the seventh day of the study and Total Antioxidant Capacity (TAC) levels. ICU length of stay was lessened. Twelve patients in the placebo group and 5 in the vitamin D group died within the 28 day study period. The duration of mechanical ventilation was lessened in vitamin D and placebo arms. Authors do not indicate why the patients were hospitalized or if any of the patients were COVID-19 patients.