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Science Library Abstract
Published: 2021
SYNOPSIS

The Yuan Lab has developed Gn pig models representing HGM as healthy (HHGM) and unhealthy (UHGM). They found that vaccinated UHMG pigs had higher viral shedding titres and more severe clinical signs compared to HHGM pigs after virulent HRV challenge. In another study, they found that Lactobacillus partially prevented intestinal injury caused by HRV, ameliorating rotavirus diarrhea. Such studies clearly demonstrate the protective nature of commensal flora and that differences in immune responses and clinical disease are due to the influence of microbial differences.

TITLE

Corrigendum to “Acute exposure and chronic retention of aluminum in three vaccine schedules and effects of genetic and environmental variation”

CITATION

Grant McFarland, Elaine La Joie, Paul Thomas, James Lyons-Weiler, Corrigendum to “Acute exposure and chronic retention of aluminum in three vaccine schedules and effects of genetic and environmental variation”. [J. Trace Elem. Med. Biol. 58 (2020) 126444], Journal of Trace Elements in Medicine and Biology, Volume 65, 2021, 126727, ISSN 0946-672X, https://doi.org/10.1016/j.jtemb.2021.126727.

SUMMARY

The Yuan Lab has developed Gn pig models representing HGM as healthy (HHGM) and unhealthy (UHGM). They found that vaccinated UHMG pigs had higher viral shedding titres and more severe clinical signs compared to HHGM pigs after virulent HRV challenge. In another study, they found that Lactobacillus partially prevented intestinal injury caused by HRV, ameliorating rotavirus diarrhea. Such studies clearly demonstrate the protective nature of commensal flora and that differences in immune responses and clinical disease are due to the influence of microbial differences.

There is potential for future research using Gn pigs to test childhood vaccines such as Hepatitis B vaccine, currently administered within 12 hours of birth per CDC schedule.

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