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Autoantibody

Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil
Published: 2016
SYNOPSIS

Israeli, Canadian and Colombian scientists show that the Gardasil vaccine triggers brain inflammation and autoimmunity in mice.

CITATION

Inbar R, Weiss R, Tomljenovic L, Arango M-T, Deri Y, Shaw CA, Chapman J, Blank M, Shoenfeld Y. Immunologic Research. 2017;65(1):136-149.

SUMMARY

“Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine trials utilize aluminum (Al) adjuvants as placebos despite much evidence showing that Al in vaccine-relevant exposures can be toxic to humans and animals…. It appears that Gardasil via its Al adjuvant and HPV antigens has the ability to trigger neuroinflammation and autoimmune reactions, further leading to behavioral changes…. In light of these findings, this study highlights the necessity of proceeding with caution with respect to further mass-immunization practices with a vaccine of yet unproven long-term clinical benefit in cervical cancer prevention.”

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Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects
Published: 2013
SYNOPSIS

Israeli and Italian researchers demonstrate that exposure to aluminum in vaccines can lead to autoimmune and brain dysfunction.

CITATION

Perricone C, Colafrancesco S, Mazor RD, Soriano A, Agmon-Levin N, Shoenfeld Y. Journal of Autoimmunity. 2013;47:1-16.

SUMMARY

Environmental factors play a critical role in the induction of autoimmunity, with an interplay between genetic susceptibility and environment. Several neurologic demyelinating diseases have been reported following vaccination, notably Guillain-Barre syndrome (GBS) and acute disseminated encephalomyelitis (ADEM) (an inflammatory disease of the central nervous system). A number of the most common vaccines appear to have some involvement with autoimmunity.

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Human Papilloma Virus Vaccine and Primary Ovarian Failure: Another Facet of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants
Published: 2013
SYNOPSIS

Israeli, Italian, and Canadian researchers tie HPV vaccine to primary ovarian failure.

CITATION

Selena Colafrancesco, Carlo Perricone, Lucija Tomljenovic, Yehuda Shoenfeld. American Journal of Reproductive Immunology, 2013.

SUMMARY

“We documented here the evidence of the potential of the HPV vaccine to trigger a life-disabling autoimmune condition. The increasing number of similar reports of post HPV vaccine-linked autoimmunity and the uncertainty of long-term clinical benefits of HPV vaccination are a matter of public health that warrants further rigorous inquiry.”

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Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism
Published: 2002
SYNOPSIS

Utah state scientists find autoimmune reaction to MMR in children with autism, including autoimmunity to myelin basic protein, a brain building-block.

CITATION

Singh VK, Lin SX, Newell E, Nelson C. Journal of Biomedical Science. 2002;9:359–364.

SUMMARY

“[A]s described herein, autistic children showed a serological correlation between MMR and brain autoimmunity, i.e., over 90% of MMR antibody-positive autistic sera also had autoantibodies to brain MBP. This is quite an intriguing observation in favor of a connection between atypical measles infection and autism; an atypical infection usually refers to infection that occurs in the absence of a rash. An atypical measles infection in the absence of a rash and unusual neurological symptoms was recently described to suggest the existence of a variant MV in children and adults. In light of these new findings, we suggest that a considerable proportion of autistic cases may result from an atypical measles infection that does not produce a rash but causes neurological symptoms in some children. The source of this virus could be a variant MV or it could be the MMR vaccine.”