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Tdap

Interacting, Nonspecific, Immunological Effects of Bacille Calmette-Guérin and Tetanus-diphtheria-pertussis Inactivated Polio Vaccinations: An Explorative, Randomized Trial
Published: 2020
SYNOPSIS

The data indicated non-live vaccines like Tdap are immunosuppressive. It could mean each non-live vaccine administered could defeat the benefits of all previously administered vaccines. And of course, the general immunosuppressive effect means the person is more susceptible to all pathogens except the ones the vaccine is intended to protect.

CITATION
Blok BA, de Bree LCJ, Diavatopoulos DA, Langereis JD, Joosten LAB, Aaby P, van Crevel R, Benn CS, Netea MG. Interacting, Nonspecific, Immunological Effects of Bacille Calmette-Guérin and Tetanus-diphtheria-pertussis Inactivated Polio Vaccinations: An Explorative, Randomized Trial. Clin Infect Dis. 2020 Jan 16;70(3):455-463. doi: 10.1093/cid/ciz246. PMID: 30919883.
SUMMARY

Certain vaccines, such as Bacille Calmette-Guérin (BCG), have nonspecific effects, which modulate innate immune responses and lead to protection against mortality from unrelated infections (trained immunity). In contrast, in spite of the disease-specific effects, an enhanced overall mortality has been described after diphtheria-tetanus-pertussis (DTP) vaccination in females. This randomized trial aimed to investigate the nonspecific immunological effects of BCG and DTP-containing vaccines on the immune response to unrelated pathogens. The trial results showed Tdap vaccination led to short-term potentiation and long-term repression of monocyte-derived cytokine responses, and short-term as well as long-term repression of T-cell reactivity to unrelated pathogens. BCG led to short-term and long-term potentiation of monocyte-derived cytokine responses. When given together with Tdap or after Tdap, BCG abrogated the immunosuppressive effects of Tdap vaccination.

The data indicated non-live vaccines like Tdap are immunosuppressive. It could mean each non-live vaccine administered could defeat the benefits of all previously administered vaccines. And of course, the general immunosuppressive effect means the person is more susceptible to all pathogens except the ones the vaccine is intended to protect.

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