Menu
Science Library Abstract
Published: 2020
SYNOPSIS

Quantitative analyses suggest increased brain aluminium content in a number of neurodegenerative diseases including familial Alzheimer’s disease, congophilic amyloid angiopathy, epilepsy and autism.

TITLE

Imaging of aluminium and amyloid β in neurodegenerative disease

CITATION

C. Exley, M.J. Mold; Imaging of aluminium and amyloid β in neurodegenerative disease. Heliyon 6 21 April 2020; https://doi.org/10.1016/j.heliyon.2020.e03839.

SUMMARY

Recent research has confirmed the presence of aluminium in human brain tissue. Quantitative analyses suggest increased brain aluminium content in a number of neurodegenerative diseases including familial Alzheimer’s disease, congophilic amyloid angiopathy, epilepsy and autism. Complementary aluminium-specific fluorescence microscopy identifies the location of aluminium in human brain tissue and demonstrates significant differences in distribution between diseases. Herein we combine these approaches in investigating associations between aluminium in human brain tissue and specific disease-associated neuropathologies.

View Abstract

TAGS