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Diphtheria-Tetanus-Acellular-Pertussis Vaccines-DTaP

The 112-Year Odyssey of Pertussis and Pertussis Vaccines—Mistakes Made and Implications for the Future
Published: 2019
SYNOPSIS

Because of linked-epitope suppression, all children who were primed by DTaP vaccines will be more susceptible to pertussis throughout their lifetimes, and there is no easy way to decrease this increased lifetime susceptibility.

CITATION

Cherry, James D. , Journal of the Pediatric Infectious Diseases Society, piz005, 2019 Feb 22.

SUMMARY

In the last 13 years, major pertussis epidemics have occurred in the United States, and numerous studies have shown the deficiencies of DTaP vaccines, including the small number of antigens that the vaccines contain and the type of cellular immune response that they elicit. The type of cellular response a predominantly, T2 response results in less efficacy and shorter duration of protection. Because of the small number of antigens (3–5 in DTaP vaccines vs >3000 in DTwP vaccines), linked-epitope suppression occurs. Because of linked-epitope suppression, all children who were primed by DTaP vaccines will be more susceptible to pertussis throughout their lifetimes, and there is no easy way to decrease this increased lifetime susceptibility.

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Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus, Acellular Pertussis, Inactivated Poliovirus, and Haemophilus Influenzae Type b
Published: 2012
SYNOPSIS

Danish researchers found children 8-times more likely to have a febrile seizure on the day of vaccination of DTaP-IPV-HiB vaccine.

CITATION

Yuelian Sun, Jakob Christensen, Anders Hviid, Jiong Li, Et al. Journal of the Amercian Medical Association, February 22/29, 2012—Vol 307, No. 8.

SUMMARY

“DTaP-IPV-Hib vaccination was associated with an increased risk of febrile seizures on the day of the first 2 vaccinations given at 3 and 5 months.”

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Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma?
Published: 2008
SYNOPSIS

Children who delayed the timing of the DPT vaccine had lower rates of asthma.

CITATION

McDonald KL, Huq SI. Journal of the American Academy of Allergy, Asthma and Immunology. 2008;121:626-631.

SUMMARY

“Early childhood immunizations have been viewed as promoters of asthma development by stimulating a T(H)2-type immune response or decreasing microbial pressure, which shifts the balance between T(H)1 and T(H)2 immunity. Among 11, 531 children who received at least 4 doses of DPT, the risk of asthma was reduced to (1/2) in children whose first dose of DPT was delayed by more than 2 months.”

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