Neurotoxicity
SYNOPSIS
Quantitative analyses suggest increased brain aluminium content in a number of neurodegenerative diseases including familial Alzheimer’s disease, congophilic amyloid angiopathy, epilepsy and autism.
TITLE
Imaging of aluminium and amyloid β in neurodegenerative disease
CITATION
C. Exley, M.J. Mold; Imaging of aluminium and amyloid β in neurodegenerative disease. Heliyon 6 21 April 2020; https://doi.org/10.1016/j.heliyon.2020.e03839.
Recent research has confirmed the presence of aluminium in human brain tissue. Quantitative analyses suggest increased brain aluminium content in a number of neurodegenerative diseases including familial Alzheimer’s disease, congophilic amyloid angiopathy, epilepsy and autism. Complementary aluminium-specific fluorescence microscopy identifies the location of aluminium in human brain tissue and demonstrates significant differences in distribution between diseases. Herein we combine these approaches in investigating associations between aluminium in human brain tissue and specific disease-associated neuropathologies.
TAGS
SYNOPSIS
Aluminum and mercury sulfates may contribute to neurodegeneration and progressive age-related functional decline such as Alzheimer’s disease.
TITLE
Synergism in aluminum and mercury neurotoxicity
CITATION
Alexandrov PN, Pogue AI, Lukiw WJ. Integrative Food, Nutrition and Metabolism. 2018;5(3):1-7. doi: 10.15761/IFNM.1000214.
SUMMARY
The authors analyzed the effects of aluminum and/or mercury, either alone or together, on their ability to induce inflammatory signaling in human cells and in a cell culture that is the same brain cell types targeted by the inflammatory neurodegeneration that characterizes Alzheimer’s disease. They report that neurotoxic metal sulfates obtainable via our environment or diet are significantly potent.
